RESUMO
Infarctions of the long bones in sickle cell anemia and some of its variant hemoglobinopathies are well known. Photopenia representing areas of acute infarctions of the ilia in two young children are presented as unusual presentations of bone ischemia.
Assuntos
Hemoglobinopatias/complicações , Ílio/irrigação sanguínea , Infarto/etiologia , Pré-Escolar , Humanos , Ílio/diagnóstico por imagem , Lactente , Infarto/diagnóstico por imagem , Masculino , CintilografiaRESUMO
We report a case of neonatal alloimmune thrombocytopenia and intracranial hemorrhage in an infant whose mother received immunizations of paternal mononuclear cells. This therapy is designed to prevent unexplained first trimester miscarriages. No previous cases of platelet autoimmunization associated with maternal immunization with paternal mononuclear cells has been reported. Treatment with antenatal maternal infusions of intravenous gamma globulin (IVGG) did not prevent fetal thrombocytopenia, but IVGG may become the treatment of choice for postnatal, antibody-mediated thrombocytopenia of the newborn.
Assuntos
Imunização/efeitos adversos , Imunoglobulina G/uso terapêutico , Imunoglobulinas Intravenosas/uso terapêutico , Monócitos , Efeitos Tardios da Exposição Pré-Natal , Trombocitopenia/terapia , Aborto Habitual/terapia , Adulto , Hemorragia Cerebral/imunologia , Hemorragia Cerebral/terapia , Feminino , Humanos , Imunização/métodos , Recém-Nascido , Troca Materno-Fetal , Gravidez , Trombocitopenia/imunologiaRESUMO
Cytogenetic studies of a rhabdomyosarcoma of mixed embryonal and alveolar histology in an 11-month-old male revealed a single structural abnormality, t(1;13)(p36;q14). This abnormality may define a subset of patients with a variant of the t(2;13)(q35;q14) translocation frequently seen in alveolar rhabdomyosarcoma.