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Chemistry ; 30(31): e202400009, 2024 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-38446718

RESUMO

An effective, GFP-inspired fluorescent Zn2+ sensor is developed for two-photon microscopy and related biological application that features an 8-methoxyquinoline moiety. Excellent photophysical characteristics including a 37-fold fluorescence enhancement with excitation and emission maxima at 440 nm and 505 nm, respectively, as well as a high two-photon cross-section of 73 GM at 880 nm are reported. Based on the experimental data, the relationship between the structure and properties was elucidated and explained backed up by DFT calculations, particularly the observed PeT phenomenon for the turn-on process. Biological validation and detailed experimental and theoretical characterization of the free and the zinc-bound compounds are presented.


Assuntos
Corantes Fluorescentes , Proteínas de Fluorescência Verde , Quinolinas , Zinco , Zinco/química , Corantes Fluorescentes/química , Quinolinas/química , Proteínas de Fluorescência Verde/química , Humanos , Teoria da Densidade Funcional , Microscopia de Fluorescência por Excitação Multifotônica/métodos , Fótons
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