[A possible biophysical mechanism of the solar activity effect on the central nervous system in man]. / Vozmozhnyi biofizicheskii mekhanizm vliianiia solnechnoi aktivnosti na tsentral'nuiu nervnuiu sistemu cheloveka.

A biophysical mechanism of interaction between the man and environment is proposed, which treats these components as two correlated oscillation contours with discrete resonance frequencies. The coincidence of biocurrent frequencies of the human brain with the resonance frequencies of the cavity formed by the Earth surface and the lower ionosphere boundary allows one to consider the influence of solar flares on the human organism in terms of variations of the cavity frequencies due to changes in the parameters of its upper wall.

[Elaboration of a quantitative method of evaluation of disease severity in patients with ventricular disorders of cardiac rhythm]. / Razrabotka kolichestvennogo metoda otsenki tiazhesti sostoianiia u bol'nykh s zheludochkovymi narusheniiami ritma serdtsa.

Mathematical approaches to the evaluation of the severity of the pathological process were used to develop an objective quantitative method to assess the severity of ventricular arrhythmias. The method is highly informative and reliable. It may be useful in the control of the efficacy of antiarrhythmic therapy and in the application of a differential approach to choice of therapy strategy for the patients.

[Etatsizin efficacy in patients with ventricular tachycardias. The results of intracardiac electrophysiological research]. / Effektivnost' étatsizina u bol'nykh s zheludochkovymi takhikardiiami. Rezul'taty vnutriserdechnogo élektrofiziologicheskogo issledovaniia.

As many as 30 patients with different pathologies of the cardiovascular system and paroxysms of ventricular tachycardias were examined. According to the ultrasonography data, an ejection fraction was not lower than 35% in all the patients. It has been shown by electrophysiological studies that intravenous injection of ethacizine in a dose of 0.6 +/- 0.1 mg/kg prevented induction of ventricular tachycardia in 66.7% of patients. In 16.7% of patients, the drug exerted an arrhythmogenic effect that showed up by a decrease of the cycle of tachycardia. Oral administration of ethacizine in the daily dose 100 or 150 mg prevented tachycardia induction by endocardial stimulation in 20.8% of patients. The arrhythmogenic effect of the drug was recorded in 12.5% of patients. The action of ethacizine when administered by both routes was accompanied by a significant elongation of the P--Q interval, QRS complex and of the cycle of ventricular tachycardia. Continuous administration of ethacizine in the daily dose 150 mg to patients with a positive antiarrhythmic drug action (according to the electrophysiological data) prevented paroxysms of ventricular tachycardia, with the observation period being 2 to 6.5 years.

[The diagnosis and possibilities for the anti-arrhythmia treatment of malignant ventricular disorders of the heart rhythm]. / Diagnostika i vozmozhnosti protivoaritmicheskogo lecheniia zlokachestvennykh zheludochkovykh narushenii ritma serdtsa.

Altogether 130 patients with malignant ventricular disorders of cardiac rhythm were examined to demonstrate a possibility of obtaining the diagnostically significant data with the aid of Holter's monitoring of the ECG in 89.2%, with the aid of bicycle ergometry exercise tests in 72.3%, and by means of an electrophysiological examination of the heart in 82.5% of the above-indicated group of patients. The drug testing with the use of invasive and noninvasive techniques of monitoring the action of antiarrhythmic drugs given per os makes it possible to choose effective therapy on an individual basis. The long-term use of such therapy may prevent ventricular tachycardia relapses and noticeably enhance the patients' survival. Severe organic pathology of the heart associated with a decrease of its pump function seen in the majority of patients with malignant ventricular disorders of cardiac rhythm refractory to pharmacotherapy restricts, in a considerable number of cases, the potentialities of drastic surgical treatment because of the risk of operative death. To improve the disease prognosis of these patients, it is necessary that other methods of nonmedicamentous treatment may be used, requiring a less scope of surgical intervention, such as implantation of a cardioverter-defibrillator.

[Effect of allapinin on the function of the atrioventricular conduction system of the heart]. / Vliianie allapinina na funktsiiu predserdno-zheludochkovoi Provodiashchei sistemy serdtsa.

The effect of allapinin on atrioventricular conductivity was assessed at intracardiac electrophysiologic investigation in 11 patients with various heart rhythm disorders. The effect of a 30 mg intravenous dose of the drug was evaluated 60 min after the injection. Allapinin significantly lengthened the P-Q interval and expanded the QRS complex. The effect was associated with a 24% increment in the P-A interval, a 7% increment in the A-H interval and a 31% increment in the H-V interval, suggesting that allapinin can be regarded as belonging to the first class of antiarrhythmic agents by Vaughan Williams' classification. Allapinin also shortened effective refractory time of the atrium and the atrioventricular node, as well as the total refractory period of the His-Purkinje system. Ventricular refractory periods were also shortened insignificantly. The drug is therefore assumed to have a vagolytic or, perhaps, sympathomimetic action.

[Programmed endocardiac stimulation of the right ventricle in patients with various forms of ventricular disorders of the heart rhythm: the results and their significance]. / Programmnaia éndokardial'naia stimuliatsiia pravogo zheludochka u bol'nykh s razlichnymi formami zheludochkovykh narushenii ritma serdtsa: rezul'taty i ikh znachenie.

An intracardiac electrophysiologic study of 73 patients, including those without ventricular arrhythmias, those with chronic ventricular ectopic activity of varying levels, and those with paroxysmal or nonparoxysmal ventricular tachycardia, has identified specific electrophysiologic phenomena that may be used as criteria for the diagnosis of paroxysmal ventricular tachycardias and assessment of the effect of anti-arrhythmic drugs at electrophysiologic testing.

[Long-term intracardiac electrophysiological research on patients with paroxysmal ventricular tachycardias: a prospective method for the choice and evaluation of the effectiveness of anti-arrhythmia treatment]. / Dlitel'noe vnutriserdechnoe élektrofiziologicheskoe issledovanie u bol'nykh s paroksizmal'nymi zheludochkovymi takhikardiiami: perspektivnyi metod vybora i otsenki éffektivnosti antiaritmicheskogo lecheniia.

Fifteen patients with paroxysmal ventricular tachycardia (PVT) were subjected to prolonged intracardiac electrophysiologic investigation (EPI) combined with tests of a variety of antiarrhythmic agents. One to 4 (2 +/- 0.3) agents were found to be capable of preventing ventricular tachycardia in response to endocardial stimulation in 93.3% of cases. Subsequent antiarrhythmic treatment by a drug thus selected prevented ventricular tachycardia paroxysms in all patients: there were no recurrent paroxysms in 10 (71.4%) patients, while tachycardiac attacks grew much less frequent, as compared to the pretreatment situation, and could be easily controlled by an additional dose of the drug in 4 (28.6%). Prolonged intracardiac EPI is a highly efficient method of individual assessment of drugs' antiarrhythmic effect that allows a timely and correct choice of treatment capable of reliable prevention of paroxysms.