RESUMO
Graphs and tables published 10 years ago in our Clinical Kidney Transplants 1985 book are compared to current analyses. Impressive progress is apparent over the past decade. During this period, the effects of factors such as transfusion and the duration of first grafts on second grafts have disappeared, while the effects of factors such as cold ischemia time, regrafts and original disease have diminished in magnitude. Other factors, including HLA matching, donor age and race, continue to exhibit significant influence. It should be emphasized that most of these comparisons apply to one-year graft survival. Thus, our attention must now turn to factors which influence 10-year graft survival. Though 10 years is considered long-term survival to transplant physicians, for patients, it is but a brief period of life.
Assuntos
Transplante de Rim/tendências , Adolescente , Adulto , Fatores Etários , California , Criança , Pré-Escolar , Feminino , Sobrevivência de Enxerto , Antígenos HLA , Humanos , Lactente , Nefropatias/cirurgia , Transplante de Rim/imunologia , Transplante de Rim/estatística & dados numéricos , Doadores Vivos , Masculino , Pessoa de Meia-Idade , Preservação de Órgãos , Sistema de Registros , Reoperação , Fatores Sexuais , Doadores de TecidosRESUMO
Leukemia cells from 13 of 27 patients stimulated lymphocytes of their HLA-identical siblings in mixed leukocyte cultures (MLC). Stimulation correlated with high background uptake of tritiated thymidine and high percentages of cells that stained with fluorescein-conjugated polyvalent goat antiserum against human immunoglobulin. Results were similar to those reported with fractionated autologous lymphocyte subpopulations in normal individuals. Investigation of leukemia-specific stimulation in MLC is therefore problematic.
