Comparison of semantic and phonological false memories in short- and long-term tests.

The Deese-Roediger-McDermott (DRM) paradigm has been at the centre of false memory research. Whereas most work with this paradigm has examined memory at the long term and with semantically associated lists, the present study examines phonological and semantic false memories at both short- and long-term delays. In two experiments, participants studied short lists containing six (Experiment 1) or four (Experiment 2) items, either semantically or phonologically related to the same non-studied critical items (CI). Following each list, participants completed 36 trials of an immediate recognition task (short-term memory [STM]-only condition) only or they also completed a surprise recognition test after a 1-min delay after all 36 STM trials (STM + long-term memory [LTM] condition). In STM, false alarms were higher in phonological lists, whereas after the delay, false alarms were higher in semantic lists, reflecting differential sensitivity to the type of association as a function of delay. A third experiment examined LTM performance after controlling for prior testing and yielded highly similar results. Both the activation-monitoring framework (AMF) and fuzzy-trace theory (FTT) can explain the majority of the findings, with some remaining issues. These results confirm that information from the knowledge base (LTM) does influence accuracy in an STM task, albeit less so than perceptual level similarity.

Service Providers' Perspectives: Reducing Intimate Partner Violence in Rural and Northern Regions of Canada.

BACKGROUND: Intimate partner violence (IPV) persists as a serious challenge, globally, with regions in Central and Northern Canada reporting the highest rates of shelter use to escape abuse, of sexual assault, and of IPV in the country. Despite research into IPV, barriers and gaps exist in understanding what an effective response to IPV in rural and northern communities should look like. METHODS: To enhance this understanding, qualitative interviews and focus groups with a total of 55 participants were conducted with service providers, including shelter services, victims services, the Royal Canadian Mounted Police, counselors, and others (e.g., psychologists). A grounded theory approach was used to analyze data, with findings illustrated in a schematic that conceptualize the challenges service providers experience. RESULTS: The findings reveal how an IPV environment, characterized by oppression, abuse, and illness, requires transformation into an IPV-free environment, characterized by empowerment, positive social connections, and wellness. As service providers work to influence this transition, they become experts in understanding the sociocultural context, formal services, and informal supports accessible or not for women experiencing IPV. Service providers encourage social media use into service delivery to improve communication; lobby for rural-specific IPV specialists; and recognize isolation as a barrier to seeking out safe shelter and housing, transportation, and economic assistance. CONCLUSION: In order to reduce rates of IPV, the results suggest we must support service providers, document service gaps, and maximize policy change and community action based on IPV as it is experienced in rural and northern regions of Canada.

Manipulations of List Type in the DRM Paradigm: A Review of How Structural and Conceptual Similarity Affect False Memory.

The use of list-learning paradigms to explore false memory has revealed several critical findings about the contributions of similarity and relatedness in memory phenomena more broadly. Characterizing the nature of "similarity and relatedness" can inform researchers about factors contributing to memory distortions and about the underlying associative and semantic networks that support veridical memory. Similarity can be defined in terms of semantic properties (e.g., shared conceptual and taxonomic features), lexical/associative properties (e.g., shared connections in associative networks), or structural properties (e.g., shared orthographic or phonological features). By manipulating the type of list and its relationship to a non-studied critical item, we review the effects of these types of similarity on veridical and false memory. All forms of similarity reviewed here result in reliable error rates and the effects on veridical memory are variable. The results across a variety of paradigms and tests provide partial support for a number of theoretical explanations of false memory phenomena, but none of the theories readily account for all results.

Comparing costs in time-based and event-based prospective memory.

Although much recent research has focused on event-based prospective memory (PM), fewer studies have compared event- and time-based PM. In the current study, two experiments were conducted to directly compare ongoing task costs of focal and non-focal event-based tasks with a time-based task. In the second experiment, an external reminder of the task was present to test whether this reduced the cost of the time-based task. PM accuracy was significantly greater for the focal conditions, as predicted. Response times (RT) were highest in the non-focal tasks, with similar RTs in the focal and time-based tasks. Clock check frequency was significantly related to making a PM response in the time-based task, with clock checks increasing as the 7 min target time approached. While time-based tasks may be more difficult to complete, they do not seem to result in the speed cost to an ongoing task that non-focal PM tasks do.

The feature boost in false memory: the roles of monitoring and critical item identifiability.

