Risk-adjusted benchmarking of long-term overall survival in patients with HER2-positive early-stage Breast cancer: A Swedish retrospective cohort study.

AIM: The main objective of the current study was to explore the value of risk-adjustment when comparing (i.e. benchmarking) long-term overall survival (OS) in breast cancer (BC) between Swedish regions. We performed risk-adjusted benchmarking of 5- and 10-year OS after HER2-positive early BC diagnosis between Sweden's two largest healthcare regions, constituting approximately a third of the total population in Sweden. METHODS: All patients diagnosed with HER2-positive early-stage BC between 01-01-2009 and 31-12-2016 in healthcare regions Stockholm-Gotland and Skane were included in the study. Cox proportional hazards model was used for risk-adjustment. Unadjusted (i.e. crude) and adjusted 5- and 10-year OS was benchmarked between the two regions. RESULTS: The crude 5-year OS was 90.3% in the Stockholm-Gotland region and 87.8% in the Skane region. The crude 10-year OS was 81.7% in the Stockholm-Gotland region and 77.3% in the Skane region. However, when adjusted for age, menopausal status and tumour biology, there was no significant OS disparity between the regions, neither at the 5-year nor 10-year follow-up. CONCLUSION: This study showed that risk-adjustment is relevant when benchmarking OS in BC, even when comparing regions from the same country that share the same national treatment guidelines. This is, to our knowledge, the first published risk-adjusted benchmarking of OS in HER2-positive BC.

Human Activity Recognition with an HMM-Based Generative Model.

Human activity recognition (HAR) has become an interesting topic in healthcare. This application is important in various domains, such as health monitoring, supporting elders, and disease diagnosis. Considering the increasing improvements in smart devices, large amounts of data are generated in our daily lives. In this work, we propose unsupervised, scaled, Dirichlet-based hidden Markov models to analyze human activities. Our motivation is that human activities have sequential patterns and hidden Markov models (HMMs) are some of the strongest statistical models used for modeling data with continuous flow. In this paper, we assume that emission probabilities in HMM follow a bounded-scaled Dirichlet distribution, which is a proper choice in modeling proportional data. To learn our model, we applied the variational inference approach. We used a publicly available dataset to evaluate the performance of our proposed model.