Assuntos
Nádegas/patologia , Síndromes Compartimentais/etiologia , Overdose de Drogas/complicações , Rabdomiólise/etiologia , Adulto , Síndromes Compartimentais/patologia , Síndromes Compartimentais/fisiopatologia , Usuários de Drogas , Humanos , Hipocinesia/complicações , Hipocinesia/etiologia , Masculino , Rabdomiólise/patologia , Rabdomiólise/fisiopatologiaRESUMO
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Assuntos
Humanos , Masculino , Adulto , Síndromes Compartimentais/complicações , Rabdomiólise/complicações , Nádegas/fisiopatologia , Hepatite B Crônica/complicações , Hepatite C Crônica/complicaçõesRESUMO
Thirteen patients with nervous system brucellosis are described. The clinical signs were heterogeneous: meningoencephalitis in 5 cases, meningoradiculitis in another 5, meningomyelitis with cranial neuropathy in 1 and of a vascular nature in 2 others. Neurologic signs appeared during the active phase in 5 patients and later in 8. Diagnosis was based on clinical manifestations, serum and cerebrospinal fluid (CSF) serology, quantitative changes in CSF and favorable response to treatment. Therapy consisted of a combination of 2 or 3 of the following drugs: rifampin, doxycycline, streptomycin and trimethoprim sulfamethoxazole. In spite of favorable evolution, 5 patients suffered sequelae. We suggest that brucellosis be investigated when neurologic deficit ensues with no known etiology, especially in endemic countries.
Assuntos
Encéfalo/microbiologia , Brucelose/líquido cefalorraquidiano , Adolescente , Adulto , Idoso , Aminoglicosídeos , Antibacterianos/uso terapêutico , Antibióticos Antituberculose/uso terapêutico , Encéfalo/fisiopatologia , Brucella/isolamento & purificação , Brucelose/tratamento farmacológico , Brucelose/microbiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
Brainstem encephalitis is an unusual infection caused by a variety of agents, among them the herpes simplex (HS) virus. The difficulty of establishing a diagnosis by neurophysiological and radiological examination is greater in this type of encephalitis than in the usual form produced by HS. We describe a fatal case of brainstem encephalitis. Inflammatory and necrotic lesions in the pous and medulla confirmed the clinical diagnosis, while the etiology was determined by immuno-histo-chemical techniques and viral culture of the cerebral parenchyma. Early diagnosis of this form of encephalitis, based on new virological techniques, allows more effective antiviral treatment.
