RESUMO
ABSTRACT Objective: This review aimed to analyze interventions raised within primary and tertiary prevention concerning the disease's incidence, progression, and recurrence of Prostate Cancer (PCa). Priority was given to the multidisciplinary approach of PCa patients with an emphasis on modifiable risk factors. Materials and Methods: We conducted a comprehensive literature review in the following databases: Embase, Central, and Medline. We included the most recent evidence assessing cohort studies, case-control studies, clinical trials, and systematic reviews published in the last five years. We only included studies in adults and in vitro or cell culture studies. The review was limited to English and Spanish articles. Results: Preventive interventions at all levels are the cornerstone of adherence to disease treatment and progression avoidance. The relationship in terms of healthy lifestyles is related to greater survival. The risk of developing cancer is associated to different eating habits, determined by geographic variations, possibly related to different genetic susceptibilities. Discussion: PCa is the second most common cancer in men, representing a leading cause of death among men in Latin America. Prevention strategies and healthy lifestyles are associated with higher survival rates in PCa patients. Also, screening for anxiety and the presence of symptoms related to mood disorders is essential in the patient's follow-up concerning their perception of the condition.
Assuntos
Humanos , Masculino , Adulto , Neoplasias da Próstata , Programas de Rastreamento , Incidência , Fatores de Risco , Estilo de VidaRESUMO
OBJECTIVE: This review aimed to analyze interventions raised within primary and tertiary prevention concerning the disease's incidence, progression, and recurrence of Prostate Cancer (PCa). Priority was given to the multidisciplinary approach of PCa patients with an emphasis on modifiable risk factors. MATERIALS AND METHODS: We conducted a comprehensive literature review in the following databases: Embase, Central, and Medline. We included the most recent evidence assessing cohort studies, case-control studies, clinical trials, and systematic reviews published in the last five years. We only included studies in adults and in vitro or cell culture studies. The review was limited to English and Spanish articles. RESULTS: Preventive interventions at all levels are the cornerstone of adherence to disease treatment and progression avoidance. The relationship in terms of healthy lifestyles is related to greater survival. The risk of developing cancer is associated to different eating habits, determined by geographic variations, possibly related to different genetic susceptibilities. DISCUSSION: PCa is the second most common cancer in men, representing a leading cause of death among men in Latin America. Prevention strategies and healthy lifestyles are associated with higher survival rates in PCa patients. Also, screening for anxiety and the presence of symptoms related to mood disorders is essential in the patient's follow-up concerning their perception of the condition.
Assuntos
Neoplasias da Próstata , Adulto , Humanos , Incidência , Estilo de Vida , Masculino , Programas de Rastreamento , Fatores de RiscoRESUMO
The aim of this scoping review was to identify knowledge gaps and to describe the current state of the research on the association between TMPRSS2 and the essential beta coronaviruses (Beta-CoVs) infection and the molecular mechanisms for this association. We searched MEDLINE (OVID), EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL). We included 13 studies. Evidence shows an essential role of TMPRSS2 in Spike protein activation, entry, and spread into host cells. Co-expression of TMPRSS2 with cell surface receptors (ACE2 or DPP4) increased virus entry. This serine protease is involved in the formation of large syncytia between infected cells. TMPRSS2 cleaved the Spike protein of SARS-CoV, SARS-CoV-2, and MERS-CoV, and increased virus propagation. Accumulating evidence suggests that TMPRSS2 is an essential protease for virus replication. We highlighted its critical molecular role in membrane fusion and the impact in viral mRNA replication, then promoting/driving pathogenesis and resistance.
Assuntos
COVID-19 , Infecções por Coronavirus/genética , Serina Endopeptidases , COVID-19/genética , Linhagem Celular , Humanos , Coronavírus da Síndrome Respiratória do Oriente Médio , Coronavírus Relacionado à Síndrome Respiratória Aguda Grave , SARS-CoV-2 , Serina Endopeptidases/genética , Glicoproteína da Espícula de Coronavírus , Internalização do VírusRESUMO
A 27 años del nacimiento del Hospital Garrahan, hemos sentido la necesidad de compartir con el equipo de salud las estrategias de atención del niño y su familia utilizadas en nuestro Hospital, colaborar con su actualización permanente y poner énfasis en el trabajo interdisciplinario. En este tomo desarrollamos el tema del niño con cardiopatía congénita. Se trata de la malformación congénita grave más frecuente, que se presenta en aproximadamente 5 a 8 cada mil nacidos vivos. En Argentina, nacen alrededor de 700.000 niños cada año, es decir alrededor de 4.500 con esta patología. La supervivencia actual con calidad de vida futura normal es alta para la mayoría de estos niños. A esto contribuyen las mejoras en el diagnóstico prenatal y neonatal temprano, el traslado seguro, la estabilización preoperatoria y el tratamiento por equipos cardiovasculares interdisciplinarios. El rol del pediatra es fundamental en el diagnóstico y seguimiento de estos pacientes. En este volumen, el pediatra encontrará aspectos epidemiológicos y patogénicos de algunas de las enfermedades más prevalentes, así como claves para el diagnóstico oportuno, con énfasis en la semiología y los estudios complementarios accesibles, indicaciones de derivación, prevención de riesgos y asesoramiento general para pacientes y padres.
Assuntos
Humanos , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Coartação Aórtica , Estenose da Valva Aórtica/congênito , Argentina , Diagnóstico Diferencial , Seguimentos , Cardiopatias Congênitas , Comunicação Interventricular , Ventrículos do Coração/anormalidades , Transtornos do Neurodesenvolvimento , Complicações Pós-Operatórias , Diagnóstico Pré-Natal , Tetralogia de Fallot , Cirurgia Torácica , Transição para Assistência do Adulto , Transposição dos Grandes VasosRESUMO
El diagnóstico es Rabdomiomas cardiacos/ Esclerosis tuberosa.
Assuntos
Humanos , Masculino , Recém-Nascido , Esclerose Tuberosa/diagnóstico , Esclerose Tuberosa , Esclerose Tuberosa/terapia , Recém-Nascido , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas , Neoplasias Cardíacas , Rabdomioma/diagnóstico , Rabdomioma , Rabdomioma/terapia , ArgentinaRESUMO
El diagnóstico es Rabdomiomas cardiacos/ Esclerosis tuberosa
