RESUMO
This case series describes the clinical and laboratory profile of 15 patients with tuberculosis (TB) HIV coinfection admitted to a referral centre in the Islamic Republic of Iran. Most of the patients (13) were male; the mean age was 36.9 years. Intravenous drug use was the route of transmission for all males and heterosexual intercourse for the 2 females; 12 patients had a history of imprisonment. All patients had pulmonary TB; 13 were smear-positive and all except 1 had atypical radiological presentation. Drug-induced hepatitis occurred in 3 patients and 12 had hepatitis C coinfection. Five patients died. The mean CD4 count was 229.2 (SD 199.5) cells/mm3 and 78.6% had CD4 count < 350. TB may be an AIDS-defining illness in this country.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/epidemiologia , Tuberculose Pulmonar/epidemiologia , Infecções Oportunistas Relacionadas com a AIDS/sangue , Infecções Oportunistas Relacionadas com a AIDS/complicações , Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Adulto , Distribuição por Idade , Contagem de Linfócito CD4 , Doença Hepática Induzida por Substâncias e Drogas/epidemiologia , Distribuição de Qui-Quadrado , Comorbidade , Feminino , Hepatite C/epidemiologia , Hospitais Urbanos , Humanos , Irã (Geográfico)/epidemiologia , Masculino , Pessoa de Meia-Idade , Vigilância da População , Prisioneiros/estatística & dados numéricos , Encaminhamento e Consulta , Fatores de Risco , Distribuição por Sexo , Comportamento Sexual , Abuso de Substâncias por Via Intravenosa/complicações , Inquéritos e Questionários , Tuberculose Pulmonar/sangue , Tuberculose Pulmonar/complicações , Tuberculose Pulmonar/diagnósticoRESUMO
This case series describes the clinical and laboratory profile of 15 patients with tuberculosis [TB] HIV coinfection admitted to a referral centre in the Islamic Republic of Iran. Most of the patients [13] were male; the mean age was 36.9 years. Intravenous drug use was the route of transmission for all males and heterosexual intercourse for the 2 females; 12 patients had a history of imprisonment. All patients had pulmonary TB; 13 were smear-positive and all except 1 had atypical radiological presentation. Drug-induced hepatitis occurred in 3 patients and 12 had hepatitis C coinfection. Five patients died. The mean CD4 count was 229.2 [SD 199.5] cells/mm[3] and 78.6% had CD4 count < 350. TB may be an AIDS-defining illness in this country
Assuntos
Tuberculose , HIV , Contagem de Linfócito CD4 , Ensaio de Imunoadsorção Enzimática , Hepatite C , Inquéritos e Questionários , Testes de Sensibilidade Microbiana , Citometria de FluxoRESUMO
Nearly 18% of tuberculosis (TB) cases have only extrapulmonary manifestations. Breast tuberculosis is a rare type of extrapulmonary TB. This paper reports 4 cases of breast TB confirmed either pathologically or mycobacteriologically or both. These reports showed that TB should always be considered first in the differential diagnosis of granulomatous mastitis in TB-endemic areas. Therapy included at least 6 months of anti-TB medication and surgery when indicated.
