RESUMO
Solitary fibrous tumor (SFT) is a rare type of mesenchymal lesion with variable clinical presentation in which specific clinicopathologic factors have been related to patient outcome. SFT shares an important morphologic and immunohistochemical overlap with other sarcomas, hence the differential diagnosis is challenging. Although molecular studies provide significant clues, especially in the differential diagnosis with other neoplasms, a thorough hematoxylin and eosin analysis and the integration of phenotypical, clinical, and radiological features remain an essential tool in SFT diagnosis. In this review, we discuss some emerging issues still under debate in SFT.
Assuntos
Hemangiopericitoma , Lagartos , Neoplasias Meníngeas , Neoplasias de Tecidos Moles , Tumores Fibrosos Solitários , Humanos , Animais , Tumores Fibrosos Solitários/diagnóstico , Tumores Fibrosos Solitários/genética , Tumores Fibrosos Solitários/patologia , Hemangiopericitoma/diagnóstico , Hemangiopericitoma/patologia , Medição de Risco , Neoplasias de Tecidos Moles/diagnóstico , Diagnóstico DiferencialRESUMO
Langerhans cell histiocytosis (LCH) is a heterogeneous disease characterized by proliferation of Langerhans cells and BRAF mutation in almost half of the cases. Bone involvement is common but large soft tissue disease is uncommon. We report a pediatric patient with a large tumor mass involving the left iliac bone and the adjacent soft tissue. The computed tomography scan showed an osteolytic lesion with soft tissue extension. Surgical curettage of the lesion was performed and the final histopathologic diagnosis was LCH with CD1a immunoreactivity in tumor cells. The molecular analysis revealed a BRAF V600E mutation. We discuss the histopathological and immunohistochemical differential diagnosis with histiocytosis other than LCH.
Assuntos
Doenças Ósseas , Células Gigantes/patologia , Histiocitose de Células de Langerhans , Mutação , Proteínas Proto-Oncogênicas B-raf/genética , Neoplasias de Tecidos Moles , Doenças Ósseas/diagnóstico por imagem , Doenças Ósseas/genética , Doenças Ósseas/patologia , Pré-Escolar , Feminino , Histiocitose de Células de Langerhans/diagnóstico por imagem , Histiocitose de Células de Langerhans/genética , Histiocitose de Células de Langerhans/patologia , Humanos , Ílio/diagnóstico por imagem , Ílio/patologia , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/genética , Neoplasias de Tecidos Moles/patologia , Tomografia Computadorizada por Raios XRESUMO
Con el siguiente artículo los autores pretenden describir las diferentes manifestaciones clínicas que pueden aparecer en la extremidad inferior, con especial atención al pie, en pacientes de lepra en todas sus formas clínicas, tanto activos como de alta terapéutica con secuelas secundarias a la enfermedad. Se describen las manifestaciones dermatológicas, neurológicas, las alteraciones tróficas, óseas y radiológicas presentes en pacientes controlados en el Sanatorio de Fontilles. Se expone la forma actual de trabajo en el campo, con la clasificación de los pacientes en Paucibacilares y Multibacilares, el tratamiento específico de la enfermedad y los cuidados locales a realizar (AU)
