Resembling Graphene/Polymer Aerogel Morphology for Advancing the CO2/N2 Selectivity of the Postcombustion CO2 Capture Process.

The separation of CO2 from N2 remains a highly challenging task in postcombustion CO2 capture processes, primarily due to the relatively low CO2 content (3-15%) compared to that of N2 (70%). This challenge is particularly prominent for carbon-based adsorbents that exhibit relatively low selectivity. In this study, we present a successfully implemented strategy to enhance the selectivity of composite aerogels made of reduced graphene oxide (rGO) and functionalized polymer particles. Considering that the CO2/N2 selectivity of the aerogels is affected on the one hand by the surface chemistry (offering more sites for CO2 capture) and fine-tuned microporosity (offering molecular sieve effect), both of these parameters were affected in situ during the synthesis process. The resulting aerogels exhibit improved CO2 adsorption capacity and a significant reduction in N2 adsorption at a temperature of 25 °C and 1 atm, leading to a more than 10-fold increase in selectivity compared to the reference material. This achievement represents the highest selectivity reported thus far for carbon-based adsorbents. Detailed characterization of the aerogel surfaces has revealed an increase in the quantity of surface oxygen functional groups, as well as an augmentation in the fractions of micropores (<2 nm) and small mesopores (<5 nm) as a result of the modified synthesis methodology. Additionally, it was found that the surface morphology of the aerogels has undergone important changes. The reference materials feature a surface rich in curved wrinkles with an approximate diameter of 100 nm, resulting in a selectivity range of 50-100. In contrast, the novel aerogels exhibit a higher degree of oxidation, rendering them stiffer and less elastic, resembling crumpled paper morphology. This transformation, along with the improved functionalization and augmented microporosity in the altered aerogels, has rendered the aerogels almost completely N2-phobic, with selectivity values ranging from 470 to 621. This finding provides experimental evidence for the theoretically predicted relationship between the elasticity of graphene-based adsorbents and their CO2/N2 selectivity performance. It introduces a new perspective on the issue of N2-phobicity. The outstanding performance achieved, including a CO2 adsorption capacity of nearly 2 mmol/g and the highest selectivity of 620, positions these composites as highly promising materials in the field of carbon capture and sequestration (CCS) postcombustion technology.

Physiotherapy in palliative medicine: patient and caregiver wellness.

OBJECTIVES: Despite the demonstrated efficacy of physiotherapy in palliative care programmes, there are scarce data of its real-life impact on patients' and caregivers' wellness and stress. Our aim was to assess effectiveness of a 30-day physiotherapy programme in psychological wellness and health-related quality of life (HRQoL) of patients with advanced chronic diseases or cancer and in their caregivers' stress. METHODS: Quasiexperimental before-after study applying personalised kinesitherapy, exercise with curative effects, respiratory physiotherapy, therapeutic massages and ergotherapy. Psychological wellness, HRQoL and caregiver's strain outcomes were measured. RESULTS: 207 patients (60% men, with a mean age of 73.6±12 years) were included; 129 (62.3%) with advanced cancer, and the remaining 78 with advanced chronic diseases. Psychological wellness (Emotional Stress Detection Tool decreased from 12.4±3 to 11±3; p<0.0001), caregiver's strain (Caregiver Strain Index decreased from 8.5±3.2 to 7.9±3.5; p<0.0001) and HRQoL (WHO-BREF physical health domain increased from 8.3±2.6 to 9.4±2.9; p<0.0001) showed a significant improvement after the physiotherapy programme. Global satisfaction with the physiotherapy intervention was also high (Client Satisfaction Questionnaire-8 of 28.3±3.3 points). CONCLUSIONS: A personalised physiotherapy programme incorporated to integral palliative care improved psychological wellness, HRQoL and caregivers' strain of patients with advanced chronic diseases and cancer.

Corrigendum: The Influence of Unconscious Perceptual Processing on Decision-Making: A New Perspective From Cognitive Neuroscience Applied to Generation Z.

[This corrects the article DOI: 10.3389/fpsyg.2020.01728.].

Analysis of Emotion and Recall in COVID-19 Advertisements: A Neuroscientific Study.

