RESUMO
A cacalolide derivative named 4alpha-[2'-hydroxymethylacryloxy]-1beta-hydroxy-14-(5-->6) abeo eremophilan-12,8-olide and a shikimic acid derivative named (3'E)-(1alpha)-3-hydroxymethyl-4beta,5alpha-dimethoxycyclohex-2-enyloctadec-3'-enoate along with three known compounds, octacosan-1-ol, 3beta-hydroxyolean-12-en-28-oic acid and 3beta-acetoxyolean-12-en-28-oic acid were isolated from Senecio burtonii. Their structures and relative configurations were established on the basis of spectroscopic analysis.
Assuntos
Naftalenos/isolamento & purificação , Senécio/química , Ácido Chiquímico/análogos & derivados , Estrutura Molecular , Naftalenos/química , Estruturas Vegetais/química , Ácido Chiquímico/química , Ácido Chiquímico/isolamento & purificaçãoRESUMO
In addition to one known compound, 3beta,8alpha-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (8-desacylcynaropicrin) (3), two new sesquiterpene lactones have been isolated from the aerial parts of Crepis cameroonica. By means of spectroscopic analysis, the structures and relative configurations of the new compounds were established as 3beta,9beta-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (1) and 8alpha-hydroxy-4alpha(13),11beta(15)-tetrahydrozaluzanin C (2). The in vitro antimicrobial spectrum of pure compounds and crude extracts are also reported.
Assuntos
Antibacterianos/farmacologia , Crepis , Fitoterapia , Extratos Vegetais/farmacologia , Antibacterianos/administração & dosagem , Antibacterianos/química , Antibacterianos/uso terapêutico , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Humanos , Lactonas/administração & dosagem , Lactonas/química , Lactonas/farmacologia , Lactonas/uso terapêutico , Testes de Sensibilidade Microbiana , Componentes Aéreos da Planta , Extratos Vegetais/administração & dosagem , Extratos Vegetais/química , Extratos Vegetais/uso terapêutico , Sesquiterpenos/administração & dosagem , Sesquiterpenos/química , Sesquiterpenos/farmacologia , Sesquiterpenos/uso terapêuticoRESUMO
Methanol, ethyl acetate, and hexane extracts of Bridelia ferruginea leaves exhibited significant activity against Pseudomonas frutescens, Bacillus subtilis, Echerichia coli, Staphylococcus aureus and Streptococcus faecalis.
Assuntos
Antibacterianos/farmacologia , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Fitoterapia , Extratos Vegetais/farmacologia , Plantas Medicinais , Camarões , Humanos , Medicinas Tradicionais Africanas , Testes de Sensibilidade Microbiana , Folhas de PlantaRESUMO
Three new isoflavonoids, griffonianone A (1), B (2) and C (4) were isolated from the root bark of Millettia griffoniana, along with the known maximaisoflavone G (5) and 7-hydroxy-6-methoxy-3',4'-methylenedioxyisoflavone (6). Their structures were assigned on the basis of spectroscopic data and chemical transformations.
Assuntos
Fabaceae/química , Isoflavonas/isolamento & purificação , Plantas Medicinais , Isoflavonas/química , Espectroscopia de Ressonância Magnética , Raízes de Plantas/químicaRESUMO
Sigmoidin F, a new prenylated flavanone, as well as abyssinone IV and 5,7,4'-trihydroxy-3'-methoxy-5'-(1"-prenyl) flavonone have been isolated from the stem and bark of Erythrina sigmoidea. The structure of 1 has been confirmed by a combination of 1H-nmr and other spectroscopic techniques.
Assuntos
Erythrina/análise , Flavonoides/isolamento & purificação , Plantas Medicinais/análise , Terpenos/isolamento & purificação , Estrutura Molecular , Análise EspectralRESUMO
Garcinia epuctata is an indigenous medicinal plant of Cameroon from which taxifolin 6-C-glucoside was isolated and characterized. The nmr assignments obtained from COSY and INAPT experiments are reported for the first time.