Facial Recognition Task for the Classification of Mild Cognitive Impairment with Ensemble Sparse Classifier.

Conventional methods for detecting mild cognitive impairment (MCI) require cognitive exams and follow-up neuroimaging, which can be time-consuming and expensive. A great need exists for objective and cost-effective biomarkers for the early detection of MCI. This study uses a sequential imaging oddball paradigm to determine if familiar, unfamiliar, or inverted faces are effective visual stimuli for the early detection of MCI. Unlike the traditional approach where the amplitude and latency of certain deflection points of event-related potentials (ERPs) are selected as electrophysiological biomarkers (or features) of MCI, we used the entire ERPs as potential biomarkers and relied on an advanced machine-learning technique, i.e. an ensemble of sparse classifier (ESC), to choose the set of features to best discriminate MCI from healthy controls. Five MCI subjects and eight age-matched controls were given the MoCA exam before EEG recordings in a sensory-deprived room. Traditional time-domain comparisons of averaged ERPs between the two groups did not yield any statistical significance. However, ESC was able to discriminate MCI from controls with 95% classification accuracy based on the averaged ERPs elicited by familiar faces. By adopting advanced machine-learning techniques such as ESC, it may be possible to accurately diagnose MCI based on the ERPs that are specifically elicited by familiar faces.

Non-Invasive, Cost-Effective, Early Diagnosis of Mild Cognitive Impairment in an Outpatient Setting: Pilot Study.

Mild cognitive impairment (MCI) and Alzheimer's Disease (AD) affect millions worldwide, yet no curative treatments for these neuro-degenerative disorders have been developed to date. The current study aims to propose a noninvasive, cost-effective, early diagnostic protocol for individuals suffering with MCI in an outpatient setting. Elderly participants (n=11) were screened for MCI utilizing the Montreal Cognitive Assessment (MoCA) questionnaire preceding a visual stimuli task. Participants were presented with facial stimuli to elicit event related potentials (ERP) while their cortical activity was recorded utilizing electroencephalogram (EEG). Combining regional neurophysiological biomarkers into a multidimensional feature space allowed for differentiation between healthy and MCI participants based on their respective MoCA scores. This study illustrates the feasibility of recording reliable EEG in an outpatient setting while presenting a novel method for diagnosing MCI in elderly (age >60) populations.