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OBJECTIVES: We aimed to compare preterm, neurodevelopmentally disordered and healthy full-term children. METHODS: We enrolled 47 children who were born preterm, 40 neurodevelopmentally disordered children, and 80 healthy children as control participants, in order to assess the cognitive functioning and the risk of behavioral problems at the age of 5. Children were assessed using the Korean Wechsler Preschool and Primary Scale of Intelligence-4th edition (K-WPPSI-IV), the Child Behavior Checklist (CBCL), and the Temperament and Character Inventory (TCI). RESULTS: The mean K-WPPSI-IV score of the preterm group was 87.19±17.36, which was significantly higher than that of the neurodevelopmental disorder group (69.98±28.63; p < 0.001) but lower than that of the control group (107.74±14.21; p < 0.001). The cumulative CBCL scores of the preterm children were not significantly different from those of the control group. Additionally, the TCI scores for reward dependence of the preterm children were higher than those of the control group. CONCLUSION: The cognitive performance of preterm infants was lower than that of healthy full-term infants at the age of 5, and there was an association between slower growth and decreased cognitive ability.
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Criança , Humanos , Lactente , Recém-Nascido , Lista de Checagem , Comportamento Infantil , Cognição , Recém-Nascido Prematuro , Transtornos do Neurodesenvolvimento , Comportamento Problema , Recompensa , TemperamentoRESUMO
PRF001 is a fragmented DNA polymer extracted from the testes of salmon. The purpose of this study was to assess the anti-inflammatory effect of PRF001 in vitro as well as the protective effect of PRF001 intake against arthritis in a rat model. In vitro, cell survival and inflammatory markers after H₂O₂ treatment to induce cell damage were investigated in CHON-001 cells treated with different concentrations of PRF001. In vivo, osteoarthritis was induced by intra-articular injection of monosodium iodoacetate (MIA) into the knee joints of rats. After consumption of PRF001 (10, 50, or 100 mg/kg) for 4 weeks, inflammatory mediators and cytokines in articular cartilage were investigated. In vitro, the levels of inflammatory markers, IL-1β, TNF-α, COX-2, iNOS, and PGE2, were significantly suppressed by PRF001 treatment. In vivo, the inflammatory mediators and cytokines, IL-1β, p-Erk1/2, NF-κB, TNF-α, COX-2, and PGE2, as well as MMP3 and MMP7, which have catabolic activity in chondrocytes, were decreased in the MIA-induced osteoarthritic rats following intake of PRF001. Histological analysis revealed that PRF001 had a protective effect on the articular cartilage. Altogether, these results demonstrated that the anti-inflammatory property of PRF001 contributes to its protective effects in osteoarthritis through deregulating IL-1β, TNF-α, and subsequent signals, such as p-Erk1/2, NF-κB, COX-2, PGE2, and MMPs.
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Animais , Ratos , Artrite , Cartilagem Articular , Sobrevivência Celular , Condrócitos , Citocinas , Dinoprostona , DNA , Técnicas In Vitro , Inflamação , Injeções Intra-Articulares , Articulação do Joelho , Metaloproteinases da Matriz , Modelos Animais , Osteoartrite , Polímeros , Salmão , TestículoRESUMO
The authors note that on pages 167 (Fig. 2A), 168 (Fig. 3A), and 169 (Fig. 4A), the figure label “RPF-001” should instead appear as “PRF-001.”
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The use of service robots is gaining increasing interest in stroke rehabilitation research. In autonomous robot therapy sessions, it is important to monitor the qualitative motor performance of the patient and to evaluate if therapeutically desirable movements are reinforced as per the therapist's instructions. Research on computational means to address this issue has received little attention, despite the acknowledged importance thereof. This paper poses the question of whether the subjective evaluation of the therapist on the qualitative motor performance of the individual patient can be modelled. In an attempt to answer this question, we frame it as a supervised machine learning problem and investigate if kinematic sensor readings to the subjective evaluation of the therapist can be correlated. We further examine if the personalized classifier trained with the data of the individual patient should be favored over the general classifier. Our preliminary results suggest that, given kinematic observation, trained classifiers may be able to imitate the evaluation of the therapist for the movement quality of the post-stroke patient. In our experiments, the general classifier outperformed the personalized classifiers, however, further investigation is necessary to generalize this finding.
