Treatment of COVID-19 during the Acute Phase in Hospitalized Patients Decreases Post-Acute Sequelae of COVID-19.

BACKGROUND: The post-acute sequelae of SARS-CoV-2 (PASC) infection have caused a significant impact on our health system, but there is limited evidence of approved drugs focused on its prevention. Our objective was to identify risk factors that can determine the presence of PASC, with special attention to the treatment received in the acute phase, and to describe the profile of persistent symptoms in a multidisciplinary Post-Coronavirus Disease-19 (COVID-19) Unit. METHODS: This one-year prospective observational study included patients following an acute COVID-19 infection, irrespective of whether they required hospital admission. A standardized symptom questionnaire and blood sampling were performed at the first follow-up visit, and demographic and clinical electronic data were collected. We compared subjects with PASC with those who had fully recovered. Multivariate logistic regression was performed to identify factors associated with PASC in hospitalized patients, and Kaplan-Meier curves were used to assess duration of symptoms according to disease severity and treatments received in the acute phase. RESULTS: 1966 patients were evaluated; 1081 had mild disease, 542 moderate and 343 severe; around one third of the subjects had PASC, and were more frequently female, with obesity, asthma, and eosinophilia during acute COVID-19 disease. Patients who received treatment with dexamethasone and remdesivir during the course of the acute illness showed a lower median duration of symptoms, compared with those who received none of these treatments. CONCLUSION: Treatment with dexamethasone and/or remdesivir may be useful to reduce the impact of PASC secondary to SARS-CoV-2 infection. In addition, we identified female gender, obesity, asthma, and disease severity as risk factors for having PASC.

[Evaluation of patient satisfaction after stroke rehabilitation program. Validation study for the Spanish version of the Satisfaction Pound Scale]. / Evaluación de la satisfacción con el programa de rehabilitación tras el ictus: validación de la versión española de la Pound Satisfaction Scale.

BACKGROUND AND OBJECTIVE: The Satisfaction Pound Scale is a specific questionnaire to evaluate satisfaction with the rehabilitation program after a stroke. The aim of this study was to adapt this scale to Spanish and to evaluate its metric characteristics. METHOD: The adaptation included translation and back-translation methods. Metric characteristics were evaluated in 74 patients, all of whom were administered the Satisfaction Pound Scale and the Short Form 36 (SF-36). The statistical model was tested by confirmatory factor analysis (CFA). Reliability was determined through Cronbach alpha coefficient and a test-retest procedure. Construct validity was assessed by means of correlations between the satisfaction scale and the SF-36. RESULTS: Adjustment indicators in the CFA were very good. Reproducibility test showed correlations higher than 0.85, and all correlations between SF-36 dimensions and the satisfaction scale were lower than 0.2, in accordance with the hypotheses raised. CONCLUSIONS: The Spanish version of the Satisfaction Pounds Scale is reliable and valid, therefore it is a useful tool to assess satisfaction with the post-stroke rehabilitation program in our area.

Evaluación de la satisfacción con el programa de rehabilitación tras el ictus: validación de la versión española de la Pound Satisfaction Scale / Evaluation of patient satisfaction after stroke rehabilitation program. Validation study for the Spanish version of the Satisfaction Pound Scale

Fundamento y objetivo. La Escala de Satisfacción de Pound es un cuestionario específico para evaluar la satisfacción con la rehabilitación seguida tras el ictus. Nuestro objetivo fue adaptar esta escala al español y evaluar sus características métricas. Método. La adaptación se realizó por traducción-retrotraducción. Las características métricas se evaluaron en 74 pacientes con la Escala de Satisfacción de Pound y el cuestionario de salud percibida Short Form 36 (SF-36). El modelo de medida se evaluó mediante análisis factorial confirmatorio (AFC); la fiabilidad, a partir de la consistencia interna y la reproducibilidad (test-retest); la validez de constructo se estudió mediante las correlaciones entre la escala de Pound y el SF-36. Resultados. Los indicadores de bondad de ajuste del AFC fueron muy buenos. En el estudio test-retest los coeficientes de correlación intraclase fueron>0,85. Todas las correlaciones entre las dimensiones del SF-36 y el cuestionario de satisfacción fueron<0,2. Conclusiones. La versión en español de la Escala de Satisfacción de Pound administrada telefónicamente es fiable y válida, resultando útil para evaluar la satisfacción con la rehabilitación seguida tras el ictus (AU)

