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1.
J Orthop Sci ; 2022 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-36446671

RESUMO

BACKGROUND: This study aimed to evaluate the effects of orthogeriatric co-management of hip fractures at a regional core hospital. METHODS: This study included patients with proximal hip fracture. Patients were divided into two groups, conventional multidisciplinary group I including patients attending the hospital between April 2015 and March 2016 and orthogeriatric group II including patients attending the hospital between April 2016 and March 2017, which were compared etrospectively. In the control group, the conventional multidisciplinary team treated patients as whole-body controls. In the intervention group, the newly recruited geriatricians performed physical examinations, laboratory tests, radioactive imaging, and physiological tests. Furthermore, they consulted ward pharmacists, rigorously conducted positive polypharmacy interventions , and evaluated the type and number of mediated drugs on admission. RESULTS: The number of medicated drugs significantly decreased from 6.03 ± 4.3 on admission to 5.50 ± 3.59 on discharge in group II, whereas group I did not show a significant decrease. Despite the more number of hospitalized patients in group II (166 patients) than in group I (126 patients), the recovery rate from postoperative urinary retention increased significantly from 57.8% (19/30) in group I to 84.3% (32/59) in group II (p = 0.049), while the incidence of aspiration pneumonia decreased from 7.1% (9/126) in group I to 2.49% (4/166) in group II (p = 0.08). The patients received six or more prescribed drugs on admission, and the number remained constant. However, the number of medicated drugs on discharge showed a marginally significant decrease from 6.03 ± 4.3 in group I to 5.50 ± 3.59 in group II (p < 0.05). CONCLUSIONS: Compared to the conventional multidisciplinary group, the orthogeriatric team contributed to reducing the number of multi-effect drugs and perioperative complications without negatively affecting mortality despite the increased number of patients. The in-hospital mortality rate did not change between the groups. The orthogeriatric program succeeded in preventing and treating perioperative complications.

2.
Acta Med Okayama ; 76(4): 409-414, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36123155

RESUMO

We assessed risk factors for postoperative urinary retention (UR) in elderly males with femoral bone fractures: 169 Japanese males (mean age 81.95 ± 1.19 years) who had undergone hip surgery at a municipal hospital (Toyama, Japan). A multiple logistic regression analysis was used to test possible risk factors for UR: age, body mass index, serum albumin, cognitive impairment, activities of daily living (ADL), and history of diabetes mellitus (DM). UR occurred in 24 (14.2%) of the 169 patients. A multivariate logistic regression analysis with age adjustment showed that ADL (odds ratio [OR] 3.88; 95% confidence interval [CI]: 1.2-12.5, p=0.023) was significantly associated with the development of UR, and a history of DM showed marginal significance for UR occurrence (OR 0.36, 95%CI: 0.11-10, p=0.064). These results suggests that ADL is a risk factor for UR development in elderly males who have undergone surgery for femoral neck or trochanter fractures.


Assuntos
Diabetes Mellitus , Fraturas do Quadril , Retenção Urinária , Atividades Cotidianas , Idoso , Idoso de 80 Anos ou mais , Colo do Fêmur , Fraturas do Quadril/cirurgia , Humanos , Japão/epidemiologia , Masculino , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Albumina Sérica , Retenção Urinária/complicações , Retenção Urinária/etiologia
3.
J Clin Med Res ; 12(10): 668-673, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33029274

