1.
Chem Commun (Camb)
; 60(26): 3571-3574, 2024 Mar 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38469678
RESUMO
Herein, a novel Pd-catalyzed denitrogenation/vinylation of benzotriazinones using vinylene carbonate as the vinylation reagent is reported. This transformation demonstrates an unprecedented skeletal editing approach, effectively converting NîN to CîC fragments in situ and synthesizing a collection of isoquinolinones with broad-spectrum functional group tolerance. Moreover, the quite concise reaction system and late-stage modification of bioactive molecules comprehensively underscore the practical potential of this protocol.