Sea squirt-inspired bio-derived tissue sealants.

Sea squirts' or tunicates' bodies are composed of cellulose nanofibers and gallol- functionalized proteins. These sea creatures are known to heal their injuries under seawater by forming crosslinks between gallols and functional groups from other proteins in their bodies. Inspired by their wound healing mechanism, herein, we have developed a tissue sealant using zein (a plant-based protein) and tannic acid (gallol-containing polyphenol). Except for fibrin- based sealants, most commercial surgical adhesives, and sealants available today are derived from petroleum products that compromise their biodegradability. They often have complicated and multi-step synthesis processes that ultimately affect their affordability. To overcome this challenge, we ensured that these sea squirt-inspired tissue sealants are bio-based, easily synthesized, and low-cost. The sealants were studied on their own and with a food-grade enzyme transglutaminase. The adhesion performances of the sealants were found to be higher than physiological pressures in seven out of nine different tissue substrates studied here. Their performance was also better than or on par with the FDA-approved fibrin sealant Tisseel. Ex vivo models demonstrate instant sealing of leaking wounds in less than a minute. The sealants were not only cytocompatible but also showed complete wound healing on par with sutures and Tisseel when applied in vivo on skin incisions in rats. Overall, these sea squirt-inspired bio-based sealants show great potential to replace currently available wound closure methods.

Graphene templated growth of copper sulphide 'flowers' can suppress electromagnetic interference.

With increasing usage of electronic gadgets in various fields, the problem of electromagnetic interference (EMI) has become eminent. To suppress this interference, lightweight materials that are non-corrosive in nature and easy to fabricate, design, integrate and process are in great demand. In the present study, we have grown copper sulphide 'flowers' on graphene oxide by a facile one pot hydrothermal technique. The growth time of the "flower-like" structure was optimised based on structural (XRD) and morphological analysis (SEM). Then, the as-prepared structures were dispersed in a PVDF matrix using melt blending. The bulk AC electrical conductivity and EMI shielding ability of the prepared composite were assessed, and it was observed that the nanocomposites exhibited an EMI shielding effectiveness up to -25 dB manifesting in 86% absorption of the incoming EM waves at a thickness of only 1 mm. Moreover, it was also observed that addition of hybrid nanoparticles has a better effect on the electromagnetic (EM) shielding performance compared to when the nanoparticles are added separately in terms of both total shielding effectiveness as well as absorption performance. A minimum skin depth of 0.38 mm was observed in the case of the hybrid nanostructure.

Ultrafast Self-Healable Interfaces in Polyurethane Nanocomposites Designed Using Diels-Alder "Click" as an Efficient Microwave Absorber.

In the recent times, multifunctional materials have attracted immense interest. Self-healing polymers are in great demand in almost every coating application. With an increase in electromagnetic (EM) pollution, curbing the same has become an urgent necessity. Lightweight coatings and conducting polymeric materials are being highly researched upon in this regard, and combining these properties with self-healing systems would open new avenues in EM interference (EMI) shielding (specifically in the microwave frequency domain) applications. In the current study, a novel approach toward the development of microwave shielding materials capable of self-healing through microwave heating has been attempted. A covalently cross-linked material was developed using Diels-Alder (DA) chemistry, which shows self-healing properties when stimulated by heating. Herein, reduced graphene oxide grafted with magnetite nanoparticles (rGO/Fe3O4) was covalently cross-linked to thermoplastic polyurethane using DA chemistry. The addition of multiwalled carbon nanotubes into these nanocomposites led to exceptional EM wave shielding and self-healing properties through a synergistic effect. The synergism led to exceptional EMI shielding of -36 dB, primarily through absorption in the microwave region of the EM spectrum. When used in the form of thin coatings of about 1 mm in thickness, the shielding value reached -28 dB, manifesting in more than 99% attenuation of EM waves through absorption. The material was also found to be capable of healing scratches or cuts through microwave irradiation.

Phase specific dispersion of functional nanoparticles in soft nanocomposites resulting in enhanced electromagnetic screening ability dominated by absorption.

The effect of phase specific localisation of MWNTs (multiwalled carbon nanotubes) and magnetic FeNi (iron-nickel) alloy particles on bulk electrical conductivity and electromagnetic (EM) wave attenuation was investigated in biphasic co-continuous blends of PVDF/SMA (polyvinylidene fluoride/styrene maleic anhydride). It is envisaged that packing different functional nanoparticles in a given phase of a co-continuous blend can impede the charge transport phenomenon and the overall dispersion state. Therefore, phase specific localisation can facilitate the tuning of the functional properties in biphasic blends. This strategy was adopted here wherein conducting MWNTs and magnetic FeNi particles were surface tailored to position them in different phases during processing. As the functional particles prefer the PVDF phase by virtue of thermodynamics, by harnessing amine functional moieties on the surface, their localisation can be tuned to position them in the SMA phase (due to amine-anhydride coupling). This was achieved by sequential mixing during processing. For the best combination, SET was observed to be -23 dB when MWNTs were localised in the SMA phase and magnetic particles in the PVDF phase of the blend with an impressive 92% absorption of the incident EM radiation.