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Movimento , Fenômenos Biomecânicos , Terapia por Exercício , Humanos , Acidente Vascular Cerebral , Reabilitação do Acidente Vascular CerebralRESUMO
OBJECTIVES: The current study examined the effect of birth weight on the relationship between age and IQ of children, who were born preterm with very low birth weight (VLBW) or extremely low birth weight (ELBW). METHODS: The study subjects were 82 children, aged between 3–5 years, who visited the neonatal intensive care unit of a university hospital located in Seoul. The children had been born prematurely with VLBW or ELBW. Their IQ was tested using the performed Korean-Wechsler Preschool and Primary Scale of Intelligence fourth edition. RESULTS: A hierarchical regression analysis showed a significant interaction effect of birth weight and age on Full Scale IQ (FSIQ); the effect of age on FSIQ differed according to birth weight. For the group with VLBW, FSIQ was more likely to be higher with increasing age. Conversely, for the group with ELBW, FSIQ remained low regardless of the age level. In addition, birth weight and age had a significant interaction effect on the Visual Spatial Index. Birth weight had a significant main effect on Verbal Comprehension Index. CONCLUSION: This research suggested the possibility of predicting the cognitive developmental of premature children, by highlighting the fact that prematurely born children, with VLBW/ELBW, have different cognitive developmental trajectories.
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Criança , Humanos , Recém-Nascido , Peso ao Nascer , Compreensão , Recém-Nascido de Baixo Peso , Recém-Nascido de muito Baixo Peso , Inteligência , Terapia Intensiva Neonatal , Nascimento Prematuro , SeulRESUMO
Neurodevelopmental disorders are characterized by impaired development that causes adjustment problems. The spectrum of developmental impairment varies and includes intellectual disabilities, communication and social interaction challenges, and attention and executive function deficits. The neurodevelopmental disorders include intellectual disability, communication disorder, autism spectrum disorder, attention-deficit/hyperactivity disorder, neurodevelopmental motor disorders, and specific learning disorder. The differential diagnosis of neurodevelopmental disorders is important, comprehensive psychological assessmentsare required for individuals who may have a neurodevelopmental disorder. This paper focuses on intellectual, neuropsychological, adaptive behavior, and autism diagnostic assessments and psychiatric comorbidities. These assessments accurately screen for neurodevelopmental disorders and aid in differential diagnosis. The goals of psychological assessment include facilitating therapeutic planning, and suggesting prognosis. Further research is required to clarify each aspect of neurodevelopmental disorders and optimize psychological assessment tools accordingly.
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Criança , Adaptação Psicológica , Transtorno Autístico , Transtornos da Comunicação , Comorbidade , Diagnóstico Diferencial , Função Executiva , Deficiência Intelectual , Inteligência , Relações Interpessoais , Deficiências da Aprendizagem , Prognóstico , Testes Psicológicos , Avaliação de Sintomas , Transtorno do Espectro AutistaRESUMO
PURPOSE: Atopic dermatitis (AD) is a genetically determined, chronic relapsing skin disease. The pathogenesis of AD is complex and the course is unpredictable. Atopy is an important risk factor for the development of AD. Cysteinyl leukotrienes (Cys-LTs) were implicated in the pathophysiology of allergic diseases, and are being targeted for their diagnosis and treatments. Early detection of tissue inflammation of target organ is important to enable early prevention and management of allergic diseases. The aim of our study is to evaluate the differences in urinary leukotrienes E4 (LTE4) levels, according to AD symptom score and aeroallergen sensitization in children with AD by using noninvasive techniques. METHODS: We recruited 46 children with AD, using predetermined criteria. Clinical features of AD were evaluated by a physician, using scoring atopic dermatitis (SCORAD) index. Aeroallergen sensitization was measured by using a skin prick test and UniCap. Urine samples were also collected on day of the 1st and 2nd visits, and were analyzed for LTE4 with an enzyme-linked immunoassay kit. RESULTS: SCORAD indeces of children with AD were correlated with urinary LTE4 levels. Total immunoglobulin E (IgE) and eosinophil counts also had significant correlation with urinary LTE4 levels. Especially, aeroallergen sensitization of atopic AD significantly correlated with urinary LTE4 of these patients. CONCLUSION: Urinary LTE4 levels significantly correlated with serum total IgE and number of sensitized aeroallergen in children with AD. Clinical features of AD evaluated with SCORAD index related with urinary LTE4 level. Urinary LTE4 might be a valuable, noninvasive marker for different pathogenesis of AD.
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Criança , Humanos , Dermatite Atópica , Eosinófilos , Imunoensaio , Imunoglobulina E , Imunoglobulinas , Inflamação , Leucotrieno E4 , Leucotrienos , Fatores de Risco , Pele , DermatopatiasRESUMO
BACKGROUND AND PURPOSE: The vertebral artery (VA) is important for the development of the transverse foramen (TF). Most studies of these structures have focused on anatomical anomalies. Therefore, we investigated quantitatively the association between the relative sizes of the TF and VA. METHODS: We recruited a consecutive series of subjects who underwent CT angiography to estimate the relative sizes of the VA and TF in axial source images. Two neurologists independently reviewed the axial CT images of 208 patients who had no history of transient ischemic attack or stroke. Averaged areas of the VA and TF were defined by the sum of the areas at each level from C3 to C6, divided by 4. Correlation analyses were adjusted for age, sex, and vascular risk factors. RESULTS: The mean age of the subjects was 53 years. The interobserver and intraobserver reliabilities of TF size were good. There was a linear relationship between the sizes of the VA and TF on each side (right side: r2=0.58, p<0.001; left side: r2=0.62, p<0.001). The area of the VA was significantly associated with that of the TF after adjusting for vascular risk factors. CONCLUSIONS: The size of the VA is strongly and linearly correlated with the size of the TF. These findings suggest that measurement of the TF and VA with CT angiography is a reliable method for evaluating VA diseases, and may provide new insight into the differentiation between VA hypoplasia and atherosclerosis of the VA.