RESUMO

BACKGROUND: The main purpose of this study is to exhaustively explore risk factors, including age, gender, and several clinical indices, for mortality in elderly patients with femoral neck fracture and to evaluate some of them using survival analyses. METHODS: This was a retrospective study tracking 1 year for vital prognosis. Data were collected at post-operation from medical records of the cases. Survival analysis was conducted to investigate the risk factors for death, including albumin, urinary retention, activity of daily living (ADL), and cognitive disorder. RESULTS: We recruited 318 patients with a history of hip surgery carried out at Toyama Municipal Hospital, in which 39 patients died for 1 year after discharge. The results showed a significant decrease in survival rate in low albumin, positive urinary retention, and low ADL (P < 0.01, by log-rank test). The hazard ratios (95% confidence interval) of albumin, urinary retention, ADL, and cognitive disorder were 0.36 (0.19 - 0.69), 0.4 (0.2 - 0.8), 0.29 (0.15 - 0.58) and 0.65 (0.32 - 1.29), respectively. CONCLUSIONS: This study demonstrated that albumin, urinary retention and ADL were the important risk factors for mortality, and suggested that the postoperative management of albumin, urinary retention and ADL is important, especially in elderly female patients receiving surgery of femoral neck and trochanteric fractures.

4.
Medicine (Baltimore) ; 99(7): e19108, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32049822

RESUMO

Aspiration pneumonia (AP) has been recognized as one of the most common postoperative complications after hip surgery in elderly. The objective of the present study was to evaluate risk for postoperative complications of AP in elderly patients with femoral neck fractures.We recruited 426 patients (age 84.9 ±â€Š7.4 years) with a history of hip surgery carried out at Toyama Municipal Hospital. AP occurred in 18 out of 426 cases (4.23%). Statistical test has found significant differences in age, gender, serum albumin level, and cognitive impairment, between AP and non-AP groups. Subsequently multiple logistic regression analysis was conducted to investigate the risk factors for AP, including age, gender, serum albumin, cognitive impairment, and activities of daily living (ADL). Adjusted odds ratio showed significant differences in age, gender, and serum albumin, whereas no significant differences were found in cognitive impairment and ADL.This study suggested that serum albumin seemed to be a risk factor for AP but were necessary to assess under adjustment of confounding factors, including age and gender. Monitoring serum albumin level seemed to be important for the postoperative management of AP, especially in elderly patients receiving surgery of femoral neck and trochanteric fractures.


Assuntos
Fraturas do Colo Femoral/complicações , Pneumonia Aspirativa/etiologia , Complicações Pós-Operatórias/etiologia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Fraturas do Colo Femoral/cirurgia , Humanos , Masculino , Pneumonia Aspirativa/epidemiologia , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Fatores de Risco , Albumina Sérica , Fatores Sexuais
5.
J Arthroplasty ; 35(5): 1417-1423, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-31948813

RESUMO

BACKGROUND: Low polyethylene wear rate and low incidence of osteolysis have been reported after total hip arthroplasty (THA) using first-generation remelted highly cross-linked polyethylene (HXLPE). However, osteolysis has not been evaluated in long-term studies of these patients (15 years or more). The present study assessed computed tomography (CT) images to determine the incidence of osteolysis associated with HXLPE in THA during at least 15 years of follow-up. METHODS: We evaluated 105 primary THAs in 84 patients (77 women and 7 men). Mean follow-up was 15.9 years (range, 15-18 years). All THAs used a Longevity HXLPE liner and a 26-mm zirconia femoral head. Areas of osteolysis were identified from CT images using 3D and multiplanar reconstruction views. RESULTS: CT 3D multiplanar reconstruction images at 15-year follow-up showed no obvious osteolysis in the acetabulum or femur of any patient. No patients developed cup loosening or liner breakage. CONCLUSION: Our study indicates that first-generation remelted HXLPE liners do not increase the risk of osteolysis during 15-year follow-up and suggests that the wear particles from first-generation remelted HXLPE are less biologically active than those generated by conventional polyethylene devices.


