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1.
Pediatr Dermatol ; 2024 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-39235105

RESUMO

A 13-year-old male presented with a 2-year history of recurrent aphthous stomatitis. The patient had undergone several unsuccessful treatments, leading to the decision to initiate apremilast. He showed a good clinical response with reduction in outbreaks, and no adverse effects were observed. This is the first report, to our knowledge, of a pediatric patient treated with apremilast for this indication.

3.
Pediatr Dermatol ; 41(4): 680-683, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38342575

RESUMO

An 11-year-old boy presented generalized eruptive syringomas (ESs) associated with multiple milia-like whitish palmar papules corresponding to dermal calcium deposits. A relationship between calcium deposits distribution to an underlying eccrine duct was noted on pathology. The observation of dermal calcium deposits and its association with generalized ESs may support a possible sweat duct origin of this uncommon and peculiar form of superficial calcinosis cutis.


Assuntos
Calcinose , Neoplasias das Glândulas Sudoríparas , Siringoma , Humanos , Masculino , Calcinose/patologia , Calcinose/etiologia , Siringoma/patologia , Criança , Neoplasias das Glândulas Sudoríparas/patologia , Neoplasias das Glândulas Sudoríparas/complicações , Dermatopatias/patologia , Dermatopatias/etiologia , Calcinose Cutânea , Ceratose
5.
J Allergy Clin Immunol Pract ; 11(12): 3763-3771.e5, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-37716526

RESUMO

BACKGROUND: Autoimmunity contributes to the pathogenesis of chronic spontaneous urticaria (CSU). The subtyping of CSU has revealed an autoimmune form of CSU. Despite autoimmune diseases having been associated with CSU, there are few prospective studies that have evaluated the characteristics and biomarkers of patients with CSU and autoimmune disease in a real-life practice setting. OBJECTIVE: To evaluate the presence of specific biomarkers for the presence of autoimmune disease in CSU and to analyze the clinical and therapeutic features of patients with CSU and autoimmune disease. METHODS: The clinical, laboratory, and therapeutic features of patients with CSU at a tertiary-level center were prospectively collected. Data obtained were compared in function of the presence/absence of autoimmune disease and typified according to IgE levels. RESULTS: Patients with CSU who had associated autoimmune disease corresponded to middle-aged women with a common pattern of blood test findings: both low baseline IgE and high-affinity receptor of IgE expression, basopenia, eosinopenia, higher baseline erythrocyte sedimentation rate and D-dimer, increased presence of antinuclear antibodies, IgG against thyroid peroxidase, and positive autologous serum skin test result. Total baseline IgE less than or equal to 43.8 IU/mL was both the optimal cutoff to predict autoimmune disease in the CSU cohort and a significant risk factor for the presence of autoimmune disease in the regression analysis. CONCLUSIONS: In real-life clinical practice, characteristics of patients with CSU and autoimmune disease share common features with type IIb autoimmune CSU. Total baseline IgE less than or equal to 43.8 IU/mL has been detected as a possible biomarker of autoimmune disease in patients with CSU.


Assuntos
Doenças Autoimunes , Urticária Crônica , Urticária , Pessoa de Meia-Idade , Humanos , Feminino , Estudos Prospectivos , Autoanticorpos , Biomarcadores , Imunoglobulina E , Doença Crônica , Urticária/etiologia
6.
Am J Dermatopathol ; 45(9): 646-649, 2023 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-37506270

RESUMO

ABSTRACT: Xanthelasma palpebrarum represent the most common subtype of cutaneous plane xanthomas. Xanthosiderohistiocytosis is considered a rare variant of xanthoma disseminatum, with only 4 cases reported to date. We report the case of a man with progressive pigmented lesions on the 4 eyelids that could correspond to hemosiderotic xanthelasmas or a localized variant of xanthosiderohistiocytosis.


Assuntos
Doenças do Tecido Conjuntivo , Doenças Palpebrais , Hemossiderose , Neoplasias Cutâneas , Xantomatose , Masculino , Humanos , Doenças Palpebrais/patologia , Pálpebras , Xantomatose/patologia
11.
Dermatol Ther ; 35(11): e15806, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36070222

RESUMO

Extensive subtypes of alopecia areata (AA) (totalis, universalis, or multifocal) still have no approved and effective treatments in Europe, although Janus kinase inhibitors, such as baricitinib, are promising treatments that have been recently approved by the FDA. Nowadays, the higher costs and the lower experience with Janus kinase inhibitors, provide more difficulties in its accessibility. On the other hand, different corticosteroids regimens have been evaluated with conflicting results from decades. In 2016, a new regimen of mini pulse corticosteroid therapy with oral dexamethasone (MPCT-OD) 0.1mg/kg/day twice per week for adult patients with alopecia areata totalis or universalis, was reported to be effective with a lower rate of adverse effects. We performed a retrospective and multicentric study to collect data from patients with extensive forms of alopecia areata who had received MPCTOD (0.1 mg/kg/day twice weekly of dexamethasone) for at least 24 weeks. We included adult patients (≥18 years) with extensive forms of AA (SALT index ≥ 10) that did not respond to previous treatments. Variables including epidemiological and clinical data were recorded. Therapeutic response was assessed through the % change in SALT score (from 0 to 100%) and the changes in eyebrow and eyelash alopecia index (EBA, ELA) from baseline to 24 weeks after the beginning of the treatment. Dexamethasone dosage, duration of the treatment, time until response, time to relapse, adverse effects, and discontinuation were also recorded.


