RESUMO
Three new isoprenylated flavones, artoindonesianins G-I (1-3), together with the two known flavones artelastofuran (4) and artelasticin (5), have been isolated from the heartwood of Artocarpus lanceifoliu. The structures of the new compounds were determined on the basis of spectroscopic data. Compounds 1-3 and 5 showed strong cytotoxicity against P-388 cells.
Assuntos
Flavonoides/toxicidade , Moraceae , Fitoterapia , Extratos Vegetais/toxicidade , Flavonoides/química , Humanos , Espectroscopia de Ressonância Magnética , Extratos Vegetais/química , Células Tumorais Cultivadas/efeitos dos fármacosRESUMO
A new stilbene dimer, andalasin A (1), together with the known stilbene oxyresveratrol and the 2-arylbenzofuran glycoside mulberroside C, have been isolated from the wood of Morus macroura. The structure of the new compound was elucidated on the basis of spectroscopic data. Compound 1 shows weak antinematodal and moderate antifungal properties.
Assuntos
Medicamentos de Ervas Chinesas/química , Plantas Medicinais/química , Estilbenos/química , Dimerização , HumanosRESUMO
A new xanthone derivative, artoindonesianin C (1), was isolated from Artocarpus teysmanii, together with two known prenylated flavonoids, cycloartobiloxanthone and artonin J. The structure of artoindonesianin C (1) was determined on the basis of MS and NMR evidence and by comparison with known related compounds.
Assuntos
Flavonoides/isolamento & purificação , Plantas Medicinais/química , Animais , Artemia , Bombyx , Flavonoides/química , Flavonoides/farmacologia , Técnicas In Vitro , Dose Letal Mediana , Leucina/metabolismo , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Microvilosidades/efeitos dos fármacos , Microvilosidades/metabolismo , Epiderme Vegetal/química , Raízes de Plantas/química , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
Two new prenylated flavones, named artoindonesianin A (1) and artoindonesianin B (2), were isolated from the root of Artocarpus champeden, together with a known prenylated flavone, artonin A. The structures of artoindonesianins A and B were determined on the basis of spectral evidence (MS, 1H and 13C NMR) and by comparison with known related compounds. Compounds 1 and 2 exhibited cytotoxic activity against murine leukemia (P-388) cells.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Flavonoides/farmacologia , Plantas Medicinais/química , Animais , Antineoplásicos Fitogênicos/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Flavonoides/isolamento & purificação , Indonésia , Leucemia P388/patologia , Espectroscopia de Ressonância Magnética , Camundongos , Raízes de Plantas/química , Espectrometria de Massas de Bombardeamento Rápido de Átomos , Espectrofotometria Infravermelho , Espectrofotometria Ultravioleta , Células Tumorais CultivadasRESUMO
The effect of some flavonoids on the K(+)-dependent and K(+)-independent leucine uptake into brush border membrane vesicles from Bombyx mori larval midgut was investigated. Among the compounds tested, cyclochampedol, recently purified from Artocarpus champeden, was able to inhibit in micromolar range the leucine transport. The inhibition occurred both in the absence and in the presence of potassium and was not affected by leucine concentration. The apparent Ki was 0.25 mM. Cyclochampedol represents the first non-competitive inhibitor of an amino acid transport system in Lepidoptera. The relevance of this result is discussed.