Stationary particle currents in sedimenting active matter wetting a wall.

Recently it was predicted, on the basis of a lattice gas model, that scalar active matter in a gravitational field would rise against gravity up a confining wall or inside a thin capillary-in spite of repulsive particle-wall interactions [Phys. Rev. Lett. 124, 048001 (2020)0031-900710.1103/PhysRevLett.124.048001]. In this paper we confirm this prediction with sedimenting active Brownian particles (ABPs) in a box numerically and elucidate the mechanism leading to the formation of a meniscus rising above the bulk of the sedimentation region. The height of the meniscus increases with the activity of the system, algebraically with the Péclet number. The formation of the meniscus is determined by a stationary circular particle current, a vortex, centered at the base of the meniscus, whose size and strength increase with the ABP activity. The origin of these vortices can be traced back to the confinement of the ABPs in a box: already the stationary state of ideal (noninteracting) ABPs without gravitation displays circular currents that arrange in a highly symmetric way in the eight octants of the box. Gravitation distorts this vortex configuration downward, leaving two major vortices at the two side walls, with a strong downward flow along the walls. Repulsive interactions between the ABPs change this situation only as soon as motility induced phase separation (MIPS) sets in and forms a dense, sedimented liquid region at the bottom, which pushes the center of the vortex upwards towards the liquid-gas interface. Self-propelled particles therefore represent an impressive realization of scalar active matter that forms stationary particle currents being able to perform visible work against gravity or any other external field, which we predict to be observable experimentally in active colloids under gravitation.

Jamming and flocking in the restricted active Potts model.

We study the active Potts model with either site occupancy restriction or on-site repulsion to explore jamming and kinetic arrest in a flocking model. The incorporation of such volume exclusion features leads to a surprisingly rich variety of self-organized spatial patterns. While bands and lanes of moving particles commonly occur without or under weak volume exclusion, strong volume exclusion along with low temperature, high activity, and large particle density facilitates jams due to motility-induced phase separation. Through several phase diagrams, we identify the phase boundaries separating the jammed and free-flowing phases and study the transition between these phases which provide us with both qualitative and quantitative predictions of how jamming might be delayed or dissolved. We further formulate and analyze a hydrodynamic theory for the restricted APM which predicts various features of the microscopic model.

Flocking of two unfriendly species: The two-species Vicsek model.

We consider the two-species Vicsek model (TSVM) consisting of two kinds of self-propelled particles, A and B, that tend to align with particles from the same species and to antialign with the other. The model shows a flocking transition that is reminiscent of the original Vicsek model: it has a liquid-gas phase transition and displays micro-phase-separation in the coexistence region where multiple dense liquid bands propagate in a gaseous background. The interesting features of the TSVM are the existence of two kinds of bands, one composed of mainly A particles and one mainly of B particles, the appearance of two dynamical states in the coexistence region: the PF (parallel flocking) state in which all bands of the two species propagate in the same direction, and the APF (antiparallel flocking) state in which the bands of species A and species B move in opposite directions. When PF and APF states exist in the low-density part of the coexistence region they perform stochastic transitions from one to the other. The system size dependence of the transition frequency and dwell times show a pronounced crossover that is determined by the ratio of the band width and the longitudinal system size. Our work paves the way for studying multispecies flocking models with heterogeneous alignment interactions.

Narrow escape problem in two-shell spherical domains.

Intracellular transport in living cells is often spatially inhomogeneous with an accelerated effective diffusion close to the cell membrane and a ballistic motion away from the centrosome due to active transport along actin filaments and microtubules, respectively. Recently it was reported that the mean first passage time (MFPT) for transport to a specific area on the cell membrane is minimal for an optimal actin cortex width. In this paper, we ask whether this optimization in a two-compartment domain can also be achieved by passive Brownian particles. We consider a Brownian motion with different diffusion constants in the two shells and a potential barrier between the two, and we investigate the narrow escape problem by calculating the MFPT for Brownian particles to reach a small window on the external boundary. In two and three dimensions, we derive asymptotic expressions for the MFPT in the thin cortex and small escape region limits confirmed by numerical calculations of the MFPT using the finite-element method and stochastic simulations. From this analytical and numeric analysis, we finally extract the dependence of the MFPT on the ratio of diffusion constants, the potential barrier height, and the width of the outer shell. The first two are monotonous, whereas the last one may have a minimum for a sufficiently attractive cortex, for which we propose an analytical expression of the potential barrier height matching very well the numerical predictions.

