The State- and Trait-Level Effects and Candidate Mechanisms of Four Mindfulness-Based Cognitive Therapy (MBCT) Practices: Two Exploratory Studies.

Objectives: The primary aim was to explore state- and trait-level effects and candidate mechanisms of four Mindfulness-Based Cognitive Therapy (MBCT) practices. Method: One hundred sixty adults self-selected from the general population were randomized to one of four mindfulness practices: body scan, mindful movement, breath and body, and befriending. Study 1 explored state-level self-compassion, mindfulness, decentering (mechanisms), and pleasantness of thoughts, emotions, and body sensations at multiple time points using two single mindfulness sessions. Study 2 explored trait-level self-compassion, mindfulness, decentering, interoceptive awareness, attentional control (mechanisms), anxiety, depression, and psychological quality of life pre-post 2 weeks of daily practice. Results: In study 1, state-level effects were demonstrated in all candidate mechanisms and outcomes within the whole sample across time points (d = 0.27 to 0.86), except for state decentering. After controlling for pre-scores and additional covariates, no between-group effects were found (p = 0.050 to 0.973). In study 2, trait-level effects were demonstrated in psychological quality of life and most candidate mechanisms within the whole sample (d = 0.26 to 0.64) but no between-group effects were found (p = 0.080 to 0.805). Within the whole sample, after controlling for pre-scores, changes in mindfulness, self-compassion, decentering, and interoceptive awareness (i.e. body listening) were associated with improvements in psychological quality of life (r = 0.23 to 0.40) and self-led mindfulness practice (r = 0.18 to 0.23). Conclusions: Future research should test the generated hypotheses using well-designed, adequately powered, and theory-driven studies that address universal and specific mechanisms in different populations and contexts. Pre-registration: This study is not pre-registered. Supplementary Information: The online version contains supplementary material available at 10.1007/s12671-023-02193-6.

Investigating the feasibility of MePlusMe, an online intervention to support mental health, well-being, and study skills in higher education students.

INTRODUCTION: While there are several web-based mental health interventions, few target higher education (HE) students. Importantly, more research is needed to establish their effectiveness. Here, we provide a pragmatic evaluation of an online intervention (MePlusMe) specifically designed to improve the mental health, well-being, and study skills of HE students. METHODS: In accordance with the published protocol for a feasibility study, we recruited a convenience sample of 137 HE students to participate in an eight-week intervention, with 26 participants retained at week 8. Validated measures of mood (depression and anxiety), well-being, and self-efficacy were collected at baseline, 2, 4, and 8 weeks, alongside two feedback forms assessing design and functionality (baseline) and engagement (week 4 and 8). RESULTS: We observed significant reductions in levels of anxiety and depression as well as increases in well-being, but no changes in self-efficacy. Participants rated the system design and functionality positively and qualitative findings indicated high levels of satisfaction with MePlusMe. DISCUSSION: Findings support both the acceptability and the effectiveness of MePlusMe. Nonetheless, modest retention rates limit the precision and generalisability of these findings. Further investigation should ascertain optimal duration of engagement, most acceptable means of outcome assessment, and further detail about obstacles to utilisation.

Human handedness: A meta-analysis.

Across time and place, right hand preference has been the norm, but what is the precise prevalence of left- and right-handedness? Frequency of left-handedness has shaped and underpinned different fields of research, from cognitive neuroscience to human evolution, but reliable distributional estimates are still lacking. While hundreds of empirical studies have assessed handedness, a large-scale, comprehensive review of the prevalence of handedness and the factors that moderate it, is currently missing. Here, we report 5 meta-analyses on hand preference for different manual tasks and show that left-handedness prevalence lies between 9.3% (using the most stringent criterion of left-handedness) to 18.1% (using the most lenient criterion of nonright-handedness), with the best overall estimate being 10.6% (10.4% when excluding studies assessing elite athletes' handedness). Handedness variability depends on (a) study characteristics, namely year of publication and ways to measure and classify handedness, and (b) participant characteristics, namely sex and ancestry. Our analysis identifies the role of moderators that require taking into account in future studies on handedness and hemispheric asymmetries. We argue that the same evolutionary mechanisms should apply across geographical regions to maintain the roughly 1:10 ratio, while cultural factors, such as pressure against left-hand use, moderate the magnitude of the prevalence of left-handedness. Although handedness appears as a straightforward trait, there is no universal agreement on how to assess it. Therefore, we urge researchers to fully report study and participant characteristics as well as the detailed procedure by which handedness was assessed and make raw data publicly available. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

A randomized clinical trial of mindfulness-based cognitive therapy for women with irritable bowel syndrome-Effects and mechanisms.

