[Therapeutic action of radioprotector indometofen].

The experiments on mice and dogs have shown the effectiveness of indomethofene administration after total acute radiation exposure. Introduction of indomethofene at doses of 15 and 30 mg/kg during time from 30 min to 3 days after irradiation resulted in reliable increase of mice survivability, 40-60% on average. Mice survival rate after single peroral introduction of indomethofene radioprotective doses was comparable with that resulting from referencing preparation estrofeme, which is estradiol oral dosage from (under the assumption that in contrast to indometafene estrofeme was introduced repeatedly every other day from 3 till 21 day after irradiation). Therapeutic action of indomethofene was confirmed in the experiments on dogs. After radiation exposure at a dose which caused the death of all dogs of control group, survival rate of experimental animals which received single oral dosage form of indomethofene at radioprotective dose in 1 and 3 days after irradiation was 40%. This study showed that indomethofene--long-acting radioprotector--is effective as therapeutic agent for acute radiation damage treatment.

[Influence of the indometafen radioprotector on the immune reactivity]. / Vliianie radioprotektora indometofena na immunologicheskuiu reaktivnost' organizma.

In the experiments on dogs and mice it was shown that indometophene could modify the immune status of the body. Specific and non-specific resistance of mice to E. coli infection increased after indometophene administration. At the same time higher titers of normal anti-salmonella antibodies in mice serum and a higher phagocytic activity of neutrophils in the peripheral blood in dogs were found. The influence of the preparation on the content of the complement and normal antibodies-hemagglutinins was less pronounced. It was suggested that the indometophene ability to bustle immune reactivity of the body played a certain role in the mechanism of its radioprotective effect.

[The role of beta-adrenoreceptors in the mechanism of the hemodynamic action and radiation-protective activity of the copolymer of 2-methyl-5-vinylpyridine with 2-methyl-5-vinylpyridinium-N-oxide]. / Izuchenie roli beta-adrenoretseptorov v mekhanizme gemodinamicheskogo deistviia i protivoluchevoi aktivnosti sopolimera 2-metil-5-vinilpiridina s 2-metil-5-vinilpiridinii-N-oksid.

In experiment on anesthetized dogs and cats in was shown that the new water-soluble copolymer initiated depressive reaction characteristic for beta-adrenomimetics. This effect was levelled with the help of non-selective adrenoblockator--propranololum. In experiment on dogs the preliminary treatment with propranololum decreased the therapeutic antiradiation efficiency of the copolymer from 68.4 to 8.3%.

[Experimental study of combined effect of actoprotectors and radioprotectors in radiation injury]. / Eksperimental'noe izuchenie vozmozhnosti sovmestnogo primeneniia ak toprotektorov i radioprotektorov pri luchevom porazhenii organizma.

Combined treatment of mice and dogs with actoprotector bimethyl and radioprotector indralin suppressed radioprotective action of the latter, the surveillance being decreased from 83.3 to 14.3% in dogs and from 70.3 to 5% in mice. At the same time vasodynamic action of indralin (increase of artherial pressure up to 30% from a reference level) did not change.

[Effect of co-polymer 2-methyl-5-vinylpyridine and 2-methyl-5- vinylpyridinium-n-oxide radiation induced myelodepression in mice]. / Vliianie sopolimera 2-metil-5-vinilpiridina s 2-metil-5-vinilpiridinii-n-oksidom na mielodepressiiu u myshei, vyzvannuiu oblucheniem.

On the model of cytopenia induced in mice by irradiation with a dose of 4.0 Gy it was shown that injection of examined copolymer (400 mg/kg) 3 h after irradiation exerts positive effect on haemopoietic system: the decrease of damage and acceleration of repair processes.

[Radioprotective activity and toxicity of copolymer 2-methyl-5-vinyl pyridine with 2-methyl-5-vinylpyridinium-n-oxide]. / Protivoluchevaia aktivnost' i toksichnost' sopolimera 2-metil-5-vinilpiridina s 2-metil-5-vinilpiridinii -n-oksidom.

In experiments in mice, hamsters and dogs therapeutic radioprotective efficiency and toxicity of new water-soluble copolymer were studied. It was found that at intramuscular injection of the copolymer to dogs in a dose of 5 mg/kg 24 h after irradiation with a dose of 3.30 Gy (LD85/45) it showed pronounced therapeutic effect (68.1%). In mice and hamsters, the effect was less pronounced: 42-21% after irradiation with a dose of 8.0 Gy. The copolymer is low toxic substance and according to the State standards of Russian Federation belongs to the fourth class (harmless).