Qualitative and quantitative comparison of gated blood pool single photon emission computed tomography using low-energy high-resolution and SMARTZOOM collimation.

OBJECTIVE: The aim of this study was to assess the feasibility of IQ-SPECT gated blood pool (MUGA) under conditions of decreased scan time (ST). PATIENTS AND METHODS: Ten patients underwent routine 26-min, two-view planar, followed by LEHR and IQ-SPECT MUGA, on a Siemens dual-head Symbia scanner. Six 'back and forth' 4-min SPECT scans were summed into 4-, 8-, 12-, 16-, 20-, and 24-min equivalent scans, and reconstructed iteratively (IQ-SPECT and LEHR) and with FBP (LEHR). Uniformity, contrast, and wall motion were scored on a five-point scale. Linear regressions of left ventricular (LV) ejection fraction (EF) were performed between FBP, Flash 3D, and IQ-SPECT versus planar and Flash 3D and IQ-SPECT versus FBP. Agreement tables between Flash 3D and IQ-SPECT versus FBP LV EF were generated using a normal versus cardiotoxicity threshold of 50%. RESULTS: IQ-SPECT had the best scores for all STs, and 4, 8, and 16 min IQ-SPECT were judged to be similar to 24-min LEHR FBP, Flash 3D, and planar, respectively. The average LV EF correlation coefficients were 0.69, 0.71, and 0.63 between IQ-SPECT, Flash 3D, and FBP versus planar, respectively; 0.70 between IQ-SPECT and FBP; and 0.88 between Flash 3D and FBP, and all were statistically significant (P<0.05), except for 16-min FBP LEHR versus planar. Agreement tables showed diagnostic equivalence of IQ-SPECT, Flash 3D, and FBP. CONCLUSION: These preliminary results suggest that IQ-SPECT is equivalent to LEHR Flash 3D and FBP for MUGA SPECT, and better at reduced ST. A larger patient population study is necessary for a more definitive assessment.

False-positive pericardial effusion due to breast attenuation on equilibrium radionuclide angiocardiography.

UNLABELLED: Equilibrium radionuclide angiocardiography (ERNA) scans are used to evaluate left ventricular function and pericardial anatomy. A photopenic "U-halo" around the cardiac blood pool in the left anterior oblique (LAO) view is commonly seen with pericardial effusion. We describe findings of false-positive pericardial effusion due to breast attenuation in cancer patients. METHODS: Several cases that demonstrated the photopenic U-halo in the LAO view did not have true pericardial effusion. The patients' breast size and how far the breast sagged in reference to the heart silhouette were visually observed in topograms. The oblique tilt position was evaluated to determine the effect it may have in creating the photopenic U-halo. A unique ERNA case demonstrating collateral vessels bilaterally in the breasts was used as a reference marker image to determine the effect of a slightly more anterior versus left lateral oblique tilt in the LAO view. RESULTS: Large breasts can overlie the heart in the LAO projection. The overlying breast can cause the appearance of pericardial effusion in the resulting image by attenuating tissues surrounding the heart. The positioning of the breast also affected the appearance of the photopenic halo. A patient with breast implants who had more upright breasts demonstrated a photopenic area anterior to the left ventricle, whereas a large breast that sagged more laterally demonstrated no photopenic area. CONCLUSION: Patients with large breasts may show a photopenic U-halo in the LAO view dependent on how far the breast sags in reference to the heart silhouette and on the positioning of the oblique tilt. The anterior image should be used to distinguish breast attenuation from a photopenic area surrounding the heart. If both the anterior view and the LAO view demonstrate the U-halo, acquiring another view with a slightly more anterior or lateral oblique position will demonstrate any inconsistency in the photopenic area, thereby excluding a diagnosis of pericardial effusion.

Hybrid Modality Fusion of Planar Scintigrams and CT Topograms to Localize Sentinel Lymph Nodes in Breast Lymphoscintigraphy: Technical Description and Phantom Studies.