Assuntos
Artroplastia de Quadril , Prótese de Quadril , Osteólise , Artroplastia de Quadril/efeitos adversos , Feminino , Seguimentos , Prótese de Quadril/efeitos adversos , Humanos , Masculino , Osteólise/diagnóstico por imagem , Osteólise/epidemiologia , Osteólise/etiologia , Polietileno , Desenho de Prótese , Falha de Prótese , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
6.
Medicine (Baltimore) ; 98(24): e16023, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31192952

RESUMO

Urinary retention (UR) has been recognized as one of the most common postoperative complications after hip surgery in elderly. The objective of the present study was to evaluate risk for postoperative complications of UR in elderly female patients with femoral neck fractures.We recruited 221 female patients (age 85.3 ±â€Š7.0 years) with a history of hip surgery carried out at Toyama Municipal Hospital. UR occurred in 34 out of 221 cases (15.4%). Multiple logistic regression analysis was conducted to investigate the risk factors for UR, including age, body mass index (BMI), serum albumin, cognitive impairment, and activities of daily living (ADL).The results showed significant association of UR with cognitive impairment (P = .005, odds ratio [OR] 4.11, 95% confidence interval [CI] 1.53-11.03), and ADL (P = .029, OR 2.61, 95% CI 1.11-6.18), under adjustment with age and BMI.This study demonstrated that cognitive function and ADL were the important risk factors for UR, suggested that the postoperative management of UR is important with taking account of neurofunctional assistance and nursing care in daily living, especially in elderly female patients receiving surgery of femoral neck and trochanteric fractures.


Assuntos
Fraturas do Colo Femoral/cirurgia , Fraturas do Quadril/cirurgia , Complicações Pós-Operatórias , Retenção Urinária/etiologia , Atividades Cotidianas , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/metabolismo , Cognição , Disfunção Cognitiva/epidemiologia , Feminino , Fraturas do Colo Femoral/epidemiologia , Fraturas do Colo Femoral/psicologia , Fraturas do Quadril/epidemiologia , Fraturas do Quadril/psicologia , Humanos , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Fatores de Risco , Retenção Urinária/epidemiologia
7.
Int J Rheum Dis ; 20(10): 1372-1382, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27943574

RESUMO

AIM: As society ages, there is a vast number of elderly people with locomotive syndrome. In this study, the factors associated with functional limitations in daily living activities evaluated by female hip osteoarthritis (OA) patients were investigated. METHODS: This study was a cross-sectional study. The subjects were 353 female patients who were newly diagnosed with hip OA at an orthopedic clinic with no history of hip joint surgery. Outcome indices were functional limitations in two daily living activities obtained from a questionnaire completed by the patients: (i) standing up (standing from a crouched position) and (ii) stair-climbing (climbing and/or descending stairs). The odds ratios (ORs) and 95% confidence intervals (CIs) were computed for explanatory variables using the proportional odds model in logistic regression to evaluate their associations with functional limitations. RESULTS: Functional limitations in standing up were associated with heavy weight (third tertile vs. first tertile: 1.91, 1.11-3.27), participation in sports at school (0.62, 0.40-0.98), parity (vs. nullipara: 1.96, 1.08-3.56), old age and OA stage. Associations with functional limitations in stair-climbing were seen with short height (< 151.0 cm vs. ≥ 156.0 cm: 2.05, 1.02-4.12), bilateral involvement (vs. unilateral: 1.71, 1.01-2.88), old age and OA stage. CONCLUSION: Old age, OA stage, heavy weight, parity, shorter height and bilateral OA were associated with functional limitations in standing up and/or stair-climbing, whereas participation in sports such as club activities in school maintained standing up.


Assuntos
Atividades Cotidianas , Articulação do Quadril/fisiopatologia , Osteoartrite do Quadril/fisiopatologia , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Povo Asiático , Fenômenos Biomecânicos , Estatura , Estudos Transversais , Avaliação da Deficiência , Feminino , Humanos , Japão/epidemiologia , Modelos Logísticos , Pessoa de Meia-Idade , Análise Multivariada , Razão de Chances , Osteoartrite do Quadril/diagnóstico , Osteoartrite do Quadril/epidemiologia , Sobrepeso/epidemiologia , Paridade , Fatores de Risco , Índice de Gravidade de Doença , Fatores Sexuais , Inquéritos e Questionários , Adulto Jovem
8.
J Orthop ; 13(4): 437-442, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27857477