The feature boost refers to increased false memories for word lists that are both associatively and categorically (C + A) related to a non-presented critical item (CI) relative to lists that are only associatively (NC-A) related [Coane, J. H., McBride, D. M., Termonen, M.-L., & Cutting, J. C. (2016). Categorical and associative relations increase false memory relative to purely associative relations. Memory & Cognition, 44(1), 37-49. doi:10.3758/s13421-015-0543-1]. We explored the replicability of the feature boost and its dependance on monitoring processes by explicitly warning participants about the nature of the lists or by asking participants to guess the CI (implicit warning). Overall, the feature boost was replicated. Guessing performance was higher for C + A lists than for NC-A lists. Explicit warnings were equally effective for both list types in reducing false memory relative to recall and to a no-recall math condition. When the CI was not guessed or recalled, the feature boost emerged. However, when the CI was guessed or previously recalled, false alarms did not differ as a function of list type. The feature boost seems to be driven in part by differences in the identifiability of the CI, such that CIs related to C + A lists are harder to identify and thus reject. These results suggest that differences in monitoring processes that are sensitive to CI identifiability contribute to the effect.

E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer.

BACKGROUND: We previously reported the presence of prostate-specific antigen (PSA) in the stromal compartment of benign prostatic hyperplasia (BPH). Since PSA is expressed exclusively by prostatic luminal epithelial cells, PSA in the BPH stroma suggests increased tissue permeability and the compromise of epithelial barrier integrity. E-cadherin, an important adherens junction component and tight junction regulator, is known to exhibit downregulation in BPH. These observations suggest that the prostate epithelial barrier is disrupted in BPH and E-cadherin downregulation may increase epithelial barrier permeability. METHODS: The ultra-structure of cellular junctions in BPH specimens was observed using transmission electron microscopy (TEM) and E-cadherin immunostaining analysis was performed on BPH and normal adjacent specimens from BPH patients. In vitro cell line studies using benign prostatic epithelial cell lines were performed to determine the impact of small interfering RNA knockdown of E-cadherin on transepithelial electrical resistance and diffusion of fluorescein isothiocyanate (FITC)-dextran in transwell assays. RESULTS: The number of kiss points in tight junctions was reduced in BPH epithelial cells as compared with the normal adjacent prostate. Immunostaining confirmed E-cadherin downregulation and revealed a discontinuous E-cadherin staining pattern in BPH specimens. E-cadherin knockdown increased monolayer permeability and disrupted tight junction formation without affecting cell density. CONCLUSIONS: Our results indicate that tight junctions are compromised in BPH and loss of E-cadherin is potentially an important underlying mechanism, suggesting targeting E-cadherin loss could be a potential approach to prevent or treat BPH.

Short-term false memories vary as a function of list type.

False memories have primarily been investigated at long-term delays in the Deese-Roediger-McDermott (DRM) procedure, but a few studies have reported meaning-based false memories at delays as short as 1-4 s. The current study further investigated the processes that contribute to short-term false memories with semantic and phonological lists (Experiment 1) and hybrid lists containing items of each type (Experiment 2). In Experiment 1, more false memories were found for phonological than for semantic lists. In Experiment 2, an asymmetrical hyper-additive effect was found such that including one or two phonological associates in pure semantic lists yielded a robust increase in false alarms, whereas including semantic associates in pure phonological lists did not affect false alarms. These results are more consistent with the activation-monitoring account of false memory creation than with fuzzy trace theory that has not typically been referenced when describing phonological false memories.

Task order choices in cognitive and perceptual-motor tasks: The cognitive-load-reduction (CLEAR) hypothesis.

A core question in the study of the dynamics of cognition is how tasks are ordered. Given two tasks, neither of which is prerequisite for the other and neither of which brings a clearly greater reward, which task will be done first? Few studies have addressed this question, though recent work has suggested one possible answer, which we here call the cognitive-load-reduction (CLEAR) hypothesis. According to the CLEAR hypothesis, there is a strong drive to reduce cognitive load (to "clear one's mind"). Given two tasks, one of which is more cognitively demanding than the other, the more cognitively demanding task will tend to be done first. We tested this prediction using a novel method inviting participants to freely choose when to perform each of c = 5, 10, or 15 items per category in item-generation tasks relative to b = 10 box-moving tasks. The box-moving tasks were cognitively undemanding relative to the item generation tasks, whose cognitive difficulty presumably grew with c. A full half of our n = 122 participants chose to complete all of the c tasks before performing any of the b tasks, and most other participants chose to complete a majority of the c tasks before any of the b tasks. This result is consistent with the CLEAR hypothesis. Speed on the box-moving task decreased the later the category-generation task was completed, supporting another CLEAR prediction. The general method used here provides direction for future work on task order choices in cognitive and perceptual-motor tasks.

