Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game.

Aerobic glycolysis, also known as the Warburg effect, has for a prolonged period of time been perceived as a defining feature of tumor metabolism. The redirection of glucose utilization towards increased production of lactate by cancer cells enables their rapid proliferation, unceasing growth, and longevity. At the same time, it serves as a significant contributor to acidification of the tumor microenvironment, which, in turn, imposes substantial constraints on infiltrating immune cells. Here, we delve into the influence of tumor-derived lactic acid on innate lymphoid cells (ILCs) and discuss potential therapeutic approaches. Given the abundance of ILCs in barrier tissues such as the skin, we provide insights aimed at translating this knowledge into therapies that may specifically target skin cancer.

The Psychological Well-Being and Civic Engagement of Polish, Croatian and Lithuanian Academic Students during COVID-19 Outbreak.

The aim of this research was to recognize the relationship between well-being and civic engagement under the difficult circumstances of the COVID-19 pandemic amongst students from Poland, Lithuania and Croatia. Overall, 1362 academic students (Poland, n = 596, Croatia, n = 386, and Lithuania, n = 379) participated in the study. Mean rank differences in civic engagement level (overall CE) were analysed by levels of psychological well-being (overall PWB and its subscales) using the Kruskal-Wallis test (one-way ANOVA on ranks). We conducted post hoc analysis with Bonferroni tests to measure the significance of differences in CE between the detailed levels of PWB. To avoid biases due to interaction effects between dependent variables, the analysis of mean ranks was followed by a binomial logistic regression analysis model and subgroups analysis (by gender and by country). Results obtained showed that students with higher levels of psychological well-being have higher levels of civic engagement. The differences in the CE level are most pronounced in relation to the dimension of a PWB, such as "positive relations with others", followed by "personal growth", "autonomy", and "self-acceptance". In a crisis, such as a pandemic, it is worth encouraging students to take targeted actions, as well as to create actions referring to personal development and relationships. There were no differences in the direction and shape of the associations between psychological well-being and civic engagement with respect to the country and the gender of the participants, which leads us to draw conclusions pointing to the globalised nature of student experience during the pandemic in this part of Europe.

Assessment of Physical Well-Being and Leisure Time of Polish Students during the COVID-19 Outbreak.

This project aims to recognize the school experiences of Polish students during the COVID-19 outbreak; we focused on the area of assessment of physical well-being and leisure time. Nearly two thousand primary or secondary school students aged 9 to 20 participated in the survey. Running descriptive statistics, frequency analysis, and significant difference tests, we found that 45% of students thought their physical well-being during the COVID-19 outbreak worsened compared to pre-pandemic times. Boys declared they felt better in their physical well-being than girls (p < 0.001). Most students noticed changes in the quality of their leisure time activities; boys were happier than girls in their free time during the outbreak (p < 0.001). Learners' ages also differentiated the assessment of their physical well-being (p < 0.001) and leisure time (p < 0.001). The youngest students more often assessed their experiences in the researched fields as good or increased, while the older groups more often noticed a decrease. Multinomial logistic regression proved that the differences in the assessments of physical well-being and leisure time could be explained to the greatest extent by age and gender, whereas the place of residence and school location were insignificant. All in all, our study confirms the dominance of the adverse effects of the COVID-19 pandemic on physical well-being and changes in leisure time. As such, it is advisable (during and after outbreaks) to support children and adolescents by targeting individual and institution levels. We recommend developing techniques to reduce stress and information overload, increasing creative ways of spending leisure time, supporting families in navigating children's free time, and expanding social support networks.