RESUMO

BACKGROUND: Well-fixed femoral component removal remains difficult and complicated. METHODS: We report herein the outcomes of two-stage surgery involving retention of bone-ingrown uncemented stems, aggressive soft-tissue debridement, and delayed reimplantation of an acetabular component in 5 patients for infected hip arthroplasty. RESULTS: By a mean follow-up point of 4.2 years after the second-stage operation, none of the 5 patients experienced recurrence of infection, and the mean Harris hip score had improved from 63 to 86 points by the latest follow-up evaluation. CONCLUSION: Two-stage revision with retention of well-fixed uncemented stems could be an alternative treatment option in hip periprosthetic infection.

9.
BMC Musculoskelet Disord ; 17: 320, 2016 08 02.
Artigo em Inglês | MEDLINE | ID: mdl-27484820

RESUMO

BACKGROUND: In Japan, the majority of hip osteoarthritis (OA) was caused by acetabular dysplasia, and about 90 % of patients were female. The present study focused on Japanese female patients with hip OA due to acetabular dysplasia, and examined the associated factors with OA staging at diagnosis, in special reference to body weight. METHODS: Study subjects were 336 Japanese women who were newly diagnosed with hip OA caused by acetabular dysplasia at 15 hospitals in 2008. The self-administered questionnaire elicited patients' body weight at age 20 and at OA diagnosis. Four ranked OA staging according to radiographic findings of the hip joint (pre-OA, initial stage, advanced stage or terminal stage) was regarded as the outcome index. Proportional odds models in logistic regression were used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) for severer stage of OA. RESULTS: At diagnosis, 45 % of patients suffered from terminal stage of OA, whereas 13 % and 14 % were categorized into pre-OA and initial stage, respectively. After adjustment for potential confounders, weight gain since age 20 revealed the increased ORs for severer OA stage at diagnosis (OR 2.02; 95 % CI, 1.07-3.80). Other significant characteristics were age (67+ vs. 20-49 years, OR 12.4), lower education (junior high school vs. junior college or higher, OR 4.00), parity (OR 2.19), lower acetabular head index (<60.0 vs. 71.1+, OR 2.36), and longer duration since symptom onset (6.0+ vs. <1.0 year, OR 2.94). CONCLUSIONS: Weight gain since age 20 might be involved in mechanisms of OA development, which is independent of age or severity of acetabular dysplasia.


Assuntos
Acetábulo/lesões , Luxação do Quadril/complicações , Osteoartrite do Quadril/diagnóstico , Osteoartrite do Quadril/etiologia , Aumento de Peso , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Peso Corporal , Estudos Transversais , Feminino , Articulação do Quadril/patologia , Humanos , Japão , Pessoa de Meia-Idade , Razão de Chances , Fatores de Risco , Inquéritos e Questionários , Adulto Jovem
10.
Eur J Orthop Surg Traumatol ; 26(3): 299-304, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26971327

RESUMO

There is a rising concern about squeaking in ceramic-on-ceramic total hip arthroplasty (THA). In pin-on-disc testing of a delta-delta coupling, we reproduced squeaking and observed microcracks on worn surfaces. We used a pin-on-disc machine and made discs and pins by cutting delta ceramic to a diameter of 40 mm (D-D). Cross-linked polyethylene was used for a comparison disc (D-P). We performed the same test using another D-D coupling specimen to confirm reproducibility. Squeaking in the D-D specimen was reproduced in wet conditions, though it was not found in the D-P specimen. Fast Fourier transform analysis showed a peak frequency for squeaking of 2794 Hz. The noise occurred at about 6.6 km of sliding distance. Scanning electron microscopy revealed that the worn surface of the pin in D-D at 10.8 km of sliding distance had some microcracks. However, there was no obvious damage to the worn surface of the pin in D-P at the same sliding distance. We confirmed the reproducibility of these findings, obtaining similar results, including squeaking, from another D-D coupling specimen. Our findings show that squeaking may occur in THA using delta ceramic bearings even if implants are placed to avoid extra-articular impingement of the femoral neck. Although the clinical relevance of microcracks is unknown, they may affect long-term outcomes in THA using delta ceramic bearings.


