The I.3.2 developmental mutant has a single nucleotide deletion in the gene centromere identifier.

The mutation I.3.2 was previously identified in a FLP/FRT screen of chromosome 2R for conditional growth regulators. Here we report the phenotypic characterization and genetic mapping of I.3.2 by undergraduate students participating in Fly-CURE, a pedagogical program that teaches the science of genetics through a classroom research experience. We find that creation of I.3.2 cell clones in the developing eye-antennal imaginal disc causes a headless adult phenotype, suggestive of both autonomous and non-autonomous effects on cell growth or viability. We also identify the I.3.2 mutation as a loss-of-function allele of the gene centromere identifier ( cid ), which encodes centromere-specific histone H3 variant critical for chromosomal segregation.

Diarrea como expresión clínica de gastrinoma: informe de un caso / Diarrhea as a clinical expression of Zollinger Ellison

Se presenta un caso de síndrome de Zollinger Ellison, cuya manifestación principal fue diarrea crónica, sin datos de enfermedad ácido péptica. El objetivo del presente trabajo es informar una expresión clínica poco usual en una paciente con gastrinoma; así como los métodos empleados (determinación de gastrina, estimulación secretina y angiotomografía) para la cofirmación del diagnóstico y su manejo terapéutico quirúrgico con resección del tumor.