OBJECTIVE: Irritable bowel syndrome (IBS) is a chronic disorder of brain-gut interaction. Previous studies suggest that mindfulness could be therapeutic for IBS patients, however no study has evaluated the effects of mindfulness-based cognitive therapy adapted for patients with IBS (MBCT-IBS). A 6-week MBCT-IBS course was designed to reduce symptoms and increase quality of life. This study aimed to evaluate the effects of MBCT-IBS and to investigate its therapeutic mechanisms in a randomized controlled trial. METHOD: Sixty-seven female patients with IBS were randomized to MBCT-IBS (MG; n = 36) or a waitlist (WL; n = 31) control condition. Patients completed standardized self-report measures of IBS symptom severity, IBS quality of life, maladaptive illness cognitions (catastrophizing, visceral anxiety sensitivity) and mindfulness at baseline, after 2 treatment sessions, at posttreatment, and at 6-week follow-up. Self-referential processing of illness and health was measured with an implicit association test (IAT). RESULTS: The MG reported significantly greater reductions in IBS symptoms (p = .003) and improvements in quality of life (p < .001) at follow-up compared with the WL. Changes in visceral anxiety sensitivity and pain catastrophizing at posttreatment and reductions in the IAT-score after 2 sessions combined with increases in nonjudgmental awareness at posttreatment mediated reductions in IBS symptoms. CONCLUSIONS: MBCT-IBS has the potential to reduce IBS symptoms and increase quality of life. MBCT-IBS may exert its effect on IBS symptoms via reducing maladaptive illness cognitions and activating changes in self-processing (reducing biases in self-referent processing of illness and health and increasing nonjudgmental awareness). (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Evidence for mood-dependent attentional processing in asthma: attentional bias towards health-threat in depressive mood and attentional avoidance in neutral mood.

Attentional biases have been observed in populations with psychological disorders, but have been under-investigated in populations with physical illnesses. This study investigated potential attentional biases in asthma as a function of mood. Asthma (N = 45), and healthy (N = 39) participants were randomly allocated to a depressed or a neutral mood state induction. They completed a visual probe task that measured participants' reaction times to health-threat and neutral pictures and words. Compared to the healthy controls, the asthma group showed attentional bias towards health-threat pictures in depressed mood, and avoidance of health-threat pictures in neutral mood. Attentional biases were found in a group with a physical illness as a function of induced mood. It is suggested that attentional processes in people with physical illness may be important in relation to symptom perception and illness management.

Altered attentional control linked to catastrophizing in patients with irritable bowel syndrome.

OBJECTIVES: Our study aimed to investigate differences in attentional control between patients with irritable bowel syndrome (IBS) and healthy participants and to examine the link between attentional control and IBS catastrophizing. Previous research has shown that patients with chronic functional illnesses have lower levels of attentional control. However, no previous study has found altered attentional control in patients with IBS or directly investigated the link between attentional control and catastrophizing. We also aimed to establish whether anxiety is associated with attentional functions in patients with IBS. DESIGN AND METHODS: In this cross-sectional study, we compared 41 IBS patients with 39 healthy-matched control participants on attentional functions using an attention network task. IBS catastrophizing (Gastrointestinal Cognitions), IBS symptom severity (GSRS-IBS), Depression, Anxiety, and Stress (DASS-21), and Visceral Anxiety Sensitivity were assessed using self-report measures. RESULTS: Patients with IBS had lower attentional control compared to healthy participants, t (78) = -2.75, p = .007, d = .62. Groups did not differ in alerting or orienting attention. IBS patients with lower attentional control scored higher on IBS catastrophizing than those with higher attention control, t (38.59) = 2.19, p = .032, d = .66. Anxiety was related to orienting attention in the IBS group (ρ = .38, p = .015). CONCLUSIONS: Patients with IBS displayed reduced attentional control. Crucially, those patients with lower attentional control also had more catastrophizing thoughts than patients with better attentional control. These findings suggest that improving attentional control could be a valid target for psychological interventions for IBS. Statement of contribution What is already known on this subject? It has been hypothesised that psychological processes play a role in the maintenance of irritable bowel syndrome (IBS), and altered levels of attentional control have been found in patients with other functional illnesses but not yet in patients with IBS. Pain catastrophizing, a maladaptive thinking pattern, has been linked with IBS symptom severity, and previous research has shown an association between attentional control and intrusive thoughts. Whether there is an association between catastrophizing thoughts and attentional control in patients with IBS is unknown. What does this study add? Patients with irritable bowel syndrome show reduced levels of attentional control. IBS patients with lower levels of attentional control have more catastrophizing thoughts. Therapies emphasizing attentional control training may help reduce catastrophizing.

