RESUMO
An unusual fatality involving a 26-year-old male who intentionally ingested approximately 10 g of metoprolol is presented. Autopsy findings revealed foreign material in the gastric content with an acute thrombosis of the left anterior descending coronary artery. Microscopic studies showed evidence of an extremely early infarct. Metoprolol concentrations in the blood, liver, gastric content, and urine are reported by both capillary gas chromatography and ultraviolet spectrophotometric analysis. A review of the literature confirmed that little information has been published concerning intoxication with this drug.
Assuntos
Metoprolol/intoxicação , Suicídio , Adulto , Cromatografia Gasosa , Doença das Coronárias/patologia , Humanos , Masculino , Metoprolol/análise , Miocárdio/patologia , Espectrofotometria UltravioletaRESUMO
A 27-year-old male died as the result of swallowing a bag of cocaine. Using gas chromatography and ultraviolet spectrophotometry, the concentration of cocaine was determined on all specimens submitted for analysis. These analyses revealed what may possibly be the highest concentrations of cocaine ever reported in the toxicology literature. These values were confirmed by another medical examiner toxicology laboratory.
Assuntos
Cocaína/intoxicação , Morte Súbita/etiologia , Adulto , Cromatografia Gasosa , Cocaína/sangue , Humanos , Masculino , Espectrofotometria UltravioletaRESUMO
An arsenic death was investigated six and one half years after the demise. Analysis of tissue embedded in paraffin blocks demonstrated toxic concentrations. Spectrophotometry was employed with the use of a hydride generator to provide specificity and sensitivity to less than 0.05 microgram.