Assuntos
Prótese de Quadril/efeitos adversos , Artroplastia de Quadril/efeitos adversos , Artroplastia de Quadril/instrumentação , Artroplastia de Quadril/métodos , Cerâmica , Humanos , Microscopia Eletrônica de Varredura , Falha de Prótese/efeitos adversos , Som
11.
Int J Surg Case Rep ; 19: 154-8, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26773875

RESUMO

A 53-year-old man presented with pain in the right hip. Radiological examination showed idiopathic osteonecrosis of the femoral head (ONFH) combined with a cam lesion. Findings on physical examination were consistent for femoroacetabular impingement. At surgery, we performed isolated arthroscopic correction for the cam lesion but did not use other treatment options such as hip arthroplasty or osteotomies for the ONFH. At the latest follow-up evaluation 3 years after surgery, findings indicted a satisfactory outcome, with a Harris hip score of 93.2 (compared with 76.4 before surgery), no joint-space narrowing, and no collapse of the femoral head. It is important to accurately diagnose the status of idiopathic ONFH and to consider another possible pathogenesis when a patient with idiopathic ONFH has hip pain even without femoral-head collapse.

12.
Am J Transl Res ; 7(10): 2099-104, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26692954

RESUMO

One cause of rotator cuff tears is thought to be age-related degenerative changes occurring in the rotator cuff. Using Rat rotator cuff we determined age-related changes in mitochondrial transcription factor A (TFAM) expression in rotator cuff degeneration to clarify the presence/absence of mitochondrial stress. The materials used were rotator cuffs (supraspinatus) of 5-, 24-, 48-, and 100-week-old Wistar Rats (five animals each). Histopathological study revealed a 4-layer structure consisting of a bone layer, calcified cartilage layer, non-calcified cartilage layer, and tendinous component), with age-related narrowing of the non-calcified cartilage layer confirmed to be present. In an immunohistochemical TFAM study positive findings of the non-calcified cartilage layer were less prominent in the 100-week-old group. In an Enzyme-Linked Immunosorbent Assay (ELISA) study, these were more prominent in the 5-week-old to 24-week-old groups, and slightly less so in the 48-week-old group as compared to the 24-week-old one. In the 100-week-old group as compared to the 24-week-old one they were significantly less prominent (p<0.05). The non-calcified cartilage layer is a major site for the dispersion of mechanical energy, and the change in TFAM expression noted at the same site in the present study and the results of ELISA suggest that age-related changes in mitochondrial stress may be one cause of rotator cuff degeneration.

13.
Int J Surg Case Rep ; 14: 136-40, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26275737

RESUMO

INTRODUCTION: Although the subchondral portion of the femoral head is a common site for collapse in osteonecrosis of the femoral head (ONFH), femoral-neck fracture rarely occurs during the course of ONFH. We report a case of occult insufficiency fracture of the femoral neck without conditions predisposing to insufficiency fractures, occurring in association with ONFH. PRESENTATION OF CASE: We report a case of occult fracture of the femoral neck due to extensive ONFH in a 60-year-old man. No abnormal findings suggestive of ONFH were identified on radiographs, and the fracture occurred spontaneously without any trauma or unusual increase in activity. The patient's medical history, age, and good bone quality suggested ONFH as a possible underlying cause. Contrast-enhanced magnetic resonance imaging was useful in determining whether the fracture was caused by ONFH or was instead a simple insufficiency fracture caused by steroid use. DISCUSSION: The patient was treated with bipolar hemiarthroplasty, but if we had not suspected ONFH as a predisposing condition, the undisplaced fracture might have been treated by osteosynthesis, and this would have led to nonunion or collapse of the femoral head. To avoid providing improper treatment, clinicians should consider ONFH as a predisposing factor in pathologic fractures of the femoral neck. CONCLUSION: ONFH should be included in the differential diagnosis of insufficiency fracture of the femoral neck.

