RESUMO
Twenty-two children with bronchial asthma and positive skin tests to house-dust allergen were subjected to a bronchial provocation test with the allergen, and both bronchial reactions and serum complement hemolytic activity were measured at different intervals after the challenge. Changes in complement hemolytic activity did not correspond either with early or late bronchial reaction to the allergen. A reproducible drop in complement hemolytic activity after allergen challenge was observed in eight patients and could be prevented in four out of seven patients by sodium cromoglycate. The duration of early bronchial obstructive reaction was longer in tests where parallel complement changes were observed.
Assuntos
Alérgenos/administração & dosagem , Proteínas do Sistema Complemento/imunologia , Poeira/efeitos adversos , Hemólise , Adolescente , Alérgenos/imunologia , Asma/diagnóstico , Asma/imunologia , Testes de Provocação Brônquica , Espasmo Brônquico/tratamento farmacológico , Espasmo Brônquico/etiologia , Espasmo Brônquico/imunologia , Criança , Cromolina Sódica/administração & dosagem , Volume Expiratório Forçado , Hemólise/efeitos dos fármacos , HumanosRESUMO
Induction of the immunoglobulin production by pokeweed mitogen (PWM) and S. aureus. Cowan I has been evaluated in cultures of human peripheral blood mononuclear cells gradually depleted of adherent cells. Partial depletion cells (monitoglobulins while almost complete depletion caused decreased production. These results suggest that an optimal balance of monocytes to lymphocytes is essential in the triggering of immunoglobulin production by human mononuclear cells (MNC) in vitro and that normal monocytes, when in excess, suppress in vitro differentiation of B lymphocytes into immunoglobulin secreting cells.