Assuntos
Granuloma , Mastite , Tuberculose , Adulto , Antituberculosos/uso terapêutico , Biópsia por Agulha , Terapia Combinada , Diagnóstico Diferencial , Quimioterapia Combinada , Feminino , Granuloma/diagnóstico , Granuloma/tratamento farmacológico , Granuloma/epidemiologia , Humanos , Irã (Geográfico)/epidemiologia , Mamografia , Mastectomia , Mastite/diagnóstico , Mastite/tratamento farmacológico , Mastite/epidemiologia , Pessoa de Meia-Idade , Vigilância da População , Doenças Raras , Resultado do Tratamento , Tuberculina , Tuberculose/diagnóstico , Tuberculose/tratamento farmacológico , Tuberculose/epidemiologiaRESUMO
Nearly 18% of tuberculosis [TB] cases have only extrapulmonary manifestations. Breast tuberculosis is a rare type of extrapulmonary TB. This paper reports 4 cases of breast TB confirmed either pathologically or mycobacteriologically or both. These reports showed that TB should always be considered first in the differential diagnosis of granulomatous mastitis in TB-endemic areas. Therapy included at least 6 months of anti-TB medication and surgery when indicated
Assuntos
Mama , Tuberculose , Mastite , Biópsia por Agulha Fina , Ultrassonografia Mamária , Doenças MamáriasRESUMO
There is little information on atypical mycobacterium and human T lymphotropic virus Type I (HTLV-I) co-infection. We present the first case of pulmonary M. simiae infection in co-infection with HTLV-1, confirmed by ELISA antibody test and Western Blot. We discuss the clinical characteristics and laboratory tests of the patient and presumptive immunological relation. We propose that in patients with the HTLV infection and pulmonary symptoms and signs compatible with tuberculosis, evaluation for atypical mycobacteriosis may be recommendable.
Assuntos
Infecções por HTLV-I/complicações , Infecções por Mycobacterium não Tuberculosas/complicações , Micobactérias não Tuberculosas , Western Blotting , Ensaio de Imunoadsorção Enzimática , Feminino , Anticorpos Anti-HTLV-I/sangue , Humanos , Pessoa de Meia-Idade , Infecções por Mycobacterium não Tuberculosas/microbiologia , Fatores de RiscoRESUMO
BACKGROUND: Tuberculosis is one of the most common infectious diseases in the world. In recent years, genetically approach has been developed. One of the interesting gene for investigator is IFN-gammaR1. AIM: Determination of susceptibility to tuberculosis with polymorphism of IFN-gammaR1 gene. MATERIAL AND METHOD: Study was prospective case-control. Fifty patients with smear positive tuberculosis have been chosen randomly. They were matched with 54 healthy controls with no history of TB. Polymorphism at 395 codon of IFN-gammaR1 gene was detected with Newport method. Data were analysed with SPSS version 11. RESULTS: Mean age of patients and control were 55+/-20 and 53+/-13.5 years, respectively. Demographic characteristic had no difference within two groups. One patient in case group had heterozygote mutation at IFN-gammaR1 gene. In control group there were no mutations. CONCLUSION: Genetically susceptibility to TB is not in 395 colon of IFN-gammaR1 in Iranian TB sample and polymorphism of this loci has occur in 2% of TB patients and 0.96% of total study population.
Assuntos
Polimorfismo Genético , Receptores de Interferon/genética , Tuberculose Pulmonar/genética , Adulto , Idoso , Feminino , Predisposição Genética para Doença/genética , Humanos , Irã (Geográfico)/epidemiologia , Masculino , Pessoa de Meia-Idade , Mutação , Fatores de Risco , Tuberculose Pulmonar/epidemiologia , Receptor de Interferon gamaRESUMO
Primary multi-drug resistant extrapulmonary tuberculosis is an uncommon form of the disease, but it seems that by increasing the number drug resistant tuberculosis around the world, the number of cases of primary multi-drug resistant tuberculosis with extrapulmonary presentation also is going to rise. In this report, we describe a 19-year old, HIV negative man with primary multi-drug resistant TB lymphadenitis, presented with cervical lymphadenopathy and sinus discharge at the site of involved lymph nodes. The Acid Fast Bacilli (AFB) smear of sputum was negative but the AFB smear of discharged fluid as well as the excisional biopsy of the lymph nodes confirmed the M. tuberculosis infection. The patient underwent the treatment with a combination of isoniazide, clofazimine, pyrazinamide, ofloxacin and amikacin with promising results. By increasing the number of drug resistant tuberculosis patients around the world, appropriate diagnosis and treatment of different presentations of the disease need a special attention.