14.
Int J Clin Exp Med ; 8(3): 4718-20, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26064411

RESUMO

Coexistence of septic arthritis and gouty arthritis is rare. In particular, no reports have described the development of both gouty and septic arthritis after arthroscopic shoulder surgery. The patient was an 83-year-old man who underwent arthroscopic rotator cuff repair. He had a history of diabetes mellitus (HbA1c: 7.4%), but not of gout, and the GFR was decreased (GFR=46). During the postoperative course fever suddenly developed and joint fluid retention was found. Uric acid crystals were detected when the joint fluid was aspirated, after which when the culture results became available sepsis due to methicillin sensitive Staphylococcus aureus (MSSA) was diagnosed. On the 2(nd) day after fever onset, lavage and debridement were performed under arthroscopy, with the subsequent course uneventful with no recurrence of the infection or gouty arthritis and no joint destruction. When uric acid crystals are found in aspirated joint fluid, gouty arthritis tends to be diagnosed, but like in the present case if infection also supervenes, joint destruction and a poor general state may result if appropriate intervention is not initiated swiftly. Accordingly, even if uric acid crystals are found, the possibility of coexistence of septic arthritis and gouty arthritis should be kept in mind.

15.
J Bone Joint Surg Am ; 97(9): 726-32, 2015 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-25948519

RESUMO

BACKGROUND: We investigated the rate of conversion to total hip arthroplasty by twenty years and radiographic findings at a minimum of twenty years after rotational acetabular osteotomy. METHODS: Between June 1986 and August 1991, we performed 172 rotational acetabular osteotomies in 168 patients with acetabular dysplasia. Of those, ninety-three hips (ninety-one patients), including twenty-three hips with pre-osteoarthritis, twenty-nine with initial osteoarthritis, and forty-one with advanced osteoarthritis, had clinical and radiographic findings available. The mean age of the patients was 32.4 years (range, twelve to forty-nine years). The duration of follow-up was a mean of twenty-three years (range, twenty to twenty-seven years) for seventy-six hips, excluding hips that underwent conversion to total hip arthroplasty. RESULTS: Conversion to total hip arthroplasty by twenty years after surgery was performed in one hip (4%) with pre-osteoarthritis, two hips (7%) with initial osteoarthritis, and fourteen hips (34%) with advanced osteoarthritis. The hips with advanced osteoarthritis had a significantly higher rate of conversion to total hip arthroplasty than hips in the other stages did (p = 0.0005). At the latest follow-up or at conversion to total hip arthroplasty, the disease stage had not progressed in seventeen hips (74%) with pre-osteoarthritis, nineteen (66%) with initial osteoarthritis, and twenty-six (63%) with advanced osteoarthritis. CONCLUSIONS: The progression of osteoarthritis after rotational acetabular osteotomy was not detected for at least twenty years in most hips with either pre-osteoarthritis or initial osteoarthritis in this cohort. Rotational acetabular osteotomy may delay conversion to total hip arthroplasty in advanced osteoarthritis. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.