Lymphoscintigraphy is a nuclear medicine procedure that is used to detect sentinel lymph nodes (SLNs). This project sought to investigate fusion of planar scintigrams with CT topograms as a means of improving the anatomic reference for the SLN localization. Heretofore, the most common lymphoscintigraphy localization method has been backlighting with a (57)Co sheet source. Currently, the most precise method of localization through hybrid SPECT/CT increases the patient absorbed dose by a factor of 34 to 585 (depending on the specific CT technique factors) over the conventional (57)Co backlighting. The new approach described herein also uses a SPECT/CT scanner, which provides mechanically aligned planar scintigram and CT topogram data sets, but only increases the dose by a factor of two over that from (57)Co backlighting. Planar nuclear medicine image fusion with CT topograms has been proven feasible and offers a clinically suitable compromise between improved anatomic details and minimally increased radiation dose.

Acquisition parameters for oncologic imaging with a new SPECT/multislice CT scanner.

INTRODUCTION: Single photon emission computed tomography/computed tomography (SPECT/CT) delivers in a single imaging modality the functional-metabolic information from the SPECT image, combined with the detailed anatomical information from a diagnostic quality CT scanner. METHOD: In this review, we provide the details for the acquisition, processing, and display of the SPECT, as well as the CT, and the fused SPECT/CT images, with one of the newest devices that combines a dual-headed gamma camera with a multislice CT scanner. Also, we go over the performance characteristics, including the planning and installation requirements for this type of scanners. In addition, we describe what are the current and feasible near-future applications of this new and exciting hybrid imaging modality. DISCUSSION: The ability to combine an optimized state-of-the-art SPECT image, with resolutions down to 5 mm, with a diagnostic quality CT image-using slices as thin as 1.25 mm-provides a diagnostic advantage that potentially can deliver a more convenient and faster diagnosis, with clinical implications in a significant percentage of patients. This imaging technique has been investigated in a wide range of studies for the oncologic patient, including but not limited to bone scintigraphy, (111)In-pentetreotide scintigraphy, lymphoscintigraphy, (67)Ga and labeled leukocyte infection imaging, (131)I-metaiodobenzylguanidine, parathyroid scintigraphy, (131)I diagnostic scintigraphy, and (111)In ProstaScint, and for planning of radionuclide therapy. CONCLUSION: Therefore, this evolving and exciting imaging modality will continue to grow and define its place as an integral part of the evaluation of the cancer patient.

Sentinel node mapping in vulvovaginal melanoma using SPECT/CT lymphoscintigraphy.

We report 2 cases of vulvovaginal melanoma in which sentinel node mapping, performed using Tc-99m filtered sulfur colloid SPECT/CT lymphoscintigraphy, added important information to that provided by planar imaging and played a critical role in surgical planning and subsequent management. In the first case, lymphoscintigraphy planar imaging showed only foci of tracer uptake in the right groin and an equivocal focus in the left groin. SPECT/CT precisely localized these radioactive foci to the right and left inguinal sentinel nodes. The patient then underwent bilateral inguinal sentinel node sampling. In the second case, F-18 FDG PET/CT performed prior to lymphoscintigraphy demonstrated a moderately FDG-avid right inguinal lymph node that was indeterminate in nature. SPECT/CT revealed this lymph node to be a radioactive sentinel lymph node that was seen in the right groin on planar imaging. The patient then underwent right inguinal sentinel node sampling. Because pathologic study showed metastasis to the sentinel node, a planned pelvic exenteration was canceled, and the patient was referred for systemic treatment. Preoperative SPECT/CT lymphoscintigraphy is ideal for mapping the unpredicted lymphatic drainage pathways within the complex pelvic anatomy and this technique may also be used in the preoperative workup of other gynecologic malignancies.

Optimal (57)Co flood source activity and acquisition time for lymphoscintigraphy localization images.

