[Progressive radiation-induced rectal injury: is there an opportunity to get out of a vicious circle? A clinical case].

Radiation therapy is one of the main treatment option for prostate cancer used either independently or as a component of combined and complex treatment of the disease. Modern achievements make it possible to deliver doses of radiation that match the exact dimensions of the tumor for greater efficacy, with minimal exposure of the surrounding tissues, however, does not eliminate them. In most patients, clinical manifestations of chronic radiation proctitis occur during the first 2 years after radiation therapy. The article summarizes the current knowledge about pathophysiology, clinical manifestations, diagnostics and treatment options for this condition. In this paper, we present a case of complicated of chronic radiation proctitis.

[TROPHOLOGY ASPECTS OF NOOCPHEROGENESIS. On the 90th anniversary of A M Ugolev].

This paper presents an analytical review of A. Ugolev's scientific heritage (the theory of adequate nutrition, all-purpose functional blocks, the unity of natural and artificial technologies, the discovery of membrane digestion, new doctrine--trophology) to explain trophological aspects of noospherogenesis. The authors have presented their specific views for the development of these ideas; the theory of therapeutic infections, the holistic theory of nutrition, the endoecological deficiency syndrome, the activation of all-purpose functional blocks, evasion receptors, new principles of treatment with the effects on microbiota, combining the essence of the diseases and their treatment.

[Endocrine cells of rectal epithelium in health, in nonspecific ulcerative colitis and irritable colon syndrome in the treatment with prednisolone and salofalk and in the absence of treatment]. / Endokrinnye kletki épiteliia priamoi kishki v norme, pri nespetsificheskom iazvennom kolite i sindrome razdrazhennoi kishki bez lecheniia i pri lechenii prednizolonom i salofal'kom.

The arrangement and ultrastructure of rectal intraepithelial endocrine cells in health, in nonspecific ulcerative colitis (NSUC) and in irritable colon syndrome (ICS) were studied with light and electron microscopy. An increase of the amount of these cells was registered at the initial stages of inflammation, whereas chronic and destructive states were accompanied by the cells decrease. A decrease of endocrine cells number in (NSUC) was pronounced more than in ICS. Compared to prednisolone, the treatment with salofalk produced a more positive effect on endocrine cells reproduction within the rectal lining. The endocrine cells ultrastructural changes found by the authors in ulcerative colitis and irritable colon showed similarity to those in other colon diseases.