In this research, neuroscience techniques are applied to the field of marketing in the analysis of advertisements that include the COVID-19 pandemic in their stories. A study of emotion and memory in these audiovisual productions is carried out as two fundamental factors for the knowledge of consumer habits and decision making. By means of facial recognition biosensor systems (AFFDEX) and various tests, six informative and narrative, emotional and rational advertisements are presented to the subjects of the experiment to detect which emotions predominate; how they affect variables such as neuroticism, psychoticism or extroversion, among others; or what is remembered about the different works, brands and advertisers. Outstanding results are obtained in both emotional and cognitive analysis. Thus, in the field of public health, it is found that messages referring to COVID-19 included in advertisements are remembered more than other narratives or even the brands, products or services themselves. Likewise, joy is the predominant emotion, and its significance in such varied advertising stories stands out. Finally, it is clear that neuroscience research applied to marketing requires new methods and integrated applications to obtain satisfactory results in the advertising field.

The Emotional Effectiveness of Advertisement.

Based on cognitive-emotional neuroscience, the effectiveness of advertisement is measured in terms of individuals' unconscious emotional responses. Using AFFDEX to record and analyze facial expressions, a combination of indicators that track both basic emotions and individual involvement is used to quantitatively determine if a spot causes high levels of ad liking in terms of attention, engagement, valence, and joy. We use as a test case a real campaign, in which a spot composed of 31 scenes (images, text, and the brand logo) is shown to subjects divided into five groups in terms of age and gender. The target group of mature women shows statistically more positive emotions and involvement than the rest of the groups, demonstrating the emotional effectiveness of the spot. Each other experimental groups show specific negative emotions as a function of their age and for certain blocks of scenes.

The Influence of Unconscious Perceptual Processing on Decision-Making: A New Perspective From Cognitive Neuroscience Applied to Generation Z.

Cognitive neuroscience and its applied developments have revolutionized marketing. With advances in neuroscientific techniques, marketing has needed to refocus toward understanding issues like the area of the brain that should be stimulated to transform the consumer's intention to purchase into a real decision, how information is processed when making a decision, and how personality traits affect the purchase decision. Neuroscience has opened the door to the consumer's brain. For many years, scientists have investigated the role of subliminal messages in marketing, with their findings generating a significant controversy. Many have shown that making sound decisions based on intuition rather than conscious reasoning is more common than previously thought. In fact, many studies have shown that sound intuitive decision-making depends on the association of the subliminal messages of a given situation with the limbic brain structures formed. Scientists have concluded that the brain does not consciously need to know contextual information to learn the value of this information and make the necessary linkages to make productive decisions. In this study, we consider whether unconscious perceptual processing influences decision-making and explore the influence of aspects of personality that are related to unconscious processing, such as the degree of neuroticism, extroversion, and gender of the individual, applied to the demographic cohort Generation Z, distinguishing between whether the stimuli are verbal or pictorial. The backward masking visual paradigm has been used to assess unconscious perceptual processing. To test these processes, a set of ANOVA models and logistic regressions were run where the dependent variable is whether the people perceived the stimuli or not and the independent variables were gender, the form of the stimuli (pictorial or verbal), and the personality traits extroversion, introversion, and neuroticism. The results suggest that verbal stimuli work better than pictorial stimuli, although a possible explanation is that the pictures require modification to be more effective. In the case of verbal stimuli, gender and level of neuroticism are found to be important variables that influence unconscious perceptual decision-making processes. Specifically, a female with a high level of neuroticism shows greater permeability in its unconscious perceptual processes.

Clinical performance of Determine HBsAg 2 rapid test for Hepatitis B detection.

Hepatitis B virus (HBV) infection is estimated to affect 292 million people worldwide, 90% of them are unaware of their HBV status. The Determine HBsAg 2 (Alere Medical Co, Ltd Chiba Japan [Now Abbott]) is a rapid test that meets European Union (EU) regulatory requirements for Hepatitis B surface antigen 2 (HBsAg) analytical sensitivity, detecting the 0.1 IU/mL World Health Organization (WHO) International HBsAg Standard. This prospective, multicentre study was conducted to establish its clinical performance. 351 evaluable subjects were enrolled, 145 HBsAg-positive. The fingerstick whole blood sensitivity and specificity were 97.2% and 98.5% (15' reading, reference assay cut-off 0.05 IU/mL), sensitivity increasing to 97.9% with the prespecified cut-off 0.13 IU/mL (EU regulations). The venous whole blood, serum and plasma sensitivity was 97.2%, 97.9%, and 98.6%, respectively (15' reading); reaching 99%, 99.5% and 100% specificity. A testing algorithm following up an initial positive fingerstick test result with plasma/serum test demonstrates 100% specificity. The Determine HBsAg 2 test gives 15-minute results with high sensitivity and specificity, making it an ideal tool for point-of-care testing, with the potential to enable large-scale population-wide screening to reach the WHO HBV diagnostic targets. The evaluated test improves the existing methods as most of the reviewed rapid tests do not meet the EU regulatory requirements of sensitivity.