Assuntos
Alopecia em Áreas , Inibidores de Janus Quinases , Adulto , Humanos , Alopecia em Áreas/diagnóstico , Alopecia em Áreas/tratamento farmacológico , Alopecia em Áreas/induzido quimicamente , Inibidores de Janus Quinases/efeitos adversos , Estudos Retrospectivos , Dexametasona/efeitos adversos , Alopecia/tratamento farmacológico , Resultado do Tratamento , Corticosteroides/uso terapêutico
14.
Clin Exp Dermatol ; 47(6): 1207-1209, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35342976

RESUMO

We describe a patient with unilateral ulcerations on the forehead and scalp, occurring 3 months after herpes zoster infection. Further investigations were unremarkable. Histology showed epidermal and upper dermal ulceration associated with a mild nonspecific dermal inflammatory infiltrate composed of lymphoid cells and histiocytes.


Assuntos
Herpes Zoster , Couro Cabeludo , Testa , Herpes Zoster/complicações , Herpes Zoster/diagnóstico , Histiócitos , Humanos
15.
Australas J Dermatol ; 63(1): e49-e51, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34905624

RESUMO

A 57-year-old woman presenting an acquired and persisting palmoplantar keratoderma associated with primary biliary cholangitis is reported. Treatment with oral ursodeoxycholic acid was prescribed, and a complete and persistent resolution of skin lesions was noted. This observation seems to support that acquired palmoplantar keratoderma is an uncommon cutaneous manifestation of primary biliary cholangitis.


Assuntos
Colagogos e Coleréticos/uso terapêutico , Ceratodermia Palmar e Plantar/tratamento farmacológico , Cirrose Hepática Biliar/tratamento farmacológico , Ácido Ursodesoxicólico/uso terapêutico , Feminino , Humanos , Ceratodermia Palmar e Plantar/etiologia , Cirrose Hepática Biliar/complicações , Pessoa de Meia-Idade
16.
Contact Dermatitis ; 85(6): 679-685, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34291473

RESUMO

BACKGROUND: Different textile constituents may act as allergens and/or irritants and provoke textile contact dermatitis (TCD). OBJECTIVES: To report a case of TCD caused by ethylene glycol monododecyl ether and 2,4-dichlorophenol, present in a bikini. METHODS: A woman presented with an eczematous, pruritic rash in the area of the bikini straps and back. Patch testing was performed with the European baseline, textile, sunscreen, and photo-patch series, the bikini "as is", and ethanol and acetone extracts of the bikini. Thin-layer chromatography (TLC) of the extracts and gas chromatography-mass spectrometry (GC-MS) analysis were used to elucidate the culprit agents. RESULTS: Positive reactions were found to the bikini "as is" and to the ethanol and acetone extracts. Patch testing with TLC strips showed a strong reaction to spots-fractions 3 and 4. GC-MS was performed to identify substances in each fraction and those suspected to be skin sensitisers were patch tested. On day (D) 4 positive reactions to ethylene glycol monododecyl ether (irritant reaction) and 2,4-dichlorophenol (++) were observed. CONCLUSION: A myriad of chemical compounds can be found in clothing. Ethylene glycol monododecyl ether and 2,4-dichlorophenol were identified as the potential culprits of this bikini TCD.


Assuntos
Clorofenóis/efeitos adversos , Vestuário/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Polidocanol/efeitos adversos , Têxteis/efeitos adversos , Clorofenóis/análise , Dermatite Alérgica de Contato/diagnóstico , Feminino , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Pessoa de Meia-Idade , Testes do Emplastro , Polidocanol/análise , Têxteis/análise
20.
Acta Derm Venereol ; 99(12): 1071-1077, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31408184

RESUMO

Acquired cold urticaria (ACU) is characterized by the development of itchy wheals after cold exposure. Generalized urticarial skin rashes triggered by cold exposure characterize certain monogenic autoinflammatory diseases (AIDs). The objective of this study is to investigate the presence of variants in genes causing AIDs that present with cold-induced urticarial skin rashes in patients clinically diagnosed with ACU, in order to look for susceptibility factors for the disease. Fifty patients with primary ACU were studied. Germline and post-zygotic variants on the NLRP3, NLRP12, NLRC4 and PLCG2 genes were investigated using next-generation sequencing technology. Seven patients (14%) carried 8 heterozygous germline variants in the following genes: NLRP3 (n = 1), NLRP12 (n = 3), NLRC4 (n = 1), PLCG2 (n = 3). No pathogenic or likely pathogenic variants were detected, and deep analyses of the sequences obtained did not identify any post-zygotic variant. In conclusion, ACU is not related to post-zygotic or germline pathogenic variants in the NLRP3, NLRP12, NLRC4 and PLCG2 genes.


Assuntos
Temperatura Baixa/efeitos adversos , Variação Genética , Doenças Hereditárias Autoinflamatórias/genética , Urticária/genética , Adolescente , Adulto , Idoso , Proteínas Adaptadoras de Sinalização CARD/genética , Proteínas de Ligação ao Cálcio/genética , Criança , Pré-Escolar , Feminino , Predisposição Genética para Doença , Doenças Hereditárias Autoinflamatórias/diagnóstico , Doenças Hereditárias Autoinflamatórias/imunologia , Humanos , Lactente , Peptídeos e Proteínas de Sinalização Intracelular/genética , Masculino , Pessoa de Meia-Idade , Proteína 3 que Contém Domínio de Pirina da Família NLR/genética , Fenótipo , Fosfolipase C gama/genética , Estudos Prospectivos , Fatores de Risco , Espanha , Centros de Atenção Terciária , Urticária/diagnóstico , Urticária/imunologia , Adulto Jovem
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