Tenosinovitis tuberculosa de tendones flexores de la mano. Caso clínico / Tuberculous tenosynovitis of flexor tendons of the hand. Case report

La tenosinovitis tuberculosa es una forma infrecuente de presentación de la tuberculosis extrapulmonar, de comportamiento crónico y usualmente confundida con otras enfermedades como la artritis reumatoide o el síndrome del túnel del carpo, entre otras. Es importante tener en cuenta el diagnóstico de tuberculosis en las tenosinovitis crónicas y no se debe descartar aunque no haya presencia de cuerpos de arroz. Describimos el proceso diagnóstico en una paciente que consultó por síntomas crónicos de dolor, edema y limitación funcional en la cara palmar de la mano derecha, sin cambios patológicos en la radiografía, pero con signos ecografícos de tenosinovitis. Describimos la evolucion clínica tras recibir tratamiento antituberculoso y realizar tenosinovectomia de los tendones flexores del 1°, 3° y 5° dedos. (AU)

Tuberculous tenosynovitis is an infrequent form of presentation of extrapulmonary tuberculosis, of chronic behavior and usually confused with other diseases such as rheumatoid arthritis or carpal tunnel syndrome, among others. It is important to take into account the diagnosis of tuberculosis in chronic tenosynovitis and it should not be ruled out in the absence of rice bodies. We describe the diagnostic process in a patient who consulted for chronic symptoms of pain, edema and functional limitation in the palmar aspect of the right hand without pathological changes on the radiograph, but with ultrasound signs of tenosynovitis. We describe the clinical evolution after receiving anti-tuberculosis treatment and performing tenosynovectomy of flexor tendons of the 1st, 3rd and 5th fingers. (AU)

Oct-6 transcriptional factor a possible biomarker for leprosy diagnosis.

Leprosy is an infectious disease caused by Mycobacterium leprae that affects the skin and nerves. The nerve damage in leprosy may be related to alterations in transcriptional factors, such as Krox-20, Oct-6, Sox-10. Thirty skin biopsies in leprosy patients and 15 non-leprosy skin biopsies were evaluated using RT-qPCR to assess Krox-20, Oct-6, and Sox-10 and these data was related with S-100 immunohistochemistry. Changes in gene expression were observed in the skin and dermal nerves of leprosy patients in Oct-6 and Sox-10. When comparing Oct-6 with S-100 IHC as diagnostic tests for leprosy, Oct-6 showed a sensitivity of 73.3%, and specificity of 100%, while S-100 IHC showed a sensitivity of 96.6% and specificity of 100%. Our data suggest Oct-6 could be an auxiliary biomarker specific to detecting changes in dermal nerves in leprosy and thus useful to health workers and pathologists with no expertise to observe nerve injuries in leprosy.