Cerebral laterality for language is related to adult salivary testosterone levels but not digit ratio (2D:4D) in men: A functional transcranial Doppler ultrasound study.

The adequacy of three competing theories of hormonal effects on cerebral laterality are compared using functional transcranial Doppler sonography (fTCD). Thirty-three adult males participated in the study (21 left-handers). Cerebral lateralization was measured by fTCD using an extensively validated word generation task. Adult salivary testosterone (T) and cortisol (C) concentrations were measured by luminescence immunoassay and prenatal T exposure was indirectly estimated by the somatic marker of 2nd to 4th digit length ratio (2D:4D). A significant quadratic relationship between degree of cerebral laterality for language and adult T concentrations was observed, with enhanced T levels for strong left hemisphere dominance and strong right hemisphere dominance. No systematic effects on laterality were found for cortisol or 2D:4D. Findings suggest that higher levels of T are associated with a relatively attenuated degree of interhemispheric sharing of linguistic information, providing support for the callosal and the sexual differentiation hypotheses rather than the Geschwind, Behan and Galaburda (GBG) hypothesis.

Salivary testosterone levels are unrelated to handedness or cerebral lateralization for language.

Behavioural and cerebral lateralization are thought to be controlled, at least in part, by prenatal testosterone (T) levels, explaining why sex differences are found in both laterality traits. The present study investigated hormonal effects on laterality using adult salivary T levels, to explore the adequacy of competing theories: the Geschwind, Behan and Galaburda, the callosal, and the sexual differentiation hypotheses. Sixty participants (15 right-handers and 15 left-handers of each sex) participated. Behavioural lateralization was studied by means of hand preference tests (i.e., the Edinburgh Handedness Inventory and the Quantification of Hand Preference test) and a hand skill test (i.e., the Peg-Moving test) whereas cerebral lateralization for language was studied using the Consonant-Vowel Dichotic Listening test and the Visual Half-Field Lexical Decision test. Salivary T and cortisol (C) concentrations were measured by luminescence immunoassay. Canonical correlations did not reveal significant relationships between T levels and measures of hand preference, hand skill, or language laterality. Thus, our findings add to the growing literature showing no relationship between T concentrations with behavioural or cerebral lateralization. It is claimed that prenatal T is not a major determinant of individual variability in either behavioural or cerebral lateralization.

Measuring hand preference: a comparison among different response formats using a selected sample.

Hand preference (HP) is a major behavioural variable for inferring individual differences in neurological organisation. Yet, despite the extensive use of HP measures for both research and clinical purposes, there is little research on the properties of the structural features of HP questionnaires, the most common method of HP measurement. We study here the effects of different response formats of HP questionnaires on participants' responses. A total of 200 volunteers (100 left-handers, 50 male; 100 right-handers, 50 male) completed two versions of a composite HP questionnaire containing the items of the Annett, Edinburgh, Healy, and Waterloo instruments, one with a binary response format and the other with a 5-point graded response format. The tendency towards extreme responses and the mapping between a graded either response and a binary left/right response were investigated. It was found that both patterns were significantly influenced by participant handedness, but not by sex. Finally, in terms of the overall ordering of participants by HP measures, considerable consistency was found across questionnaire content and response format.

Individualism and the field viewpoint: cultural influences on memory perspective.

Two perspectives from which memories can be retrieved have been distinguished: field resembles the view from the first-person vantage point of original experience, whereas observer resembles the view from the third-person vantage point of a spectator. There is evidence that the incidences of the two types of perspective differ between at least two different cultural groups. It is hypothesised here that this is a special case of a more general relation between memory perspective and cultural individualism, such that field and observer perspectives are more prevalent among people from, respectively, relatively individualist and relatively collectivist societies. Memory perspectives adopted by participants from a range of different countries were recorded, and were found to vary in the predicted manner. Regression analysis showed that the potential effects of three other cultural variables - uncertainty avoidance, masculinity and, to a lesser extent, power distance - were eclipsed by the influence of individualism, and the implications are discussed.