Comparing time-based and event-based prospective memory over short delays.

The current study compared monitoring in time- and event-based prospective memory (PM). Time- and event-based non-focal task instructions were given after a baseline block of a lexical decision ongoing task. Delay between instruction and presentation of PM cue/time was manipulated between-subjects to examine monitoring across short delays (1-6 min). Longer delays decreased performance in the event-based task, but not in the time-based task. This accuracy decline was accompanied by a decline in monitoring (as measured by PM cost to the ongoing task in the trials immediately before the PM cue was presented) between the 1 and 3 min delays. Monitoring was only evident for the time-based task at the 6 min delay as measured by PM cost to the ongoing task. Clock checks were also not affected by delay, but did increase in frequency as the response time neared. These results suggest that delay from the time of intention formation decreases both accuracy and monitoring in event-based tasks, but does not decrease accuracy or monitoring in time-based tasks.

Perceiving and Remembering Affordances for Others Are Continuous Processes.

In information-based approaches, affordances are perceived by detecting information that specifies an animal-environment fit, not by combining perceptions of constituent lower-order properties. Given that detection of such information necessarily occurs over space and time, there is no clear distinction between perception and memory. Rather, perceiving and remembering are continuous processes. Whereas previous research has investigated the continuity of perceived and remembered affordances for the self, we did so with respect to perceived and remembered affordances for others. Participants reported remembered maximum reaching height and remembered anthropometric properties of another person. Remembered maximum reaching height was not reducible to a combination of remembered anthropometric properties. Moreover, remembered maximum reaching height scaled to the reaching ability of the other person and not to that of the perceiver. Both results are consistent with an information-based perspective on perceiving and remembering affordances and demonstrate a continuity between perceiving and remembering affordances for others.

Preoperative immunonutrition prior to radical cystectomy: a pilot study.

INTRODUCTION: To investigate the use of a high-arginine immunonutrient supplement prior to radical cystectomy for bladder cancer. MATERIALS AND METHODS: We recruited 40 patients to consume a total of four high-arginine immunonutrient shakes per day for 5 days prior to radical cystectomy. The primary outcome measures were safety, tolerability and adherence to the supplementation regimen. Ninety-day postoperative outcomes were also compared between supplemented patients and a cohort of 104 prospectively identified non-supplemented radical cystectomy patients. Multivariable logistic regression models were used to compare overall complications, infectious complications, and readmission rates between groups. RESULTS: There were no serious adverse events during supplementation. Four patients (10%) stopped supplementation due to nausea (n = 2) and bloating (n = 2). Thirty-three patients (83%) consumed all prescribed shakes. Immunonutrient supplementation was not significantly associated with overall complications (adjusted odds ratio [OR] 1.08; 95% confidence interval [CI] 0.50-2.33), infectious complications (OR 1.23; 95% CI 0.49-3.07), or readmissions (OR 1.48; 95% CI 0.62-3.51) on multivariable analyses. CONCLUSIONS: Preoperative supplementation with a high-arginine immunonutrient shake was safe and well tolerated prior to radical cystectomy. Contrary to prior reports, immunonutrient supplementation was not associated with lower postoperative infectious complications in this cohort, perhaps owing to the 5 day supplementation period. Further study is needed to identify the optimal immunonutrient supplement regimen for radical cystectomy patients.

The effect of semantic context on prospective memory performance.

The current study provides evidence for spontaneous processing in prospective memory (PM) or memory for intentions. Discrepancy-plus-search is the spontaneous processing of PM cues via disruptions in processing fluency of ongoing task items. We tested whether this mechanism can be demonstrated in an ongoing rating task with a dominant semantic context. Ongoing task items were manipulated such that the PM cues were members of a semantic category (i.e., Body Parts) that was congruent or discrepant with the dominant semantic category in the ongoing task. Results showed that participants correctly responded to more PM cues when there was a category discrepancy between the PM cues and ongoing task items. Moreover, participants' identification of PM cues was accompanied by faster ongoing task reaction times when PM cues were discrepant with ongoing task items than when they were congruent. These results suggest that a discrepancy-plus-search process supports PM retrieval in certain contexts, and that some discrepancy-plus-search mechanisms may result from the violation of processing expectations within a semantic context.

Categorical and associative relations increase false memory relative to purely associative relations.