Flocking with a q-fold discrete symmetry: Band-to-lane transition in the active Potts model.

We study the q-state active Potts model (APM) on a two-dimensional lattice in which self-propelled particles have q internal states corresponding to the q directions of motion. A local alignment rule inspired by the ferromagnetic q-state Potts model and self-propulsion via biased diffusion according to the internal particle states elicits collective motion at high densities and low noise. We formulate a coarse-grained hydrodynamic theory with which we compute the phase diagrams of the APM for q=4 and q=6 and analyze the flocking dynamics in the coexistence region, where the high-density (polar liquid) phase forms a fluctuating stripe of coherently moving particles on the background of the low-density (gas) phase. A reorientation transition of the phase-separated profiles from transversal band motion to longitudinal lane formation is found, which is absent in the Vicsek model and the active Ising model. The origin of this reorientation transition is revealed by a stability analysis: for large velocities the transverse diffusivity approaches zero and stabilizes lanes. Computer simulations corroborate the analytical predictions of the flocking and reorientation transitions and validate the phase diagrams of the APM.

Role of nonconservative scattering forces and damping on Brownian particles in optical traps.

We consider a model of a particle trapped in a harmonic optical trap but with the addition of a nonconservative radiation induced force. This model is known to correctly describe experimentally observed trapped particle statistics for a wide range of physical parameters, such as temperature and pressure. We theoretically analyze the effect of nonconservative force on the underlying steady state distribution as well as the power spectrum for the particle position. We compute perturbatively the probability distribution of the resulting nonequilibrium steady states for all dynamical regimes underdamped through to overdamped and give expressions for the associated currents in phase space (position and velocity). We also give the spectral density of the trapped particle's position in all dynamical regimes and for any value of the nonconservative force. Signatures of the presence of nonconservative forces are shown to be particularly strong for the underdamped regime at low frequencies.

Nonequilibrium Dynamics Induced by Scattering Forces for Optically Trapped Nanoparticles in Strongly Inertial Regimes.

The forces acting on optically trapped particles are commonly assumed to be conservative. Nonconservative scattering forces induce toroidal currents in overdamped liquid environments, with negligible effects on position fluctuations. However, their impact in the underdamped regime remains unexplored. Here, we study the effect of nonconservative scattering forces on the underdamped nonlinear dynamics of trapped nanoparticles at various air pressures. These forces induce significant low-frequency position fluctuations along the optical axis and the emergence of toroidal currents in both position and velocity variables. Our experimental and theoretical results provide fundamental insights into the functioning of optical tweezers and a means for investigating nonequilibrium steady states induced by nonconservative forces.

Bystander cells enhance NK cytotoxic efficiency by reducing search time.

Natural killer (NK) cells play a central role during innate immune responses by eliminating pathogen-infected or tumorigenic cells. In the microenvironment, NK cells encounter not only target cells but also other cell types including non-target bystander cells. The impact of bystander cells on NK killing efficiency is, however, still elusive. In this study we show that the presence of bystander cells, such as P815, monocytes or HUVEC, enhances NK killing efficiency. With bystander cells present, the velocity and persistence of NK cells were increased, whereas the degranulation of lytic granules remained unchanged. Bystander cell-derived H2O2 was found to mediate the acceleration of NK cell migration. Using mathematical diffusion models, we confirm that local acceleration of NK cells in the vicinity of bystander cells reduces their search time to locate target cells. In addition, we found that integrin ß chains (ß1, ß2 and ß7) on NK cells are required for bystander-enhanced NK migration persistence. In conclusion, we show that acceleration of NK cell migration in the vicinity of H2O2-producing bystander cells reduces target cell search time and enhances NK killing efficiency.

Quantitative approximation schemes for glasses.

By means of a systematic expansion around the infinite-dimensional solution, we obtain an approximation scheme to compute properties of glasses in low dimensions. The resulting equations take as input the thermodynamic and structural properties of the equilibrium liquid, and from this they allow one to compute properties of the glass. They are therefore similar in spirit to the Mode Coupling approximation scheme. Our scheme becomes exact, by construction, in dimension d→∞, and it can be improved systematically by adding more terms in the expansion.