Attention to pain words in irritable bowel syndrome: increased orienting and speeded engagement.

OBJECTIVES: Biopsychosocial models suggest altered attention to pain plays a role in the aetiology of irritable bowel syndrome (IBS). We investigated whether attention to pain words differed in IBS participants relative to healthy controls, and whether attentional indices predicted self-reported health and illness behaviour. DESIGN: A between-subjects design was used to enable investigation of differences between an IBS participant group and a healthy participant group. METHODS: Twenty IBS participants and 33 healthy controls completed a modified version of a task commonly used to investigate attentional processes, the exogenous cueing task. Attentional bias, engagement, and disengagement indices were calculated from reaction time data to assess attention to pain and social threat words. Questionnaires were used to investigate self-reported health and illness behaviour. RESULTS: Relative to controls, IBS participants were more biased towards pain than neutral words, showing faster engagement with pain words than controls. Measures of attention to pain words were associated with increased reporting somatic symptoms and sick leave taking. CONCLUSIONS: These results support atypical attention to pain in IBS and suggest these attentional biases are associated with increased pain report and illness behaviour. A vicious circle maintenance model of IBS, in which attentional biases exacerbate symptom perception and illness behaviour, increasing focus on pain, is a potential explanation of these findings.

Sex and location as determinants of handedness: reply to Vuoksimaa and Kaprio (2010).

In response to the comment by Vuoksimaa and Kaprio (2010) on our previous article on sex differences in left-handedness (Papadatou-Pastou, Martin, Munafò, and Jones, 2008), we carried out an additional meta-analysis to explore whether the widely observed tendency for rates of left-handedness to be greater among male than female individuals is also found in Scandinavian (Nordic) studies. The overall male-to-female ratio for left- to right-handedness odds provides evidence in favor of this hypothesis. However, the results were subject to a significant moderating effect related to nation of origin. We discuss the potential impact on observed measures of additive rather than multiplicative processes that may underlie sex differences in handedness and also the date-of-study effect on handedness rates.

Mood volatility with rumination but neither attentional nor interpretation biases in chronic fatigue syndrome.

OBJECTIVES: This study tested whether (1) chronic fatigue syndrome (CFS) individuals have a bias in the initial orientation of attention to illness-related information, which is enhanced by rumination. (2) CFS individuals have an illness interpretation bias (IB) in their early automatic processing of ambiguous information. (3) CFS individuals experience a greater degree of mood fluctuation following rumination and distraction inductions. DESIGN: Thirty-three CFS participants who had received a medical practitioner's diagnosis of CFS were compared to 33 healthy matched controls on an exogenous cueing task and a lexical decision task. METHOD: All participants underwent either a rumination or distraction induction. They then completed an exogenous cueing task to assess bias to illness and social threat compared with neutral stimuli, as well as a lexical decision task to assess their interpretation of ambiguous words having illness, social threat, or neutral interpretations. RESULTS: Reaction time data revealed that CFS individuals did not have an attentional bias (AB) in the initial orientation of attention to illness-related material. Nor was there an IB towards illness in CFS individual's automatic response to ambiguous information. However, as hypothesized, CFS individuals showed a greater degree of mood fluctuation following the rumination/distraction induction. CONCLUSION: Rumination and distraction lead to greater mood volatility in CFS individuals than in controls, but not to attentional nor interpretation biases in the early automatic stages of information processing in CFS individuals.

Language dominance, handedness and sex: recessive X-linkage theory and test.

The possibility is investigated that cerebral dominance for language and handedness share a common X-linkage and that the relation between the two is therefore a function of sex. In particular, an X-linked recessive account is shown to predict an overall configuration of language dominance, handedness and sex within which there is a sex effect in the pattern of language dominance among right-handed but not left-handed people. The recent accurate determination of cerebral dominance among relatively large samples of the general population by means of functional transcranial Doppler ultrasonography makes it possible to test this new theory rigorously, and its parameter-free pattern of predictions is found to be supported.

Cognitive processing in putative functional gastrointestinal disorder: rumination yields orientation to social threat not pain.

