RESUMO
The influence of melatonin application on wounds healing and biochemical composition of rat regenerating granulation tissue was studied. Melatonin decreased healing rate of wounds. The differences in electrophoretic pattern of proteins extracted by neutral saline solutions were detected. Melatonin increased quantity of neutral soluble collagen fraction and gene expression of minor types of collagen in normal skin. Spectrum of glycosaminoglycans' was changed, and earlier increase of chondroitinsulfats induced by administration of melatonin was observed.
Assuntos
Tecido de Granulação/efeitos dos fármacos , Melatonina/farmacologia , Cicatrização/efeitos dos fármacos , Animais , Cromatografia por Troca Iônica , Eletroforese em Gel Bidimensional , Glicosaminoglicanos/metabolismo , Tecido de Granulação/metabolismo , Masculino , Ratos , Ratos WistarAssuntos
Glicosaminoglicanos/metabolismo , Pele/metabolismo , Estresse Psicológico/metabolismo , Animais , Imersão , Masculino , Ratos , Ratos WistarRESUMO
The clinical manifestations of clonorchiasis were studied in 190 patients in the Amur River region. The severity of the disease correlated with the excretion rates of Clonorchis eggs. The peculiarity of the region is a rather low egg excretion; 66.8% of patients excreted as many as 100 eggs/g, 27.3%, up to 1000 eggs/g. Most examinees (94.3%) suffered from chronic gastroduodenitis and functional disorders of the biliary system.