Assuntos
Hanseníase Tuberculoide/imunologia , Mycobacterium leprae/imunologia , Fator de Necrose Tumoral alfa/imunologia , Alelos , Brasil , DNA Bacteriano/química , DNA Bacteriano/isolamento & purificação , Desoxirribonucleases de Sítio Específico do Tipo II/química , Humanos , Hanseníase Tuberculoide/genética , Mycobacterium leprae/genética , Projetos Piloto , Reação em Cadeia da Polimerase , Polimorfismo Genético/genética , Polimorfismo Genético/imunologia , Fator de Necrose Tumoral alfa/genéticaRESUMO
After the diagnosis of two cases of microsporidial intestinal infection in 1992, in Rio de Janeiro, we have started looking for this parasite in HIV-infected patients with chronic unexplained diarrhea. We have studied 13 patients from Hospital Evandro Chagas, IOC-FIOCRUZ. Fecal specimens from these patients were examined for the presence of Cryptosporidia and Microsporidia, in addition to routine examination. Spores of Microsporidia were found in the stools of 6 (46.1%) of the 13 patients studied, with 2 histological jejunal confirmations. The Microsporidia-infected patients presented chronic diarrhea with about 6 loose to watery bowel movements a day. Five infected patients were treated with Metronidazole (1.5 g/day). They initially showed a good clinical response, but they never stopped eliminating spores. After about the 4th week of therapy, their diarrhea returned. Two patients utilized Albendazole (400 mg/day-4 weeks) with a similar initial improvement and recurrence of the diarrhea. Intestinal Microsporidiosis seems to be a marker of advanced stages of AIDS, since 5 of our 6 infected patients were dead after a 6 month period of follow-up. The present study indicates that intestinal microsporidiosis may be a burgeoning problem in HIV-infected patients with chronic diarrhea in Brazil, which deserves further investigation.
Assuntos
Diarreia/etiologia , Enteropatia por HIV/complicações , Microsporidiose/complicações , Adulto , Albendazol/uso terapêutico , Animais , Antiprotozoários/uso terapêutico , Brasil , Doença Crônica , Fezes/parasitologia , Feminino , Seguimentos , Enteropatia por HIV/diagnóstico , Enteropatia por HIV/tratamento farmacológico , Humanos , Jejuno/parasitologia , Masculino , Metronidazol/uso terapêutico , Microsporidiose/diagnóstico , Microsporidiose/tratamento farmacológico , Pessoa de Meia-Idade , Estudos Prospectivos , RecidivaRESUMO
Synopsis The aim of this work was to evaluate several plant extracts with regard to ultraviolet absorption spectra in view of a possible application as antisolar agents. Liquid and dry extracts of Hamamelis virginiana, Matricaria recutita, Aesculus hippocastanum, Rhamnus purshiana and Cinnamomum zeylanicum were prepared by repercolation, maceration and microwave oven extraction. UVB absorption spectra (290-320nm) were obtained and the solar protection factors (SPF) of these preparations were determined by a spectrophotometric method. The results showed that after incorporation to a 2% solution of the synthetic sunscreen octylmethoxycinnamate, the extracts showed an intensification in SPF values, suggesting that this can be an interesting method to intensify SPF. In addition, these extracts can contribute their emollient and moistening properties to the product. These are important characteristics for protecting skin against exposure to the sun.
RESUMO
A partir de uma experiencia no Setor de Interconsultas do Ambulatorio de Saude Mental do Hospital de Clinicas da UFRJ, e feita uma discussao critica dos trabalhos de Balint, na Inglaterra, e Ferrari e Luchina, na Argentina. Sao narrados tres casos de "interconsultoria" solicitados pelas clinicas do hospital, comentando-se a forma de atuacao da equipe. Constata-se na atualidade, a implantacao de uma medicina psicologizada que preconiza os dispositivos psiquiatricos para toda a pratica medica, com base no saber psicanalitico, minimizando a demarcacao entre o normal e o patologico e conferindo ao psiquiatra/ psicoterapeuta o poder de intervencao interpretativa a todo ato medico