[Seronegative symmetrical synovitis with edema in both hands in patient with central cord injury]. / Sinovitis simétrica seronegativa con edema en ambas manos en paciente con lesión centromedular.

A 55-year-old man with post-traumatic central cord injury, diagnosed with remitting seronegative symmetrical synovitis with pitting edema (RS3PE syndrome). The clinical picture begins with an acute pain in hands, swelling and stiffness. The physical examination revealed edema with fovea on the back of both hands, with pain and swelling in the metacarpophalangeal joints. Given this, different analytical tests and radiography of hands were requested. We started treatment with 30mg of prednisone, showing significant clinical improvement, disappearing arthritis and edema, and normalization of the analytical values. The peculiarity of presentation of RS3PE syndrome in a patient with a central cord injury is due to the difficulty of identifying it due to the superposition of clinical manifestations together with the lack of knowledge of it, being in the absence of this lesion, an easily diagnosable pathology, do not require excessive complementary tests, and with an excellent prognosis after the appropriate early treatment.

Agreement between Framingham-DORICA and SCORE scales in estimation of cardiovascular risk in the patients suffering from metabolic syndrome in Granada (Spain).

BACKGROUND AND OBJECTIVE: The aim of the present study was to compare the risk stratification obtained with the Framingham function, recommended by the National Cholesterol Education Program (ATP-III), and the risk charts of the Systematic Coronary Risk Evaluation (SCORE) program, in a cohort of subjects between 20 and 75 years (mean 59 years, 70% females) with metabolic syndrome. SUBJECTS AND METHOD: Participants were classified as low, moderate, or high risk by ATP-III and by SCORE of risk at 10 years, respectively. RESULTS: 8.3% of males and 7.4% of women from our study were classified as high risk in 10 years time by Framingham-DORICA. Regarding SCORE program 50% men and 29.6% of women were considered to have high coronary risk. CONCLUSIONS: Risk estimation with SCORE and Framingham function shows significant gender and quantitative differences. There is no concordance between Framingham and SCORE function to estimate cardiovascular risk on subjects included on the high-risk group.

Implante hormonal subcutáneo: experiencia en una unidad clínica / Subdermal hormonal implant: an experience in a clinical unit

En España el número de Interrupciones Voluntarias de Embarazo (IVE) es elevado, así como la tasa de embarazos no deseados. en los últimos años ha variado notablemente el abanico de métodos anticonceptivos disponibles en nuestro país. Algunos de ellos, ya disponibles en otros países, se han introducido aquí, como es el caso del implante hormonal subcutáneo (IHS), considerado en la actualidad el anticonceptivo más eficaz, presentando además un excelente balance riesgo/beneficio. En el presente trabajo se analiza el perfil de las usuarias, así como los efectos adversos, grado de satisfacción e indicación del implante hormonal subcutáneo (IHS)

In Spain, the number of Volutary Interruptions of Pregnancy is high, as well as the rate of unintended pregnancies. Recently, the range of contraceptive methods available for Spaniards has widened considerably. Some of them, which were already available in other countries, have been introduced in Spain, such as the Subcutaneous Hormoonal Implant, regarded as the most effective contraceptive nowadays. Furthermore, it shows a great risk/benefit balance. The aim of this paper is the analysis of the users profile, the adverse effects, the degree of satisfaction and the methos used for women to carry the subdermal hormonal implant

Genetic diversity and relationships among Venezuelan equine encephalitis virus field isolates from Colombia and Venezuela.

During field studies of enzootic Venezuelan equine encephalitis (VEE) viruses associated with epizootic emergence, a large number of virus isolates were made in sylvatic foci of Venezuela and Colombia. To rapidly characterize these isolates, antigenic subtypes were determined by means of immunofluorescence and by single-strand conformational polymorphism (SSCP) analysis by use of an 856-bp fragment from the P62 gene, which we used to distinguish genetic variants. Representative isolates were sequenced to assess the sensitivity of SSCP to detect genetic differences. The SSCP analysis distinguished isolates differing by as little as 1 nucleotide; overall, differences of > or = 1 nucleotide were recognized 89% of the time, and the sensitivity to distinguish strains that differed by only 1 or 4 nucleotides was 17 and 57%, respectively. Phylogenetic analyses of representative sequences showed that all recent isolates from the Catatumbo region of western Venezuela and the middle Magdalena Valley of Colombia were closely related to epizootic subtype IAB and IC strains; strains from Yaracuy and Miranda States were more distantly related. Cocirculation of the same virus genotype in both Colombian and Venezuelan foci indicated that these viruses are readily transported between enzootic regions separated by > 300 km. The SSCP analysis appears to be a simple, fast, and relatively efficient method of screening VEE virus isolates to identify meaningful genetic variants.