[Improvement of the solubility behavior of problem drugs. 9. In vitro absorption studies using melting solidification products of iomeglamic acid]. / Beiträge zur Verbesserung des Auflösungsverhaltens von Problemarzneistoffen. 9. Mitteilung: In-vitro-Resorptionsuntersuchungen mit lomeglamsäure-Schmelzerstarrungsprodukten.

By means of the absorption apparatus according to Fürst and Neubert the solid dispersions of the iomeglamic acid were studied with regard to their in vitro absorption properties. All products showed better half lives of transport in relation to the pure compound. This was in correlation to the solubility parameters.

[Improvement of the solubility of problem drugs. 1. Production of iomeglamic acid fused and solidified products]. / Beiträge zur Verbesserung des Auflösungsverhaltens von Problemarzneistoffen. 1. Mitteilung: Herstellung eines lomeglamsäure-Schmelzerstarrungsproduktes.

The insoluble X-ray diagnostic iomeglamic acid could be converted to a more soluble modification by melting and solidifying it in liquid nitrogen. The amorphous state is proved by X-ray diffraction and differential thermal analysis. During storage, recristallisation of the product appears. By means of the proved amorphous state, it seems possible to determine the amount of the amorphous state, which makes the drug more soluble from solid dispersions.