[Rationale for using kinin system inhibitors in patients with acute ischemia and infarction of the myocardium during the prehospital phase]. / Ob obosnovannosti ispol'zovaniia na dogospital'nom étape ingibitorov kininovoi sistemy u bol'nykh s ostroi ishemiei i infarktom miokarda.

The paper discusses if it is advisable to use kallikrein-kinin system inhibitors earlier. A total of 122 patients with acute ischemia and infarction of the myocardium were studied. Contrykal and heparin infused in the prehospital period, followed by hospital treatment are optimal to prevent vascular wall lesions, maximally retain retrograde blood flow, and substantially reduce the size of myocardial infarction. Therapy with protease inhibitors proved to be most beneficial within the first 2 hours of the disease, as evidenced by a profound improvement in the clinical course of myocardial infarction, a decrease in ECG and precordial mapping signs of ischemia, a positive change in myoglobin and MB creatine phosphokinase levels, and a significant reduction in the rehabilitative period.

[Hemodynamic shifts in patients with congestive heart failure during treatment with sodium nitroprusside]. / Gemodinamicheskie sdvigi pri lechenii nitroprussidom natriia bol'nykh s zastoinoi serdechnoi nedostatochnost'iu.

Hemodynamic effects of sodium nitroprussid were studied in 21 patients with congestive heart failure. Nitroprussid reduced systemic arterial pressure, pulmonary artery pressure, pulmonary capillary wedge pressure, systemic and pulmonary vascular resistance, and increased cardiac index and left-ventricular stroke performance index, thus reducing the pre- and post-load of the left ventricle and improving its functional capacity.