[The relationship between the relative length of leukocyte telomeres and mtDNA copy number and acute coronary syndrome in a 15-year follow-up.]

OBJECTIVE: to study the association of relative leukocyte DNA telomere length with death from natural causes during a 15-year follow-up in a middle-aged and elderly Siberian population. Study of the association of the relative length of leukocyte telomeres (LTL) with fatal outcomes during a 15-year follow-up of a random population sample formed in 2003-2005 (n=9 360, 45-69 years old, Novosibirsk, HAPIEE project). The main group included the persons died from natural causes (except external) without a previous history of CVD and cancer (n=609); controls were stratified by sex and age (n=799). The analysis of relative LTL at baseline was performed using quantitative real-time PCR. We estimated the odds ratio of all-cause death per 1 decile shortening of LTD as a continuous variable in a multivariable-adjusted logistic regression. The carriers of shorter telomere carriers had an increased risk of death from natural causes over the next 15 years (OR=1,37, 95% CI 1,31-1,44) per decile of LTL decrease, regardless of other factors. The risk coefficients were similar for death from CVD (1,39), cancer (1,42), and other non-external causes (1,51). In studied middle-aged and elderly Siberian (Caucasoid) population cohort the LTL was an independent inverse predictor of the 15-year risk of death from natural causes.

[Frequency of detection the of Brugada syndrome signs in the course of ECG registration].

The aim of the study was to assess prevalence of the Brugada syndrome during carrying out ECG in the conditions of medico-sanitary division of a large industrial enterprise. Signs of the Brugada syndrome were found on 20 of 42779 ECGs (0.047%) registered during 1 year in patients aged 22-68 years. Type 2 syndrome was noted in 4 patients, others had type 2 of the syndrome. Men comprised 90% of patients. At 24 hour ECG monitoring paroxysm of nonsustained ventricular tachycardia was registered in 1 patient during night hours. Cases of sudden death were registered in families of 3 patients (all men older than 45 years). Four patients experienced syncopi clinical picture of which resembled more neurocardiogenic but not arrhythmic attacks. Thus prevalence of the Brugada syndrome in our population was quite low.