Antioxidant and antiproliferative activities of n-hexane extract and its fractions from Blumea balsamifera L. leaves.

Blumea balsamifera is a plant species that has been popularly used to treat a broad spectrum of diseases. In efforts of tackling the increasing threat of cancers, B. balsamifera has been studied for its anticancer potentials. Hence, through this research, we aimed to evaluate the antioxidant and antiproliferative activities of n-hexane extract from B. balsamifera L. leaves along with its fractionation products. After the n-hexane extract has been obtained, the sample was column chromatographed using gradient elution with n-hexane:ethyl acetate solvent. All the isolation protocols produced 1 n-hexane extract and 10 different fractions (fractions 1-10). Antioxidant and antiproliferative effects of the samples were assessed based on 2,2-diphenyl-1-picrylhydrazyl and brine shrimp lethality test assay, respectively. None of the samples have a strong antioxidant level because all samples yielded IC50 of more than 100 ppm - the best of them was fraction 8 with IC50 = 113.716 ppm. On contrary, most of the samples were observed to have a potent antiproliferative effect, especially fraction 8 with LC50 = 2.00 ppm. Taken altogether, fraction 8 from the n-hexane extract of B. balsamifera L. leaves is the most potential candidate for proliferative disease therapy, where further studies confirming the results are required.

Multinuclear palladium(II) complexes from P-C and P-Cl bond cleavage in (R(P),R(P)/S(P),S(P))-[PdCl2{1,2-(P(t)BuCl)2C2B10H10}].

Two multinuclear palladium(II) complexes have been isolated as decomposition products resulting from P-Cl and P-C bond cleavage in (R(P),R(P)/S(P),S(P))-[PdCl(2){1,2-(P(t)BuCl)(2)C(2)B(10)H(10)}] in dichloromethane.

Platinum(II) and palladium(II) complexes of chiral P-Cl functionalized bis-phosphino ortho-carbaboranes.

Platinum(II) and palladium(II) complexes of chiral P-Cl functionalized bis-phosphino ortho-carbaborane are readily obtained from reactions of chiral bidentate phosphino carbaborane ligands rac-1,2-(PRCl)(2)(C(2)B(10)H(10)) with [MCl(2)(COD)] (M = Pd, Pt; COD = 1,5-cyclooctadiene) to give cis-rac-[MCl(2){1,2-(PRCl)(2)(C(2)B(10)H(10))}] (M = Pt, Pd; R = (t)Bu, Ph, NEt(2), NPh(2)). cis-rac-[MCl(2){1,2-(P(t)BuCl)(2)(C(2)B(10)H(10))}] [M = Pt (1), Pd (6)] decompose in solution in toluene or dichloromethane at room temperature over several weeks with formation of the corresponding dinuclear platinum and palladium complex with two nido-carbaboranyl phosphine ligands, (R(P),R(P),S(P),S(P))-[{M(7,8-{P(t)BuCl}(2)C(2)B(9)H(10))(mu-Cl)}(2)] [M = Pt (2), Pd (7)], among other decomposition products.

Synthesis and reactivity of ortho-carbaborane-containing chiral aminohalophosphines.

The synthesis of chiral ortho-carbaboranyl bis(aminohalophosphines) is presented, and spectroscopic and crystallographic data of these compounds are discussed. Furthermore, their reactivity toward alcoholysis was investigated. Quantum chemical calculations showed that the inhibition of methanolysis is of kinetic and not of thermodynamic origin. The disubstitution of the carbaboranes leads to P...P interactions as strong as a hydrogen bond that extremely lower the rate of the methanolysis.