1.
Bioorg Med Chem Lett
; 16(10): 2608-12, 2006 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16516471
RESUMO
Potent inhibitors of the human PDE IV enzyme are described. Substituted 8-arylquinoline analogs bearing nitrogen-linked side chain were identified as potent inhibitors based on the SAR described herein. The pharmacokinetic profile of the best analog and the in vivo efficacy in an ovalbumin-induced bronchoconstriction assay in conscious guinea pigs are reported.