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1.
Anesteziol Reanimatol ; (1): 8-10, 1994.
Artigo em Russo | MEDLINE | ID: mdl-8010517

RESUMO

Changes in superoxide dismutase (SOD), catalase (C), and peroxidase (P) blood activity, as well as the activity of glucose-6-phosphate dehydrogenase (G-6-PDH), isocitrate dehydrogenase (ICDH), malate dehydrogenase (MDH), and peroxide resistance of erythrocytes (PRE) have been studied in 45 gastroenterologic patients under different types of general anesthesia. A significant increase in G-6-PDH, SOD, K, P activity and an increase in ICDH and MDH activity, as well as a drop in PRE which tends to return to baseline postoperatively have been established during general anesthesia. SOD expressed the greatest intergroup differences. A fragment of mechanism of energy transfer in the erythrocyte aimed at hemoglobin oxygenation and tissue hypoxia compensation has been suggested.


Assuntos
Anestesia Geral , Eritrócitos/metabolismo , Peróxido de Hidrogênio/sangue , Adulto , Idoso , Catalase/sangue , Procedimentos Cirúrgicos do Sistema Digestório , Eritrócitos/enzimologia , Feminino , Glucosefosfato Desidrogenase/sangue , Humanos , Peróxido de Hidrogênio/metabolismo , Isocitrato Desidrogenase/sangue , Malato Desidrogenase/sangue , Masculino , Pessoa de Meia-Idade , Peroxidases/sangue , Período Pós-Operatório , Superóxido Dismutase/sangue , Fatores de Tempo
2.
Anesteziol Reanimatol ; (6): 20-2, 1990.
Artigo em Russo | MEDLINE | ID: mdl-2075923

RESUMO

Spontaneous and evoked omega-potentials were registered, using high-ohm amplifier of the permanent current and non-polarized liquid minute chlorine-silver electrodes, in 40 surgical patients 40-60 min after premedication. It has been established that effective premedication in 77% of cases (29 patients) correlated with low stable (variability 1-2 mV) values of omega-potential ranging from 0 to 20 mV and an omegagram in the form of a conventionally straight line in response to the functional load. In 11 patients with ineffective premedication the functional load caused phase, smooth or uneven changes in omega-potential (variability from 5 to 27 mV), with both low (0-20 mV) and intermediate (21-40 mV) initial values. Hexenal consumption was twice lower in patients with effective than in patients with ineffective premedication. It is concluded that omegametry can be used as an effective criterion in the assessment of premedication efficacy.


Assuntos
Encéfalo/fisiologia , Hipnóticos e Sedativos/administração & dosagem , Medicação Pré-Anestésica , Procedimentos Cirúrgicos Operatórios , Adulto , Idoso , Encéfalo/efeitos dos fármacos , Eletrofisiologia , Estudos de Avaliação como Assunto , Humanos , Pessoa de Meia-Idade
3.
Anesteziol Reanimatol ; (3): 66-8, 1989.
Artigo em Russo | MEDLINE | ID: mdl-2802252

RESUMO

Omegametry was performed to 114 patients with peritonitis at various phases of the disease. Six types of omegagrams have been obtained. Reactive phase of peritonitis was characterized by monophase changes in omega-potential after a functional load with positive or negative monophase waves and an omegagram in the form of a straight line with baseline values of omega-potential 24 to 40 mV. In toxic phase of peritonitis monophase changes in omega-potential were observed after the functional load with a positive or negative incomplete phase. Omegagrams in the form of a straight line with baseline values of omega-potential 2 to 15 mV or chaotic changing curve were revealed in terminal stage of peritonitis. The data obtained make it possible to diagnose peritonitis phase, optimize intensive care and predict the outcome of the disease.


Assuntos
Peritonite/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Eletrofisiologia , Humanos , Pessoa de Meia-Idade , Peritonite/fisiopatologia
5.
Biull Eksp Biol Med ; 92(12): 699-701, 1981 Dec.
Artigo em Russo | MEDLINE | ID: mdl-6799014

RESUMO

It was established that the activity of blood and gastric mucosa carboanhydrase increased after the introduction of food irritant (milk) into the stomach, as well as after the subcutaneous injection of histamine. This was accompanied by the increase of pepsinogen content in the gastric mucosa. When introduced into the stomach before the food irritant or histamine, acetazolamide inhibited blood and gastric mucosa carboanhydrase and reduced the content of pepsinogen in the gastric mucosa. Oral administration of acetazolamide for 5 days resulted in a more remarkable inhibition of blood and gastric mucosa carboanhydrase and in a drastically reduced content of pepsinogen in the gastric mucosa. The rate of pepsinogen biosynthesis by the gastric mucosa seems to depend on the activity of carboanhydrase in blood and in the gastric mucosa.


Assuntos
Acetazolamida/farmacologia , Anidrases Carbônicas/metabolismo , Mucosa Gástrica/metabolismo , Pepsinogênios/análise , Acetazolamida/administração & dosagem , Animais , Anidrases Carbônicas/sangue , Dieta , Histamina/administração & dosagem , Masculino , Leite
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