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Life Sci ; 295: 120404, 2022 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-35176278

RESUMO

AIMS: Plastic particles (PP) pollution is a global environmental concern. Although the reproductive toxicity of PP is primarily understood for invertebrates, the evidence for mammals is still fragmented. We used a systematic review framework to investigate the reproductive impact of microplastics and nanoplastics (MNP) on mammals. MATERIALS AND METHODS: Research records were screened from Embase, Medline, Scopus and Web of Science. Twelve original papers were identified and reviewed. Immunological, oxidative and morphofunctional outcomes, and the risk of bias in all studies reviewed were analyzed. KEY FINDINGS: These studies indicated that PP can accumulate in the gonads, triggering seminiferous degeneration, Sertoli cells death, blood-testis barrier disruption, sperm degeneration, malformation, reduced number and mobility, ovarian cysts, reduced follicular growth and granulosa cells death. Gonadal damage was associated with upregulation of prooxidant mediators (oxygen reactive species, lipid and DNA oxidation), cell death, proinflammatory molecular pathways and cytokines, as well as inhibition of enzymatic and non-enzymatic antioxidant defense mechanisms. Spermatogenesis, folliculogenesis, testosterone, progesterone and estrogen levels were also impaired in PP-treated animals, which were potentially associated with down-regulation of molecules involved in germ cells microstructural organization (occludin, N-cadherin, ß-catenin and connexin 43) and steroidogenesis, such as hydroxysteroid dehydrogenases, steroidogenic acute regulatory proteins, follicle stimulating and luteinizing hormones. Selection, performance and detection bias were the main limitations identified. SIGNIFICANCE: Current evidence indicates that PP can induce dose-dependent microstructural and functional gonadal damage, which is orchestrated by pro-oxidant and pro-inflammatory mechanisms that disrupt genes, molecular effectors, and hormones that control spermatogenesis and folliculogenesis.


Assuntos
Genitália/efeitos dos fármacos , Microplásticos/efeitos adversos , Reprodução/efeitos dos fármacos , Animais , Estrogênios , Feminino , Células Germinativas/efeitos dos fármacos , Células da Granulosa/metabolismo , Inflamação , Mucosa Intestinal/efeitos dos fármacos , Hormônio Luteinizante , Masculino , Mamíferos/metabolismo , Mamíferos/fisiologia , Folículo Ovariano/metabolismo , Ovário , Estresse Oxidativo , Plásticos/efeitos adversos , Progesterona , Células de Sertoli/metabolismo , Espermatogênese , Testículo , Testosterona
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