RESUMO
Complex clinical, functional an laboratory examination of children living under unacceptable risk conditions due to aerogenous exposure to cadmium, chromium, lead and phenol revealed that kidney diseases associated with exposure to metals and phenol develop in children with genetic predisposition to disordered biotransformation of chemicals--polymorphism of genes CYPOX, RCYT 450, SULTA1 in homozygous and heterozygous variants. Increased levels of chemicals in blood causes microcirculation disorders in renal cortex, direct toxic effect in nephrons, suppresses activity of anitoxidant defense on cellular and systemic levels. The authors specified pathogenetically based complex of clinical and laboratory diagnostic markers of chronic kidney diseases associated with exposure to metals (cadmium, chromium, lead) and oxygen-containing (phenol) organic compounds.
Assuntos
Poluentes Atmosféricos/toxicidade , Exposição Ambiental/análise , Glomerulonefrite/diagnóstico , Metais Pesados/toxicidade , Nefrite Intersticial/diagnóstico , Fenol/toxicidade , Adolescente , Poluentes Atmosféricos/sangue , Biomarcadores/análise , Biotransformação/genética , Criança , Pré-Escolar , Exposição Ambiental/efeitos adversos , Glomerulonefrite/induzido quimicamente , Glomerulonefrite/epidemiologia , Glomerulonefrite/genética , Humanos , Indústrias , Metais Pesados/sangue , Nefrite Intersticial/induzido quimicamente , Nefrite Intersticial/epidemiologia , Nefrite Intersticial/genética , Fenol/sangue , Federação RussaRESUMO
There are presented directions of the improvement of strategic approaches to the prevention of respiratory diseases associated with exposure to chemical environmental factors in children. There were substantiated principles of construction of health-preventive technologies, target groups, hygienic and clinical criteria for their formation, volumes and forms of implementation, targeted indices of efficacy.
Assuntos
Poluentes Atmosféricos/efeitos adversos , Exposição Ambiental/efeitos adversos , Guias como Assunto/normas , Substâncias Perigosas/efeitos adversos , Serviços Preventivos de Saúde/organização & administração , Transtornos Respiratórios/prevenção & controle , Criança , Humanos , Transtornos Respiratórios/induzido quimicamenteRESUMO
303 children with the diagnosis "Hepatobiliary disorders of cystic duct or gall bladder" and "Sphincter Oddu's spasm" have been examined. After a profound children's examination, the data of objective survey, and also laboratory, biochemical, immune, functional rates (such as ultrasound survey, cardiointervalography) and findings of chemical-analytical survey of the toxics rate (such as aroma carbons, phenol, aldehydes, aliphatic alcohols) in biospheres of children's organisms were a nalysed. The evaluation of the effectiveness of children's hepatobilliary disorders'treatment in conditions of the environmentae negative factors' influence.