Evaluation of dried blood spot samples for screening of hepatitis C and human immunodeficiency virus in a real-world setting.

Both hepatitis C virus (HCV) infection and human immunodeficiency virus (HIV) infection are underdiagnosed, particularly in low-income countries and in difficult-to-access populations. Our aim was to develop and evaluate a methodology for the detection of HCV and HIV infection based on capillary dry blood spot (DBS) samples taken under real-world conditions. We carried out a cross-sectional study of 139 individuals (31 healthy controls, 68 HCV-monoinfected patients, and 40 HCV/HIV-coinfected patients). ELISA was used for anti-HCV and anti-HIV antibody detection; and SYBR Green RT-PCR was used for HCV-RNA detection. The HIV serological analysis revealed 100% sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The HCV serological analysis revealed a sensitivity of 92.6%, specificity of 100%, PPV of 100%, and NPV of 79.5%. Finally, the HCV-RNA detection test revealed a detection limit of 5 copies/µl with an efficiency of 100% and sensitivity of 99.1%, specificity of 100%, PPV of 100%, and NPV of 96.9%. In conclusion, our methodology was able to detect both HCV infection and HIV infection from the same DBS sample with good diagnostic performance. Screening for HCV and HIV using DBS might be a key strategy in the implementation of national programs for the control of both infections.

A Novel Integrating Virtual Reality Approach for the Assessment of the Attachment Behavioral System.

Virtual reality (VR) technology represents a novel and powerful tool for behavioral research in psychological assessment. VR provides simulated experiences able to create the sensation of undergoing real situations. Users become active participants in the virtual environment seeing, hearing, feeling, and actuating as if they were in the real world. Currently, the most psychological VR applications concern the treatment of various mental disorders but not the assessment, that it is mainly based on paper and pencil tests. The observation of behaviors is costly, labor-intensive, and it is hard to create social situations in laboratory settings, even if the observation of actual behaviors could be particularly informative. In this framework, social stressful experiences can activate various behaviors of attachment for a significant person that can help to control and soothe them to promote individual's well-being. Social support seeking, physical proximity, and positive and negative behaviors represent the main attachment behaviors that people can carry out during experiences of distress. We proposed VR as a novel integrating approach to measure real attachment behaviors. The first studies on attachment behavioral system by VR showed the potentiality of this approach. To improve the assessment during the VR experience, we proposed virtual stealth assessment (VSA) as a new method. VSA could represent a valid and novel technique to measure various psychological attributes in real-time during the virtual experience. The possible use of this method in psychology could be to generate a more complete, exhaustive, and accurate individual's psychological evaluation.

Zona occludens-2 protects against podocyte dysfunction induced by ADR in mice.

Zona occludens-2 (ZO-2) is a protein present at the tight junction and nucleus of epithelial cells. ZO-2 represses the transcription of genes regulated by the Wnt/ß-catenin pathway. This pathway plays a critical role in podocyte injury and proteinuria. Here, we analyze whether the overexpression of ZO-2 in the glomerulus, by hydrodynamics transfection, prevents podocyte injury mediated by the Wnt/ß-catenin pathway in the mouse model of adriamycin (ADR) nephrosis. By immunofluorescence and immunogold electron microscopy, we show that ZO-2 is present in mice glomerulus, not at the slit diaphragms where nephrin concentrates, but in the cytoplasm and at processes of podocytes. Our results indicate that in the glomeruli of mice treated with ADR, ZO-2 overexpression increases the amount of phosphorylated ß-catenin, inhibits the expression of the transcription factor snail, prevents nephrin and podocalyxin loss, reduces podocyte effacement and massive fusions, restrains proteinuria, and supports urea and creatinine clearance. These results suggest that ZO-2 could be a new target for the regulation of hyperactive Wnt/ß-catenin signaling in proteinuric kidney diseases.

Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer.

