[An experimental study of the anti-ulcer effect of administering sodium succinate and a solution of whey in immobilization stress]. / Eksperimental'ne vyvchennia antyvyrazkovoho efektu vvedennia iantarnokysloho natriiu ta rozchynu molochnoï syrovatky pry immobilizatsiinomu stresi.

The experiments carried out on the model of immobilization stress permit establishing the antiulcer effect of preventive introduction of sodium succinate solution, milk serum solution and solution of milk serum with sodium succinate. A decrease in the degree and number of ulcers and in the integrative indices characterizing the ulcer process after introduction of the studied drugs was accompanied by a fall of the intensity of lipid peroxidation processes.

[An electron microscopic analysis of the stimulating and toxic effects of mumie-containing preparations]. / Elektronno-mikroskopicheskii analiz stimuliruiushchego i toksicheskogo éffektov mumiesoderzhashchikh preparatov.

Ultrastructural changes of myocardium cells, neurons of sensorimotor cerebral cortex, endothelium of blood microvessels were registered by transmissive electron microscopy in mice receiving rock balm preparations per os. Both stimulating and toxic effects were observed dependently on used concentrations. This necessitates dosage to be strictly observed.

[Combined use of antitubercular drugs and metabolites of the tricarboxylic acid cycle in experimental tuberculosis]. / Sochetannoe primenenie protivotuberkuleznykh preparatov i metabolitov trikarbonovogo tsikla pri éksperimental'nom tuberkuleze.

The efficacy of a combined use of isoniazid together with polyzid prolonged tuberculostatic and tricarboxylic acid cycle metabolites was experimentally studied in guinea pigs. Mortality rates, pathomorphologic test data and the extent of tuberculous affection in the animals confirm a fairly high efficacy of prolonged polyzid in combination with succinate and malate as pathogenetic drugs.

[Effect of exogenous succinate on the contents of tricarboxylic acid cycle metabolites of the liver]. / Vliianie ékzogennogo suktsinata na soderzhanie metabolitov trikarbonovogo tsikla v pecheni.

The paper deals with dynamics of tricarboxylic cycle metabolites in the liver after subcutaneous injection of succinate in a dose of 100 mg/kg to guinea pigs. Before the preparation administration the highest level was marked for succinate, malate and citrate. 3 h after the administration the succinate content increased by 57% and 6 h later it returns to the initial level. No essential changes were observed in the content of other tricarboxylic acid cycle metabolites.

[Effect of tubaside and sodium succinate on oxidative phosphorylation and p-hydroxylation in the liver]. / Vliianie tubazida i suktsinata natriia na okislitel'noe fosforilirovanie i p-gidroksilirovanie v pecheni.

Tubaside causes disturbances in oxidative phosphorylation of the liver mitochondria. Sodium succinate administered during tubaside intoxication favours normalization of the oxygen uptake rate in state 3 and the ADP phosphorylation rate. Sodium succinate weakens the toxic effect of tubaside and favours normalization of p-hydroxylation in the liver. The animals, which were given tubaside in combination with sodium succinate are characterized by a higher survival rate.