Assuntos
Acetábulo/cirurgia , Artroplastia de Quadril , Doenças do Desenvolvimento Ósseo/cirurgia , Osteoartrite do Quadril/cirurgia , Osteotomia/métodos , Acetábulo/patologia , Adolescente , Adulto , Assistência ao Convalescente , Criança , Progressão da Doença , Seguimentos , Humanos , Pessoa de Meia-Idade , Osteoartrite do Quadril/complicações , Fatores de Tempo
16.
Asian Spine J ; 9(1): 7-13, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25705329

RESUMO

STUDY DESIGN: Examination of hyaluronidase-4 (Hyal-4) expression in a rat spinal cord hemisection model. PURPOSE: To determine the status of Hyal-4 expression after hemisection of the spinal cord, and the relationship between its expression and that of chondroitin sulfate proteoglycans (CSPGs). OVERVIEW OF LITERATURE: CSPGs are expressed at the site of spinal cord injury and inhibit axon regeneration. Administration of exogenous chrondroitinase ABC (ChABC), derived from bacteria, digested CSPGs and promoted axonal regrowth. Using a rat hemisection model, we have demonstrated peak CSPGs levels at by 3 weeks after injury but then decreased spontaneously. Could there be an endogenous enzyme similar to ChABC in the spinal cord? It has been suggested that Hyal-4 is involved in CSPG degradation. METHODS: A rat hemisection model was prepared and spinal cord frozen sections were prepared at 4 days and 1, 2, 3, 4, 5, and 6 weeks post-cordotomy and stained for CSPGs and Hyal-4 and subjected to Western blotting. RESULTS: CSPGs appeared at the injury site at 4 days after hemisection, reached a peak after 3 weeks, and then decreased. Hyal-4 was observed around the injury site from 4 days after cordotomy and increased until after 5-6 weeks. Double staining showed Hyal-4 around CSPGs. Western blotting identified a band corresponding to Hyal-4 from 4 days after hemisection. CONCLUSIONS: Hyal-4 was expressed in a rat hemisection model in areas surrounding CSPGs, and as its peak was delayed compared with that of CSPGs. These results suggest the involvement of Hyal-4 in the digestion of CSPGs.

17.
Int J Surg Case Rep ; 8C: 13-7, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25603485

RESUMO

INTRODUCTION: The pathophysiology of rapidly destructive hip osteoarthritis (OA) of the hip is still unclear. Also, there have been only few reports on the initial stage of the disease. We report a case of an initial-stage rapidly destructive hip OA, documented by magnetic resonance imaging and intraoperative findings. PRESENTATION OF CASE: A 77-year-old woman reported left hip pain without any antecedent trauma. Initial radiographs showed no obvious abnormality. After 4 months of conservative therapy, radiographs showed progressive joint-space narrowing and T1-weighted magnetic resonance images revealed a bone-marrow edema pattern not only on the femoral head but also on the lateral side of the acetabulum. Then during total hip arthroplasty, we found extensive inversion of the anterosuperior portion of the acetabular labrum, and the location was mostly consistent with the bone-marrow edema lesions in the femoral head and acetabulum. DISCUSSION: Several theories for the etiology of rapidly destructive hip OA have been proposed, including idiopathic chondrolysis, abnormal immunoreaction, intra-articular deposition of hydroxyapatite crystals, and subchondral insufficiency fracture. One of the reasons rapidly destructive hip OA is still considered idiopathic is the lack of reports regarding the initial stage of the disease. Our report is the first to demonstrate magnetic resonance imaging for initial-stage disease with intraoperative findings before collapse of the femoral head. CONCLUSION: Inversion of the acetabular labrum may be a mechanism of rapidly destructive hip OA.

