RESUMO
OBJECTIVE: To investigate plasma disposition, concentration in the hair, and anthelmintic efficacy of eprinomectin after topical administration in donkeys. ANIMALS: 12 donkeys naturally infected with strongyle nematodes. PROCEDURES: The pour-on formulation of eprinomectin approved for use in cattle was administered topically to donkeys at a dosage of 0.5 mg/kg. Heparinized blood samples and hair samples were collected at various times between 1 hour and 40 days after administration. Samples were analyzed via high-performance liquid chromatography with fluorescence detection. Fecal strongyle egg counts were performed by use of a modified McMaster technique before and at weekly intervals for 8 weeks after treatment. RESULTS: Plasma concentration and systemic availability of eprinomectin were relatively higher in donkeys, compared with values reported for other animal species. Concerning the anthelmintic efficacy against strongyle nematodes, eprinomectin was completely effective (100%) on days 7 and 14 and highly effective (> 99%) until the end of the study at 56 days after treatment. No abnormal clinical signs or adverse reactions were observed for any donkeys after treatment. CONCLUSIONS AND CLINICAL RELEVANCE: Eprinomectin had excellent safety. The relatively high plasma concentration after topical administration could result in use of eprinomectin for the control and treatment of parasitic diseases in donkeys.
Assuntos
Anti-Helmínticos/farmacocinética , Equidae/parasitologia , Cabelo/química , Ivermectina/análogos & derivados , Infecções por Strongylida/veterinária , Strongyloidea/efeitos dos fármacos , Administração Cutânea , Animais , Anti-Helmínticos/administração & dosagem , Anti-Helmínticos/análise , Anti-Helmínticos/sangue , Equidae/sangue , Equidae/metabolismo , Fezes/parasitologia , Feminino , Ivermectina/administração & dosagem , Ivermectina/análise , Ivermectina/sangue , Ivermectina/farmacocinética , Masculino , Contagem de Ovos de Parasitas/veterinária , Infecções por Strongylida/tratamento farmacológico , Infecções por Strongylida/parasitologia , Strongyloidea/isolamento & purificação , Resultado do TratamentoRESUMO
A trial to assess the efficacy of eprinomectin (EPM) against the lungworm Dictyocaulus arnfieldi was carried out on 15, naturally-infected donkeys. Ten animals were treated with a 'pour-on' EPM preparation (at a dose of 0.5 mg/kg bodyweight), and five animals acted as controls. Faecal larval counts were carried out two days before treatment, on day of treatment and 7, 14, 21 and 28 days post-treatment with the anthelmintic. EPM was 100% effective in eliminating faecal larvae from day 7, until the end of study at day 28. No adverse drug-reactions or side-effects were observed in any of the treated donkeys.