The goal of the present study was to examine the contributions of associative strength and similarity in terms of shared features to the production of false memories in the Deese/Roediger-McDermott list-learning paradigm. Whereas the activation/monitoring account suggests that false memories are driven by automatic associative activation from list items to nonpresented lures, combined with errors in source monitoring, other accounts (e.g., fuzzy trace theory, global-matching models) emphasize the importance of semantic-level similarity, and thus predict that shared features between list and lure items will increase false memory. Participants studied lists of nine items related to a nonpresented lure. Half of the lists consisted of items that were associated but did not share features with the lure, and the other half included items that were equally associated but also shared features with the lure (in many cases, these were taxonomically related items). The two types of lists were carefully matched in terms of a variety of lexical and semantic factors, and the same lures were used across list types. In two experiments, false recognition of the critical lures was greater following the study of lists that shared features with the critical lure, suggesting that similarity at a categorical or taxonomic level contributes to false memory above and beyond associative strength. We refer to this phenomenon as a "feature boost" that reflects additive effects of shared meaning and association strength and is generally consistent with accounts of false memory that have emphasized thematic or feature-level similarity among studied and nonstudied representations.

Response dynamics in prospective memory.

Prospective memory (PM) is the ability to remember to execute a delayed behavior. Most theoretical and empirical work on PM has focused on the attentional resources that might facilitate successfully executing a delayed behavior. In the present study, we enhance the current understanding of attention allocation and also introduce novel evidence for the dynamics of PM retrieval. We recorded mouse-tracking trajectories during a prospective memory task to examine the continuous nature of attentional processes that support PM cue retrieval. We found that the velocity profiles of response trajectories differed as a function of PM cue focality while controlling for the canonical measure of response time, supporting the notions that monitoring is evident in the continuous nature of response trajectories and that such trajectories are sensitive to cue focality. Conditional velocity profiles of ongoing task trials indicated that monitoring occurred when the processing of PM cues differed from ongoing task instructions (Nonfocal PM condition): responses were made later in the profile, suggestive of a more controlled retrieval process. Analysis of PM cue retrieval profiles indicated correctly retrieved Focal PM cues were qualitatively and quantitatively different from all other PM cue retrieval trials. This provides evidence that retrieval dynamics of a delayed behavior differ as a function of cue focality and suggests that controlled processing may contribute to spontaneous retrieval of a PM task.

Interactive effects in transfer-appropriate processing for event-based prospective memory: the roles of effort, ongoing task, and PM cue properties.

Past studies (e.g., Marsh, Hicks, & Cook Journal of Experimental Psychology: Learning, Memory, and Cognition 31:68-75, 2005; Meiser & Schult European Journal of Cognitive Psychology 20:290-311, 2008) have shown that transfer-appropriate processing (TAP) effects in event-based prospective memory (PM) depend on the effort directed toward the ongoing task. In the present study, we addressed mixed findings from these studies and examined monitoring in TAP and transfer-inappropriate processing (TIP) conditions. In two experiments, a semantic or orthographic ongoing task was paired with a PM cue that either was matched in processing (TAP) or did not match in processing (TIP). Within each condition, effort was varied across trials. The results indicated that PM accuracy was higher in TAP than in TIP conditions, regardless of effort condition, supporting the findings reported by Meiser and Schult. Ex-Gaussian functions were fit to the mean reaction times (cf. Brewer Journal of Psychology 219:117-124, 2011) in order to examine monitoring across conditions. The analysis of distributional skew (τ parameter) showed sensitivity to ongoing task instructions and properties of the PM cues. These results support Meiser and Schult's suggestion that TIP conditions require more attentional processing, and they also afford novel discussion on the interactive effects of ongoing task condition, PM cue properties, and manipulations of effort.

A test of the survival processing advantage in implicit and explicit memory tests.

The present study was designed to investigate the survival processing effect (Nairne, Thompson, & Pandeirada, Journal of Experimental Psychology: Learning, Memory, and Cognition, 33, 263-273, 2007) in cued implicit and explicit memory tests. The survival effect has been well established in explicit free recall and recognition tests, but has not been evident in implicit memory tests or in cued explicit tests. In Experiment 1 of the present study, we tested implicit and explicit memory for words studied in survival, moving, or pleasantness contexts in stem completion tests. In Experiment 2, we further tested these effects in implicit and explicit category production tests. Across the two experiments, with four separate memory tasks that included a total of 525 subjects, no survival processing advantage was found, replicating the results from implicit tests reported by Tse and Altarriba (Memory & Cognition, 38, 1110-1121, 2010). Thus, although the survival effect appears to be quite robust in free recall and recognition tests, it has not been replicated in cued implicit and explicit memory tests. The similar results found for the implicit and explicit tests in the present study do not support encoding elaboration explanations of the survival processing effect.

Differential effects of delay on time-based prospective memory in younger and older adults.

