RESUMO
The case of a 19-year-old epileptic man with a solitary hepatic adenoma is described. The tumor was 9 x 8.5 x 6.5 cm in size and microscopically consisted of cells similar in appearance to non-neoplastic hepatocytes, arranged in cords with slit-like sinusoids interposed. Bile ducts and portal tracts were conspicuously absent. Our patient was on antiepileptic drugs, among them phenobarbital which experimentally produces liver cell tumors in mice and rats.
Assuntos
Barbitúricos/efeitos adversos , Carcinoma Hepatocelular/induzido quimicamente , Epilepsia/tratamento farmacológico , Neoplasias Hepáticas/induzido quimicamente , Adulto , Barbitúricos/uso terapêutico , Carcinoma Hepatocelular/patologia , Humanos , Neoplasias Hepáticas/patologia , MasculinoRESUMO
A case of dystrophic calcification of the myocardium in the transplanted heart of a 34-year-old man is presented. The calcification appeared immediately after transplantation with massive progression until the thirty-fifth day when the patient died. Pulmonary hypertension, cardiac surgery, administration of steroids and calcium chloride, in addition to transitory acute renal failure may be the multicausal factors that produced this myocardial calcification.
Assuntos
Calcinose/etiologia , Cardiomiopatias/etiologia , Transplante de Coração , Transplante Homólogo/efeitos adversos , Adulto , Calcinose/patologia , Cardiomegalia/etiologia , Cardiomiopatias/patologia , Humanos , Hipertensão Pulmonar/etiologia , Masculino , Miocárdio/patologiaRESUMO
Two patients developed non-Hodgkin's lymphoma (NHL) six and ten years after radiotherapy and chemotherapy for Hodgkin's disease nodular sclerosis type. The histological classification of the developing NHL for the two patients was: IgG (K) secreting lymphoplasmacytoid lymphoma of the stomach, and immunoblastic lymphoma of the cervical lymph nodes. Both patients responded well to conventional chemotherapy for NHL and are alive 22 and 5 months after the diagnosis of the secondary tumor. Forty eight cases of NHL after treatment for HD have been previously reported. We present a review of the literature of these cases, adding to this literature the first reported case of gastric lymphoplasmacytoid lymphoma under such circumstances.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Neoplasias de Cabeça e Pescoço/etiologia , Doença de Hodgkin/complicações , Leucemia Linfocítica Crônica de Células B/etiologia , Linfoma Imunoblástico de Células Grandes/etiologia , Radioterapia/efeitos adversos , Neoplasias Gástricas/etiologia , Adolescente , Ciclofosfamida/administração & dosagem , Doxorrubicina/administração & dosagem , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Neoplasias de Cabeça e Pescoço/patologia , Doença de Hodgkin/patologia , Doença de Hodgkin/terapia , Humanos , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Leucemia Linfocítica Crônica de Células B/patologia , Linfoma Imunoblástico de Células Grandes/tratamento farmacológico , Linfoma Imunoblástico de Células Grandes/patologia , Masculino , Pessoa de Meia-Idade , Prednisona/administração & dosagem , Neoplasias Gástricas/tratamento farmacológico , Neoplasias Gástricas/patologia , Vincristina/administração & dosagemRESUMO
In order to determine the value of an isolated renal percutaneous biopsy in renal allografts with acute rejection, we studied 17 allograft nephrectomies, in which the histological degree of acute rejection of each of 30 Tru-cut cylinders, were compared with the histological degree of acute rejection diagnosed in 6 large fragments of each kidney considered as a whole. An accurate histological degree of acute rejection was made in 366 cylinders (71.8%). One hundred twenty-nine kidney cylinders (25.3%) were considered of a minor histological degree of acute rejection and 15 cylinders (2.9%) of a higher histological degree. We conclude that percutaneous renal allograft biopsy provides a representative picture of acute rejection histopathology but must be evaluated with other clinical and biochemical data for a correct clinical management.
Assuntos
Biópsia , Rejeição de Enxerto , Rim/patologia , Doença Aguda , Adulto , Feminino , Humanos , Transplante de Rim , Masculino , Pessoa de Meia-Idade , Nefrectomia , Complicações Pós-Operatórias/diagnóstico , PrognósticoAssuntos
Gastrite Hipertrófica/patologia , Gastrite/patologia , Adulto , Idoso , Biópsia , Feminino , Gastroscopia , Humanos , Masculino , Pessoa de Meia-Idade , Estômago/patologiaRESUMO
This is a case report of a 44-year-old man with a chordoma of the clivus that caused dysphonia, low back pain, and urinary and fecal incontinence. The diagnosis was made by cytologic study of the CSF, which demonstrated vacuolated malignant cells. The patient was treated with intrathecal methotrexate, dexamethasone, and radiotherapy. At autopsy extensive dissemination of chordoma was found at the base of the brain, in the ventricles, and in the leptomeninges of the spinal cord. This is the sixth reported case of intrathecal dissemination of a chordoma and the first diagnosed by cytology of the cerebrospinal fluid.