18.
Arch Orthop Trauma Surg ; 135(3): 407-15, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25577240

RESUMO

INTRODUCTION: Rotational acetabular osteotomy (RAO) has been used successfully in patients with developmental dysplasia of the hip (DDH). However, some patients are forced to undergo total hip arthroplasty (THA) because of the progression of osteoarthritis. We evaluated the effect of previous RAO on the outcome of THA performed for degenerative arthritis secondary to DDH, comparing outcomes for patients with THA and prior RAO versus outcomes for patients with THA and no prior RAO. MATERIALS AND METHODS: At an average follow-up point of 8.2 years (range 7-11 years), we compared outcomes in dysplastic hips for 22 hips (group R) in patients who underwent THA after successful RAO with outcomes for a well-matched control group of 30 hips in patients who underwent primary THA (group C) during the same period. RESULTS: Both groups had similar midterm results. No acetabular or femoral components exhibited loosening or revision in either group. Harris hip scores (HHSs) at the most recent follow-up had not been compromised by RAO, and there were no significant differences in intraoperative blood loss and operative time between the two groups. Although there was a tendency toward superolateral placement of the acetabular component in group R, there were no significant differences in the mean steady-state linear and volumetric wear rates between the two groups. There were no infections, dislocations, intraoperative fractures, damaged nerves, or deep vein thromboses in either group. CONCLUSIONS: Our midterm results demonstrated that RAO does not lead to higher revision rates, compromised HHSs, or shortened survivorship in eventual THA for DDH.


Assuntos
Acetábulo/cirurgia , Artroplastia de Quadril/métodos , Luxação Congênita de Quadril/cirurgia , Osteoartrite do Quadril/cirurgia , Osteotomia/métodos , Acetábulo/diagnóstico por imagem , Idoso , Feminino , Seguimentos , Luxação Congênita de Quadril/complicações , Luxação Congênita de Quadril/diagnóstico por imagem , Humanos , Luxações Articulares/cirurgia , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/diagnóstico por imagem , Osteoartrite do Quadril/etiologia , Radiografia , Reoperação , Estudos Retrospectivos , Rotação , Resultado do Tratamento
19.
Eur J Orthop Surg Traumatol ; 25(4): 741-7, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25556779

RESUMO

INTRODUCTION: Femoral component revisions with extensively porous-coated stems have shown promising clinical results, although there are still concerns over stress-shielding. MATERIALS AND METHODS: We retrospectively reviewed data for 18 patients undergoing femoral component revisions with extensively porous-coated stems with high stiffness. The average length of follow-up was 10 years (range 6-13.7 years). RESULTS: Radiographic evidence of a bone-ingrown stem was present in 94 % of the hips, and stable fibrous fixation was present in only one hip, but no hips were considered unstable. There was mild stress-shielding in 15 hips, moderate stress-shielding in one hip, and severe stress-shielding in two hips. In one of the latter two hips, stress-shielding was progressive even 8 years after revision surgery. In 12 (92 %) of the 13 hips in which bypass fixation for diaphyseal cortical defects was used, there was good remodeling. CONCLUSIONS: We suggest that femoral component revision using extensive porous-coated stems is a useful option that may allow for healing of diaphyseal cortical defects.


Assuntos
Artroplastia de Quadril/efeitos adversos , Doenças Ósseas/cirurgia , Remodelação Óssea/fisiologia , Diáfises/cirurgia , Fêmur/cirurgia , Adulto , Idoso , Doenças Ósseas/fisiopatologia , Materiais Revestidos Biocompatíveis , Feminino , Hemiartroplastia/efeitos adversos , Prótese de Quadril/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Fraturas Periprotéticas/fisiopatologia , Fraturas Periprotéticas/cirurgia , Porosidade , Desenho de Prótese , Falha de Prótese/efeitos adversos , Reoperação , Estudos Retrospectivos
20.
J Orthop ; 12(Suppl 1): S31-6, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26719626

RESUMO

AIMS: The aim of this study was to evaluate clinical outcomes using the Japanese Orthopaedic Association Hip-Disease Evaluation Questionnaire (JHEQ). METHODS: 100 consecutive patients at 6 months after total hip arthroplasty (THA) were evaluated. RESULTS: The improvement rate for the pain subscale was significantly higher than that for the movement and mental subscales. Preoperative scores on the JHEQ movement and mental subscales were positively correlated to scores on the same subscales at 6 months after surgery. CONCLUSION: We conclude that the most predictable aspect of THA is pain relief and preoperative hip-joint ROM and mental status influence 6-month postoperative outcomes.

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