RESUMO
Non-steroidal, anti-inflammatory agents (NSAIDs), wellknown inhibitors of prostaglandins, have been used in the treatment of biliary and ureteral pain since the end of the 1970s. The efficacy and tolerance of a new injectable formulation of naproxen sodium in ureteral and biliary pain was investigated in 77 out-patients, observed in an emergency ward, and affected by acute lithiasic symptomatology. Forty-four patients received one 275 mg vial of naproxen sodium intramuscularly, while 33 patients were given one vial at the same dosage intravenously. In 56% of the cases complete relief of pain was achieved within 30 minutes of injection, while in 86% pain was completely relieved or greatly decreased within one hour. Side-effects (nausea, vomiting) occurred in three patients, but were linked to a simultaneous aggravation of the ureteral colic.
Assuntos
Doenças Biliares/fisiopatologia , Naproxeno/uso terapêutico , Dor/tratamento farmacológico , Doenças Ureterais/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Infusões Parenterais , Masculino , Pessoa de Meia-Idade , Naproxeno/administração & dosagem , Naproxeno/efeitos adversos , Náusea/induzido quimicamente , Fatores de Tempo , Vômito/induzido quimicamenteAssuntos
Heparina/uso terapêutico , Tromboembolia/tratamento farmacológico , Adolescente , Adulto , Ensaios Clínicos como Assunto , Método Duplo-Cego , Avaliação de Medicamentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tempo de Tromboplastina Parcial , Tromboembolia/prevenção & controleAssuntos
Acetildigoxinas/uso terapêutico , Digoxina/análogos & derivados , Cardiopatias/tratamento farmacológico , Adulto , Idoso , Cálcio/sangue , Ensaios Clínicos como Assunto , Digoxina/sangue , Feminino , Cardiopatias/sangue , Humanos , Masculino , Medigoxina/uso terapêutico , Pessoa de Meia-Idade , Potássio/sangueAssuntos
Pressão Sanguínea/efeitos dos fármacos , Bupranolol/farmacologia , Propanolaminas/farmacologia , Taquicardia/tratamento farmacológico , Adolescente , Adulto , Idoso , Ensaios Clínicos como Assunto , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
105 patients with either biliary colics (54) or ureteral colics (51) were treated with rociverine, a new antispastic drug, at a dose of 20 mg iv. The drug showed a rapid and effective spasmolytic activity (total disappearance of painful symptoms in 89% of patients with biliary colic and in 92% of patients with ureteral colic).
Assuntos
Compostos Bicíclicos com Pontes/uso terapêutico , Hidrocarbonetos Aromáticos com Pontes/uso terapêutico , Ácidos Cicloexanocarboxílicos , Dor/tratamento farmacológico , Parassimpatolíticos/uso terapêutico , Adolescente , Adulto , Idoso , Doenças Biliares/tratamento farmacológico , Cólica , Feminino , Humanos , Nefropatias/tratamento farmacológico , Masculino , Pessoa de Meia-IdadeRESUMO
A study was carried out to investigate the analgesic effect of an injectable salt of indomethacin - methylglucamine indomethacinate - in patients with acute ureteral and biliary pain. Out of 106 consecutive patients treated by the intramuscular (average dose 72.6 mg) or intravenous (average dose 36.1 mg) route, 76 (71.6%) had complete relief of pain and 4 were remarkably improved. In 68.8% of the cases, complete relief was reached within 1 hour from the start of treatment. No important side-effects were observed. Headache, nausea and drowsiness were reported in a few cases.