Background and objective. The Satisfaction Pound Scale is a specific questionnaire to evaluate satisfaction with the rehabilitation program after a stroke. The aim of this study was to adapt this scale to Spanish and to evaluate its metric characteristics. Method. The adaptation included translation and back-translation methods. Metric characteristics were evaluated in 74 patients, all of whom were administered the Satisfaction Pound Scale and the Short Form 36 (SF-36). The statistical model was tested by confirmatory factor analysis (CFA). Reliability was determined through Cronbach alpha coefficient and a test-retest procedure. Construct validity was assessed by means of correlations between the satisfaction scale and the SF-36. Results. Adjustment indicators in the CFA were very good. Reproducibility test showed correlations higher than 0.85, and all correlations between SF-36 dimensions and the satisfaction scale were lower than 0.2, in accordance with the hypotheses raised. Conclusions. The Spanish version of the Satisfaction Pounds Scale is reliable and valid, therefore it is a useful tool to assess satisfaction with the post-stroke rehabilitation program in our area (AU)

Validación de la versión española del Functional Assessment of Cancer Therapy Questionnaire for Breast Cancer (FACT-B+4) / Functional Assessment of Cancer Therapy Questionnaire for Breast Cancer (FACT-B+4). Spanish version validation

Fundamento y objetivos: Evaluar la aceptabilidad, fiabilidad, validez y sensibilidad al cambio de la versión en español del cuestionario FACT-B+4 para evaluar la calidad de vida relacionada con la salud (CVRS) en cáncer de mama.Pacientes y métodos: Estudio prospectivo con 2 muestras: pacientes con cáncer de mama incidente (n=104) evaluadas antes y después de la cirugía; y pacientes con linfedema crónico de la extremidad superior (n=30) evaluadas dos veces en 7 días. La CVRS se evaluó mediante el SF-36 y el FACT-B+4. Resultados: Los coeficientes de fiabilidad fueron ≥ 0,7 para la mayoría de las puntuaciones. Las puntuaciones de Bienestar Físico, Cáncer de Mama, Extremidad Superior y TOI discriminaron entre pacientes con y sin quimioterapia (p<0,05), mientras que la escala de Extremidad Superior discriminó entre pacientes con y sin linfadenectomía (p<0,001). En la submuestra de empeoramiento, el FACT-B+4 detectó cambios en Bienestar Físico, Emocional, Funcional, Extremidad Superior y en el sumario TOI. Conclusiones: Las características métricas de la versión española del FACT-B+4 son similares a las del cuestionario original y apoyan su equivalencia, avalando su idoneidad para ser utilizado en nuestro país o en estudios internacionales

Background and objectives: To evaluate the acceptability, reliability, validity, and sensitivity to change of the Spanish version of the FACT-B+4 questionnaire, designed to assess the health related quality of life (HRQL) in breast cancer. Patients and methods: Prospective study with 2 samples: patients with incident breast cancer (n=104) evaluated before and after surgery; and patients with chronic lymphedema of the upper extremity (n=30), evaluated twice in 7days. HRQL was assessed using the generic instrument SF-36 and the specific one FACT-B+4. Results: Reliability coefficients were ≥ 0.7 for most scores. The Physical wellbeing, Breast Cancer, Arm and TOI scores discriminated between patients with and without chemotherapy (p<0.05), while the Arm scale discriminated between patients with and without axillary surgery (p<0.001). In the worsening sub-sample, the FACT-B+4 detected changes in Physical, Emotional and Functional Wellbeing, and TOI scores. Conclusions: The metric characteristics of the Spanish version of the FACT-B+4 are similar to the original questionnaire and support its equivalence, documenting its suitability for use in our country or in international studies

[Functional Assessment of Cancer Therapy Questionnaire for Breast Cancer (FACT-B+4). Spanish version validation]. / Validación de la versión española del Functional Assessment of Cancer Therapy Questionnaire for Breast Cancer (FACT-B+4).

BACKGROUND AND OBJECTIVES: To evaluate the acceptability, reliability, validity, and sensitivity to change of the Spanish version of the FACT-B+4 questionnaire, designed to assess the health related quality of life (HRQL) in breast cancer. PATIENTS AND METHODS: Prospective study with 2 samples: patients with incident breast cancer (n=104) evaluated before and after surgery; and patients with chronic lymphedema of the upper extremity (n=30), evaluated twice in 7days. HRQL was assessed using the generic instrument SF-36 and the specific one FACT-B+4. RESULTS: Reliability coefficients were ≥ 0.7 for most scores. The Physical wellbeing, Breast Cancer, Arm and TOI scores discriminated between patients with and without chemotherapy (p<0.05), while the Arm scale discriminated between patients with and without axillary surgery (p<0.001). In the worsening sub-sample, the FACT-B+4 detected changes in Physical, Emotional and Functional Wellbeing, and TOI scores. CONCLUSIONS: The metric characteristics of the Spanish version of the FACT-B+4 are similar to the original questionnaire and support its equivalence, documenting its suitability for use in our country or in international studies.