Simple colorimetric method for determination of terbutaline sulfate from pharmaceutical preparations.

A simple colorimetric method is described for the determination of terbutaline sulfate. The method is based on measurement of a colored species formed when terbutaline sulfate is treated with diazotized dapsone and p-nitroaniline at room temperature. Compounds such as starch, talc, and common excipients do not interfere in the reaction. Statistical validation showed that the method was highly precise and accurate. The results agree well with those obtained by other methods reported in the literature.

A simple spectrophotometric method for the determination of nylidrin hydrochloride, isoxsuprine hydrochloride and salbutamol sulphate in pharmaceutical preparations.

A simple spectrophotometric method for the determination of nylidrin hydrochloride, isoxsuprine hydrochloride and salbutamol sulphate is described, based on measurement of the orangeyellow species produced when the drugs are coupled with diazotized benzocaine (p-aminoethyl benzoate) in trimethylamine medium. The method is applicable over the range 1-12 mug ml for isoxsuprine hydrochloride and nylidrin hydrochloride and 1-8 mug ml for salbutamol sulphate. The method is a modification of the Bratton-Marshall reaction and is simple, reproducible, accurate and more sensitive than those cited in the literature.