The current study measured forgetting in a time-based, naturalistic prospective memory (PM) task. In Experiment 1, younger and older participants were asked to mail a stamped postcard on a date that was delayed 1, 2, 5, 14, or 28 days in the future. In Experiment 2, a different sample of older participants completed the same task with similar delays to replicate results for the older sample in Experiment 1. Overall, older participants were more likely than younger participants to mail the postcard on time. In addition, delay affected on-time return rates more for the younger participants than the older participants. Younger participants' return rates illustrated the typical forgetting curve seen in numerous retrospective memory studies (i.e., rapid decline at shorter delays and slower decline for longer delays). However, older participants' return rates only declined at the longest delays. These results indicate that time-based PM performance declines with an increase in delay, but the form of the decline may differ across age groups.

A comparison of transfer-appropriate processing and multi-process frameworks for prospective memory performance.

We examined multi-process (MP) and transfer-appropriate processing descriptions of prospective memory (PM). Three conditions were compared that varied the overlap in processing type (perceptual/conceptual) between the ongoing and PM tasks such that two conditions involved a match of perceptual processing and one condition involved a mismatch in processing (conceptual ongoing task/perceptual PM task). One of the matched processing conditions also created a focal PM task, whereas the other two conditions were considered non-focal (Einstein & McDaniel, 2005). PM task accuracy and ongoing task completion speed in baseline and PM task conditions were measured. Accuracy results indicated a higher PM task completion rate for the focal condition than the non-focal conditions, a finding that is consistent with predictions made by the MP view. However, reaction time (RT) analyses indicated that PM task cost did not differ across conditions when practice effects are considered. Thus, the PM accuracy results are consistent with a MP description of PM, but RT results did not support the MP view predictions regarding PM cost.

Enhanced control of pathogenic Simian immunodeficiency virus SIVmac239 replication in macaques immunized with an interleukin-12 plasmid and a DNA prime-viral vector boost vaccine regimen.

DNA priming has previously been shown to elicit augmented immune responses when administered by electroporation (EP) or codelivered with a plasmid encoding interleukin-12 (pIL-12). We hypothesized that the efficacy of a DNA prime and recombinant adenovirus 5 boost vaccination regimen (DNA/rAd5) would be improved when incorporating these vaccination strategies into the DNA priming phase, as determined by pathogenic simian immunodeficiency virus SIVmac239 challenge outcome. The whole SIVmac239 proteome was delivered in 5 separate DNA plasmids (pDNA-SIV) by EP with or without pIL-12, followed by boosting 4 months later with corresponding rAd5-SIV vaccine vectors. Remarkably, after repeated low-dose SIVmac239 mucosal challenge, we demonstrate 2.6 and 4.4 log reductions of the median SIV peak and set point viral loads in rhesus macaques (RMs) that received pDNA-SIV by EP with pIL-12 compared to the median peak and set point viral loads in mock-immunized controls (P < 0.01). In 5 out of 6 infected RMs, strong suppression of viremia was observed, with intermittent "blips" in virus replication. In 2 RMs, we could not detect the presence of SIV RNA in tissue and lymph nodes, even after 13 viral challenges. RMs immunized without pIL-12 demonstrated a typical maximum of 1.5 log reduction in virus load. There was no significant difference in the overall magnitude of SIV-specific antibodies or CD8 T-cell responses between groups; however, pDNA delivery by EP with pIL-12 induced a greater magnitude of SIV-specific CD4 T cells that produced multiple cytokines. This vaccine strategy is relevant for existing vaccine candidates entering clinical evaluation, and this model may provide insights into control of retrovirus replication.

Effects of delay of prospective memory cues in an ongoing task on prospective memory task performance.

To address the mixed results reported in previous studies, the present experiments examined forgetting in prospective memory (PM) by manipulating the delay between the PM instructions and cue presentation in event-based PM tasks. PM performance was measured for delays of 2-20 min in Experiment 1 and for delays of approximately 1-10 min in Experiment 2. Experiment 2 included both focal and nonfocal PM tasks, and speed on the ongoing task was measured to examine evidence for monitoring processes across the delays tested. The results suggest that nonfocal PM performance follows a nonlinear forgetting function (i.e., rapid decline for shorter delays and slower decline for longer delays) when tested over delays from 1 to 20 min. No effect of delay was seen for the focal task tested in Experiment 2 from 1 to 10 min. In Experiment 2, ongoing-task costs were also found for the first delay but not for longer delays, suggesting that monitoring was significantly reduced between 1 and 2.5 min of the ongoing-task trials.