A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication.

Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication.

Adults' reactions to the death of a parent: a preliminary study.

The authors conducted a systematic psychodynamic investigation directed explicitly toward the bereavement reactions of people who have lost a parent during their adult life. They conducted a single in-depth interview of 14 people with a mean age of 32.4 years who had experienced the death of a parent in the last 3--20 months. The authors present clinical data illustrating several themes, including the importance of the last meeting with the parent, the experience of grief and aggression, coping resources, and growth-oriented aspects of the bereavement process. They also make a number of suggestions regarding clinical practice and further research.