UNLABELLED: We evaluated different (57)Co flood source activities and acquisition times to obtain an optimal localization image for breast lymphoscintigraphy that would adequately outline the body and allow detection of nodes seen on the emission scan while minimizing unnecessary radiation exposure to the patient. METHODS: An anthropomorphic thorax breast phantom representing an average-size patient was used to simulate nodes on a breast lymphoscintigraphy scan. The activities in the nodes at the time of acquisition ranged from 37 to 185 kBq (1-5 microCi). Four experiments were performed, consisting of 10-min emission and 3-min localization images. Anterior, posterior, and right and left lateral views of the thorax phantom were acquired, using each of 5 different (57)Co flood sources with activities ranging from 37 to 269 MBq (1.0-7.26 mCi). Ten 1-min localization images for each source were acquired and compared for quality. Three-minute localization images for 2 phantom thicknesses of 10 and 20 cm were acquired to determine the contrast-to-noise ratio for each (57)Co source. The total exposure was measured using an ion chamber survey meter. RESULTS: All sources allowed visualization of the lymphatic nodes in acquisitions as short as 3 min. Images using the 126-MBq (3.41-mCi) source demonstrated an adequate body outline along with visualization of all nodes seen on the emission image. The 37-MBq (1.0-mCi) source did not provide sufficient definition of the body outline, whereas the hotter sources decreased node visualization by increasing the background around the nodes at the same time that they increased the patient exposure. Node activity of 37 kBq (1 microCi) became undetectable on the anterior localization images yet was still visible on the lateral image because of greater attenuation of (57)Co photons. The estimated dose rate from the (57)Co sheet sources was 0.641 microSv/MBq/h. CONCLUSION: Acquiring a 3-min localization scan using a 126-MBq (3.41-mCi) source provided the best combination of clear-body outline and visualization of all nodes seen on the emission image. The estimated dose to the patient from the 126-MBq (3.41-mCi) sheet source was very low (8.7 microSv for unilateral and 13.1 microSv for bilateral). Node detectability decreased in localization images acquired using (57)Co sources of higher activity. This effect would be more pronounced in lymphoscintigrams of thin patients compared with those of patients of average thickness.

Evaluation and localization of lymphatic drainage and sentinel lymph nodes in patients with head and neck melanomas by hybrid SPECT/CT lymphoscintigraphic imaging.

In patients with head and neck tumors, preoperative lymphoscintigraphy can be used to map lymphatic drainage patterns and identify sentinel lymph nodes. However, it is very difficult to determine the exact locations of head and neck sentinel nodes on preoperative lymphoscintigraphy without the use of anatomic landmarks. Lymph nodes in the head and neck are grouped into 7 regions, or levels, on the basis of anatomic landmarks. In patients undergoing standard lymphoscintigraphy, obtaining lateral marker images that show important anatomic landmarks can help with the localization of sentinel nodes. However, technical problems often render marker images of little or no use. Hybrid SPECT/CT lymphoscintigraphic imaging facilitates the localization of sentinel nodes by reliably showing the relationships between sentinel nodes and important anatomic structures. After reading this article, the reader should understand the lymph node level classification system for head and neck melanomas, be able to describe the technique used for the imaging of sentinel nodes in the head and neck region, and be able to demonstrate how SPECT/CT lymphoscintigraphic imaging can enable precise sentinel node localization and thus help to ensure minimal dissection.

Attenuation correction of PET cardiac data with low-dose average CT in PET/CT.

We proposed a low-dose average computer tomography (ACT) for attenuation correction (AC) of the PET cardiac data in PET/CT. The ACT was obtained from a cine CT scan of over one breath cycle per couch position while the patient was free breathing. We applied this technique on four patients who underwent tumor imaging with 18F-FDG in PET/CT, whose PET data showed high uptake of 18F-FDG in the heart and whose CT and PET data had misregistration. All four patients did not have known myocardiac infarction or ischemia. The patients were injected with 555-740 MBq of 18F-FDG and scanned 1 h after injection. The helical CT (HCT) data were acquired in 16 s for the coverage of 100 cm. The PET acquisition was 3 min per bed of 15 cm. The duration of cine CT acquisition per 2 cm was 5.9 s. We used a fast gantry rotation cycle time of 0.5 s to minimize motion induced reconstruction artifacts in the cine CT images, which were averaged to become the ACT images for AC of the PET data. The radiation dose was about 5 mGy for 5.9 s cine duration. The selection of 5.9 s was based on our analysis of the respiratory signals of 600 patients; 87% of the patients had average breath cycles of less than 6 s and 90% had standard deviations of less than 1 s in the period of breath cycle. In all four patient studies, registrations between the CT and the PET data were improved. An increase of average uptake in the anterior and the lateral walls up to 48% and a decrease of average uptake in the septal and the inferior walls up to 16% with ACT were observed. We also compared ACT and conventional slow scan CT (SSCT) of 4 s duration in one patient study and found ACT was better than SSCT in depicting average respiratory motion and the SSCT images showed motion-induced reconstruction artifacts. In conclusion, low-dose ACT improved registration of the CT and the PET data in the heart region in our study of four patients. ACT was superior than SSCT for depicting average respiration motion in a patient study.