Two possible roles of selective attention in the development and maintenance of functional gastrointestinal disorders (FGID) such as irritable bowel syndrome (IBS) were examined. First, hypervigilance to pain within FGID may exacerbate pain perception and pain-related distress. Second, hypervigilance to socially threatening stimuli could account for the disrupted social functioning reported by patients. Furthermore, stress-related variations in reported symptom severity and functioning impairments may reflect changes in cognitive bias with psychological state. Patterns of selective attention were probed within a sample of putative FGID participants (pFGID). The effect of rumination induction on performance on a modified exogenous cueing task was examined. Thirty-three women with pFGID and 27 matched controls responded to dot probes following pain, social threat and neutral word cues, both before and after rumination (passive self-focused thought), or distraction induction. Reaction times revealed that after rumination but not neutral distraction, pFGID participants showed enhanced attention to social threat words, but not to pain or neutral words. Between-group differences in mood, anxiety or depression could not account for these effects. These results implicate selective attention in social but not pain-related idiosyncrasies in FGID including IBS.

Affect and alexithymia determine choice among valued objects.

Why do people choose to surround themselves with possessions? An explanation has been offered by D. A. Norman (2004) in terms of the stimulation of 3 levels of psychological processing that map onto an object's appearance, its usability, and its ability to evoke reflective processing, including emotion. Two experiments were carried out to investigate participants' choices among valued objects, and found that affective factors (including links to current and past, euphoric and dysphoric emotion) played a dominant role in predictive modeling. The role was, however, significantly modulated by alexithymia. The extent to which object choice could be predicted was lower for those with higher levels of alexithymia than for those with lower levels. Nevertheless, a prominent linkage to current dysphoria was observed to emerge for higher levels of alexithymia, whose implications are considered.

Spatial recall improved by retrieval enactment.

Evidence from studies of intentional learning suggests that the accuracy of recall is not assisted by appropriate enactment at retrieval, as opposed to encoding. In the present study, long-term recall of spatial arrays following incidental learning (text messaging or calculator use) was tested under three different motor conditions at retrieval. For both letter and number arrays, the accuracy of recall was found to be improved by relevant enactment at the time of retrieval, relative to retrieval with no movement. In contrast, irrelevant movement was found to produce an impairment in accuracy. The overall accuracy of recalling a letter array was found to be a power-law function of the frequency of exposure to the array. The findings are discussed in terms of the hypothesis that appropriate movement during memory retrieval recruits egocentric representations that supplement allocentric representations subserving longer term spatial recall.

Sex differences in left-handedness: a meta-analysis of 144 studies.

Human handedness, a marker for language lateralization in the brain, continues to attract great research interest. A widely reported but not universal finding is a greater male tendency toward left-handedness. Here the authors present a meta-analysis of k = 144 studies, totaling N = 1,787,629 participants, the results of which demonstrate that the sex difference is both significant and robust. The overall best estimate for the male to female odds ratio was 1.23 (95% confidence interval = 1.19, 1.27). The widespread observation of this sex difference is consistent with it being related to innate characteristics of sexual differentiation, and its observed magnitude places an important constraint on current theories of handedness. In addition, the size of the sex difference was significantly moderated by the way in which handedness was assessed (by writing hand or by other means), the location of testing, and the year of publication of the study, implicating additional influences on its development.

Seasonal anisotropy in handedness.

The preference for using either the left or the right hand has been linked to important human characteristics such as language lateralisation within the cerebral hemispheres, and evidence has been reported that the proportions of different types of handedness may be influenced by factors such as levels of maternal hormones and anxiety. Under such influences, it is possible in principle that distributions of handedness provide evidence of seasonal anisotropy, that is, variation in the direction of handedness for births in different parts of the year. The results of a number of studies are compared here, and shown to provide evidence of a significant tendency for the incidence of left-handed people to be higher among those born in the spring and ensuing months (March-July in the northern hemisphere) than among those born in the remainder of the year, at least among the male population.

Asymptotic learning of alphanumeric coding in autobiographical memory.

Studies of autobiographical memory have shown that observed levels of incidental learning are often relatively low. Do low levels of retention result simply from a low learning rate, or is learning also asymptotic? To address this question, it is necessary to trace performance over a large number of learning opportunities, and this was carried out in the context of the recent development of widespread texting behaviour. It was found that memory for the alphanumeric layout of a phone improved as a function of sending approximately the first 500 texts, but then the improvement stopped. The incidence of memory error was incompatible with a simple power-law relation but was modelled closely by an asymptotic relation. It is suggested that this pattern reflects a movement towards automaticity in the primary task which progressively closes down the possibility that incidental learning can occur.