Treatment options for mandibular canine transmigration - a case series based on dental literature.

The present case series, based on dental literature, aimed to identify factors that influence the final treatment decision for patients affected by mandibular canine transmigration using individual data from case reports in the literature. The protocol used for data synthesis was prepared following the Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines. An online search was conducted and included studies published up until September of 2019 (MEDLINE, Google Scholar, Scielo, and Conricyt). A chi squared test was used to evaluate associations between the treatment choice and gender, age, Mupparapu classification, and the presence of oral pathologies or dental anomalies (p < 0.05). A multinomial logistic regression was used to evaluate the individual case report data to determine the effect of the explanatory variables for treatment selection. Seventy-six papers fulfilled the inclusion criteria. Surgical removal (46.71%) and radiographic monitoring (38.16%) were the most common treatments reported. Age, Muppararu classification, and the presence of oral pathologies were significantly associated with the treatment option (p < 0.05). In conclusion, surgical removal and radiographic monitoring are the most frequently reported treatments for mandibular canine transmigration. Age, Mupparapu type, presence of oral pathologies, and qualitative aspects such as emotional reasons are relevant for the decision regarding treatment approach.

Periodontitis and Alzheimer´s disease.

BACKGROUND: Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the course of periodontitis (PE) are capable of inducing a systemic inflammatory response, exacerbating the production of proinflammatory mediators that have the potential to spread to the systemic circulation. MATERIAL AND METHODS: A literature review was made using the databases Scielo, PubMed, EBSCO and key words "Alzheimer disease", "Periodontitis", "Neurodegeneration", "Inflammation mediators", "Elderly". RESULTS: Several hypotheses point to similar pathophysiological pathways in the establishment of AD and PE, sharing cellular and molecular proinflammatory characteristics. In periodontitis, locally produced cytokines and pro-inflammatory products spread from the ulcerated periodontal pocket into the systemic circulation, or around the trigeminal nerve terminals, which allows the passage of bacteria or their products to the brain. This fact leads to the formation of plaques of amyloid peptide and intraneuronal neurofibrillar tangles (NFTs) that activate the glial cells producing a significant increase in proinflammatory cytokines in the affected regions that lead to a loss of neuronal synapses and neurodegeneration, contributing to the progression of AD. CONCLUSIONS: This review of the literature contributes to the understanding of the pathological pathways shared by both diseases such as oxidative damage and inflammation. There is not enough evidence to determine an association between this two pathologies, so it is considered necessary to conduct studies for determine if periodontitis is capable of inducing or exacerbating the neuroinflammation that will trigger AD.