BACKGROUND: High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women. METHODS: We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological check-up, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis. RESULTS: Median age was 42 years. The prevalence of HR-HPV infection was 33.2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3.8%. The most common genotypes were 16(23%), 53(20.3%), and 52(16.2%). The factor associated with HR-HPV infection was age <30 years (odds ratio[OR],2.5; 95%confidence interval[CI],1.1-5.6). The factors associated with the presence of HSIL or low-grade squamous intraepithelial lesions (LSIL) were CD4T-lymphocyte count <200 cells/mm(3) versus >500 cells/mm(3) (OR,8.4; 95%CI,3.7-19.2), HIV-1 viral load >10,000 copies/mL versus <400 copies/mL (OR,2.1; 95%CI,1.0-4.4), and use of oral contraceptives (OR,2.0; 95%CI,1.0-3.9). Sixty percent of HIV-1-infected women had had one Pap smear within the last 2 years. CONCLUSIONS: The high prevalence of HPV infection and cervical lesions in the HIV-1-infected population in Catalonia, as well as the low coverage and frequency of screening in this group, means that better preventive efforts are necessary and should include vaccination against HPV, better accessibility to screening programs, training of health care professionals, and specific health education for HIV-1-infected women.

Valoración del funcionamiento cognitivo en mujeres con cáncer de mama antes de iniciar el tratamiento oncológico / No disponible

Objetivo: El principal objetivo es describir el rendimiento cognitivo previo al tratamiento oncológico sistémico en mujeres con cáncer de mama dentro de un estudio longitudinal. Método: A 35 mujeres diagnosticadas de cáncer de mama no metastásico, con una edad media de 48,6 años, se les ha realizado una evaluación neurocognitiva, sobre diferentes dominios cognitivos, y psicológica (malestar emocional y percepción subjetiva de fallos cognitivos) antes de iniciar el tratamiento. Resultados: El 22,9% de la muestra precisa quimioterapia, el 28,6% hormonoterapia y el 48,6% un tratamiento combinado. Los resultados muestran que: (1) Entre un 62% y un 100% presenta un rendimiento normal en los distintos dominios cognitivos, excepto en memoria visual donde sólo un 43% cumple criterios de normalidad. (2) Aparece deterioro cognitivo leve en atención selectiva (23,5%) y memoria visual (14,4%), y deterioro cognitivo severo en atención y velocidad de procesamiento (28,6%) y memoria visual (22,9%). (3) Un porcentaje reducido de mujeres presenta niveles elevados de depresión y ansiedad (2,9% y 14,5%, respectivamente). (4) El 71% manifiesta baja percepción subjetiva de fallos cognitivos. (5) Los tests neurocognitivos y las variables psicológicas son independientes. (6) La percepción subjetiva del funcionamiento muescognitivo correlaciona con la ansiedad (r = – 0,409). Conclusión: Un número reducido de pacientes presenta deterioro cognitivo, antes de iniciar el tratamiento, de estos un porcentaje muestra deterioro severo. Es indispensable contar con una línea base de funcionamiento cognitivo para evaluar correctamente a estos pacientes y habría que revisar la metodología usada y la idoneidad de las pruebas neurocognitivas administradas (AU)

Objective: The aim of this study is to describe the cognitive achievement previous to oncological treatment in a group of breast cancer women included in a longitudinal study. Method: Thirty five non metastatic breast cancer women, with a mean age of 48.6 years old, were assessed in different neurocognitive domains and also in some psychological variables (emotional distress and subjective perception of cognitives failures) before to start the oncological treatment. Results: Twenty two percent of the group received chemotherapy alone, 28.6% hormonotherapy and 48.6% a mixed treatment (chemotherapy plus hormonotherapy). Results show that: (1) Bewteen a 62% and a 100% of the women present a normal achievement in the different cognitive domains, except for visual memory where only 43% gets into the normality. (2) There is a light cognitive impairment in selective attention (23.5%) and visual memory (14.4%), also there is a severe cognitive impairment in attention and processing speed (28.6%) and visual memory (22.9%). (3) A low percentage of women shows high levels of emotional distress, 2.9% for depression and 14.5% for anxiety. (4) The 71% reports a low subjective perception of cognitives failures. (5) Neurocogntive test and psychological variables do not show any correlation. (6) Subjective perception of cognitive failure correlates with anxiety (r = – 0.409). Conclusion: A reduced number of patients shows cognitive impairment before to start the oncological treatment, a small percentage of this group shows severe impairment. It is very important to have a baseline of cognitive functioning to correctly assess these patients. It is also necesary to review the methodology and the neurocognitive test used (AU)

Una mirada al género en la investigación. Análisis cualitativo / A look at gender in research. A qualitative analysis