Lymphomatous involvement of gastrointestinal tract: evaluation by positron emission tomography with (18)F-fluorodeoxyglucose.

AIM: To demonstrate the (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) findings in patients with non-Hodgkinos lymphoma (NHL) involving the gastrointestinal (GI) tract and the clinical utility of modality despite of the known normal uptake of FDG in the GI tract. METHODS: Thirty-three patients with biopsy-proven gastrointestinal NHL who had undergone FDG-PET scan were included. All the patients were injected with 10-15 mCi FDG and scanned approximately 60 min later with a CTI/Siemens HR (+) PET scanner. PET scans were reviewed and the maximum standard uptake value (SUV(max)) of the lesions was measured before and after the treatment, if data were available and compared with histologic diagnoses. RESULTS: Twenty-five patients had a high-grade lymphoma and eight had a low-grade lymphoma. The stomach was the most common site of the involvement (20 patients). In high-grade lymphoma, PET showed focal nodular or diffuse hypermetabolic activity. The average SUV(max)+/-SD was 11.58+/-5.83. After the therapy, the patients whose biopsies showed no evidence of lymphoma had a lower uptake without focal lesions. The SUV(max)+/-SD decreased from 11.58+/-5.83 to 2.21+/-0.78. In patients whose post-treatment biopsies showed lymphoma, the SUV(max)+/-SD was 9.42+/-6.27. Low-grade follicular lymphomas of the colon and stomach showed diffuse hypermetabolic activity in the bowel wall (SUV(max) 8.2 and 10.3, respectively). The SUV(max) was 2.02-3.8 (mean 3.02) in the stomach lesions of patients with MALT lymphoma. ONCLUSION: (18)F-FDG PET contributes to the diagnosis of high-grade gastrointestinal non-Hodgkin's lymphoma, even when there is the normal background FDG activity. Furthermore, the SUV plays a role in evaluating treatment response. Low-grade NHL demonstrates FDG uptake but at a lesser intensity than seen in high-grade NHL.

Whole-body lymphoscintigraphy using transmission scans.

OBJECTIVE: Our objective was to show the advantages of performing whole-body lymphoscintigraphy using transmission sources. This technique should decrease scanning time, help locate the sentinel lymph node, and decrease radiation exposure to the technologist. METHODS: Twenty patients with proven melanoma received 18.5 MBq (0.5 mCi) filtered (0.22 microm) (99m)Tc-sulfur colloid in a 0.2-mL volume, administered as multiple intradermal or subcutaneous injections around the known melanoma lesion or scar. All 20 patients underwent serial static imaging immediately after the injection, along with whole-body scanning after the static imaging. The static emission images were acquired for 5 min and the transmission images for 1 min using a 256 x 256 matrix. The whole-body transmission scans were acquired after the whole-body emission scans. The transmission scans were obtained with the same parameters as the emission scans, with the addition of placement of a (57)Co sheet source on one of the detectors of the large-field-of-view dual-head camera. The planar static axial images (transmission, emission) were compared with the whole-body images (transmission, emission) to determine whether the same number of lymph nodes was visualized with each technique. Posterior outlines were obtained through computer manipulation of anterior transmission images. RESULTS: In all 20 patients, the number of lymph nodes seen on the static images was the same as that seen on the whole-body emission and transmission images. The whole-body emission and transmission scanning time was an average of 30 min less than the time required to acquire the serial static images. CONCLUSION: The anatomic location of the sentinel lymph node is seen more easily on whole-body images, both anterior transmission and posterior transmission, than on planar static images. Whole-body emission and transmission imaging decreased scanning time and thus improved patient comfort and throughput. Technologists received less radiation exposure when handling the (57)Co source only twice during whole-body imaging, as opposed to several times during static imaging.