Insulinoma Associated with MEN1 Syndrome: A Case of Persistent Hypoglycemia in School-aged Child.

Insulinoma is a rare cause of non-ketotic hypoglycemia both in adults and in children. Pediatric patients account for approximately 5% of all cases, mostly due to isolated benign lesions, but it can also be part of a multiple endocrine neoplasia type 1 syndrome (MEN1). We report the case of a patient with multiple hospitalizations related to hypoglycemia and neuroglycopenia symptoms, with multiple studies demonstrating the presence of an insulinoma as part of the spectrum of MEN1 syndrome. The primary significance of our report is to underscore that insulinoma can present as the initial manifestation of MEN1 syndrome in 10% of pediatric patients. Furthermore, we describe a likely pathogenic variant in the MEN1 gene not previously reported in the literature. Our report highlights the importance of the convergence of clinical, biochemical and molecular investigations in establishing a precise diagnosis, prognosis, and appropriate follow-up for pediatric patients with hypoglycemia.

Alopecia universal como presentación inicial de un síndrome poliglandular autoinmune reporte de caso / Alopecia Universal as an initial presentation of an autoimmune Polyglandular Syndrome case report

Introducción: La alopecia universalis es la pérdida de pelo en todo el cuerpo por destrucción del folículo capilar. En la etiología se describen factores 1. Genéticos como alteración del cro-mosoma 18, haplotipos HLA DQ3, DQ7, DR4 y DR11. 2. Autoinmunes mediados por linfo-citos T CD4+. 3. Asociación con enfermedad poliglandular autoinmune. 4. Factores externos desencadenantes (psicológicos, estrés, etc.) (1).