ObjetivoConocer el punto de vista de un grupo de expertas nacionales, en género y salud, sobre los elementos clave que deben considerarse en una investigación con perspectiva de género y buscar qué tipo de resistencias operan cuando se pretende incluir esta perspectiva en la investigación.DiseñoEncuentro grupal de expertas. Se aplican 2 tipos de análisis: análisis del discurso y análisis de emergentes grupales.EmplazamientoZaragoza.ParticipantesGrupo integrado por 6 expertas. Experta, definido como persona con formación específica acreditada en el tema, y/o que hubiera presentado su trabajo de investigación sobre género y salud en los últimos años; o pertenezca a redes de investigación sobre género y salud.MétodoAnálisis cualitativo.ResultadosLa investigación con perspectiva de género debe responder a necesidades y problemas de salud de hombres y mujeres, teniendo especial interés aquellos temas que contribuyan a conocer la influencia del género en la salud de las personas. La metodología debe reflejar dicha perspectiva a lo largo de todo el proceso investigador y las variables deben tener potencial explicativo de género. Las principales resistencias que impiden incluir esta perspectiva son relativas a la institución científica, el feminismo y la falta de formación.ConclusionesNo puede considerarse que un proyecto tenga perspectiva de género si no incluye análisis de variables con potencial explicativo de género y no pretende contribuir a disminuir las desigualdades entre hombres y mujeres. Conocer las resistencias que dificultan este abordaje puede orientar futuras acciones formativas(AU)

ObjectiveTo find out the views of a group of national women experts on gender and health on the key elements to consider in research with a gender perspective, and what are the resistance barriers when trying to include this perspective in the research.DesignMeeting of a group of experts. Two types of analysis, discourse analysis, analysis of group outputs were used.LocationZaragoza.ParticipantsThe group consists of six experts. An expert was defined as person accredited with specific training in the subject, and/or has presented her research at seminars, workshops, conferences on gender and health in recent years, or belongs to one of the networks of research on gender and heath.MethodQualitative analysis.ResultsResearch with a gender perspective should meet the health needs and problems of both men and women, with those issues that contribute to determining the influence of gender on people's health being of special interest. The methodology should reflect this perspective throughout the research process and the variables should have gender explanatory potential. The main resistance barriers that prevent the inclusion of this perspective were related to the scientific institution, to feminism, and to a lack of training.ConclusionsA project cannot be considered to have a gender perspective if it does not include the analysis of variables with a gender explanatory potential and is not designed to help reduce inequalities between men and women. Knowing the resistance barriers that hinder this approach can guide future training(AU)

First report of sylvatic DENV-2-associated dengue hemorrhagic fever in West Africa.

Dengue virus (DENV) circulates in human and sylvatic cycles. Sylvatic strains are both ecologically and evolutionarily distinct from endemic viruses. Although sylvatic dengue cycles occur in West African countries and Malaysia, only a few cases of mild human disease caused by sylvatic strains and one single case of dengue hemorrhagic fever in Malaysia have been reported. Here we report a case of dengue hemorrhagic fever (DHF) with thrombocytopenia (13000/µl), a raised hematocrit (32% above baseline) and mucosal bleeding in a 27-year-old male returning to Spain in November 2009 after visiting his home country Guinea Bissau. Sylvatic DENV-2 West African lineage was isolated from blood and sera. This is the first case of DHF associated with sylvatic DENV-2 in Africa and the second case worldwide of DHF caused by a sylvatic strain.

[A look at gender in research. A qualitative analysis]. / Una mirada al género en la investigación. Análisis cualitativo.

OBJECTIVE: To find out the views of a group of national women experts on gender and health on the key elements to consider in research with a gender perspective, and what are the resistance barriers when trying to include this perspective in the research. DESIGN: Meeting of a group of experts. Two types of analysis, discourse analysis, analysis of group outputs were used. LOCATION: Zaragoza. PARTICIPANTS: The group consists of six experts. An expert was defined as person accredited with specific training in the subject, and/or has presented her research at seminars, workshops, conferences on gender and health in recent years, or belongs to one of the networks of research on gender and heath. METHOD: Qualitative analysis. RESULTS: Research with a gender perspective should meet the health needs and problems of both men and women, with those issues that contribute to determining the influence of gender on people's health being of special interest. The methodology should reflect this perspective throughout the research process and the variables should have gender explanatory potential. The main resistance barriers that prevent the inclusion of this perspective were related to the scientific institution, to feminism, and to a lack of training. CONCLUSIONS: A project cannot be considered to have a gender perspective if it does not include the analysis of variables with a gender explanatory potential and is not designed to help reduce inequalities between men and women. Knowing the resistance barriers that hinder this approach can guide future training.