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Humanos , Angiografia , Aterosclerose , Ataque Isquêmico Transitório , Acidente Vascular Cerebral , Artéria VertebralRESUMO
BACKGROUND AND PURPOSE: It was recently reported that the prevalence of poststroke memory dysfunction might be higher than previously thought. Stroke may exist concomitantly with underlying Alzheimer's disease (AD), and so we determined whether post-stroke memory dysfunction indicates manifestation of underlying subclinical AD. METHODS: Of 1201 patients in a prospective cognitive assessment database, we enrolled subjects with poststroke amnestic vascular cognitive impairment-no dementia (aVCIND; n=48), poststroke nonamnestic vascular cognitive impairment-no dementia (naVCIND; n=50), and nonstroke amnestic mild cognitive impairment (aMCI; n=65). All subjects had cognitive deficits, but did not meet the criteria for dementia. A standardized neuropsychological test battery and magnetic resonance imaging were performed at least 90 days after the index stroke (mean, 473 days). Visual assessment of medial temporal atrophy (MTA) was used as a measure of underlying AD pathology. RESULTS: The MTA score was significantly lower in the naVCIND group (0.64+/-0.85, mean+/-SD) than in the aVCIND (1.10+/-1.08) and aMCI (1.45+/-1.13; p<0.01) groups. Multivariable ordinal logistic regression analysis revealed that compared with naVCIND, aVCIND [odds ratio (OR)=2.69; 95% confidence interval (CI)=1.21-5.99] and aMCI (OR=5.20; 95% CI=2.41-11.23) were significantly associated with increasing severity of MTA. CONCLUSIONS: Our findings show that compared with poststroke naVCIND, the odds of having more-severe MTA were increased for poststroke aVCIND and nonstroke aMCI.
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Humanos , Doença de Alzheimer , Atrofia , Demência , Glutamatos , Guanina , Modelos Logísticos , Imageamento por Ressonância Magnética , Memória , Disfunção Cognitiva , Testes Neuropsicológicos , Prevalência , Estudos Prospectivos , Pemetrexede , Acidente Vascular CerebralRESUMO
The dorsolateral medullary syndrome (Wallenberg's syndrome) is produced by infarction of a wedge of lateral medulla posterior to the inferior olivary nucleus, and is usually caused by vertebral artery occlusion. Ipsilateral axial lateropulsion as an initial symptom of vertebral artery occlusion is rare, and the responsible anatomical structure is still uncertain. Here we describe a patient presenting with ipsilateral axial lateropulsion as an initial symptom of vertebral artery occlusion.
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Humanos , Infarto , Síndrome Medular Lateral , Imageamento por Ressonância Magnética , Núcleo Olivar , Artéria VertebralRESUMO
The KIDSCREEN-52 quality-of-life (KIDSCREEN-52-HRQOL) is a relevant, worldwide tool used for assessing the health-related quality of life in children and adolescents. The purpose of this study was to define measurement properties of the Korean version of the KIDSCREEN-52 HRQOL. The original questionnaire was translated following international translation guidelines. Analysis regarding psychometric properties showed that the Cronbach-alpha ranged from 0.77 to 0.95. The correlation coefficient between the PedQL and KIDSCREEN-52 dimensions were high for the assessments of similar constructs. Therefore, the Korean version of the KIDSCREEN-52 was found to be suitable for use in Korean adolescents.
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Adolescente , Feminino , Humanos , Masculino , Nível de Saúde , Indicadores Básicos de Saúde , Inquéritos Epidemiológicos , Coreia (Geográfico) , Psicometria , Qualidade de Vida , Inquéritos e Questionários , Reprodutibilidade dos Testes , Projetos de PesquisaRESUMO
This study explores some basic issues behind adults' seeking and using patterns of alternative medicine as well as health food (health food/medicine). In order to do this, 791 adult participants in Seoul and Busan were interviewed face-to-face. The results of the survey showed that 1) interpersonal influence was the most influential factor in relation to the adoption of health food/medicine(46.9% of the participants reported on the influences), 2) keeping healthy was the main motivation for the usage of health food/medicine(34.5% of the participants), 3) mass media was the important information source for health food/medicine, 4) with regard to trustworthiness of information sources, experts were believed to be the most trustworthy while information from acquaintances were thought less, and finally, 5) pharmacies and health food stores were main suppliers of health food/medicine. This study suggests some marketing strategies for health food/medicine. For example, it can be suggested that interpersonal communication among other information channels should be focused and might be increased trust by using professionals.