RESUMO
A new original drug dimetpramid injected per os into mice and rats exhibits moderate toxicity, exerts a weak irritating action on the mucous membranes. The drug is capable of penetrating via the unaffected skin, producing systemic effects. With all routes of administration the drug may have a moderate inhibitory action on ovarian function and the manifestation of the hypotensive effect.
Assuntos
Antieméticos/toxicidade , Benzamidas/toxicidade , Animais , Antieméticos/administração & dosagem , Benzamidas/administração & dosagem , Relação Dose-Resposta a Droga , Estro/efeitos dos fármacos , Feminino , Cobaias , Dose Letal Mediana , Camundongos , Coelhos , Ratos , Fatores de TempoAssuntos
Poluentes Ocupacionais do Ar/toxicidade , Sulfaleno/toxicidade , Sulfanilamidas/toxicidade , Poluentes Ocupacionais do Ar/intoxicação , Animais , Relação Dose-Resposta a Droga , Feminino , Cobaias , Masculino , Concentração Máxima Permitida , Camundongos , Ratos , Sulfaleno/intoxicação , Fatores de TempoRESUMO
It has been demonstrated that dimethpramide exerted an adverse effect on the sexual glands of female rats. It provoked an inhibition of ovarian function (derangement of cycling rhythmicity, the loss of individual cycle stages) and depletion of energy resources of the uterus (drop of glycogen content). The reduction of the gonadotropic activity of the pituitary was also observed.
